Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Astrid Vallès"'
Autor:
Irena Bočkaj, Anna Moreno Garcia, Pablo de Miguel Herraiz, Sonay Keskin, Vanessa Zancanella, Şeyda Acar Broekmans, Astrid Vallès, Ying Poi Liu, Melvin Evers, Morgane Wartel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102307- (2024)
Given that numerous genetic disorders, driven by diverse pathogenic mechanisms, may be amenable to recombinant adeno-associated virus (rAAV)-delivered gene therapies, the sustained innovation of rAAV-based therapeutic modalities is crucial. The progr
Externí odkaz:
https://doaj.org/article/1a25866587ba456692cfabb12dd9d7ec
Autor:
Vanessa Zancanella, Astrid Vallès, Jolanda M.P. Liefhebber, Lieke Paerels, Carlos Vendrell Tornero, Hendrina Wattimury, Tom van der Zon, Kristel van Rooijen, Monika Golinska, Tamar Grevelink, Erich Ehlert, Elsbet Jantine Pieterman, Nanda Keijzer, Hans Marinus Gerardus Princen, Geurt Stokman, Ying Poi Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102189- (2024)
Externí odkaz:
https://doaj.org/article/6fce894ae2cc4820930f11537ace45e7
Autor:
Vanessa Zancanella, Astrid Vallès, Jolanda M.P. Liefhebber, Lieke Paerels, Carlos Vendrell Tornero, Hendrina Wattimury, Tom van der Zon, Kristel van Rooijen, Monika Golinska, Tamar Grevelink, Erich Ehlert, Elsbet Jantine Pieterman, Nanda Keijzer, Hans Marinus Gerardus Princen, Geurt Stokman, Ying Poi Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 454-467 (2023)
A gene-silencing platform (miQURE) has been developed and successfully used to deliver therapeutic microRNA (miRNA) to the brain, reducing levels of neurodegenerative disease-causing proteins/RNAs via RNA interference and improving the disease phenot
Externí odkaz:
https://doaj.org/article/0d8c24346e504114948232885b1d3acd
Autor:
Dorien A. Maas, Vivian D. Eijsink, Marcia Spoelder, Josephus A. van Hulten, Peter De Weerd, Judith R. Homberg, Astrid Vallès, Brahim Nait-Oumesmar, Gerard J. M. Martens
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Dysfunction of GABAergic neurons in the prefrontal cortex has been reported in schizophrenia. Here, the authors use the apomorphine-susceptible rat, which displays some schizophrenia-like behaviors, and show that interneurons in the medial prefrontal
Externí odkaz:
https://doaj.org/article/34c57aa0fb3a4c8899725ee021846a0b
Autor:
Sonay Keskin, Cynthia C. Brouwers, Marina Sogorb-Gonzalez, Raygene Martier, Josse A. Depla, Astrid Vallès, Sander J. van Deventer, Pavlina Konstantinova, Melvin M. Evers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 275-284 (2019)
Huntington disease (HD) is a fatal neurodegenerative genetic disorder, thought to reflect a toxic gain of function in huntingtin (Htt) protein. Adeno-associated viral vector serotype 5 (AAV5)- microRNA targeting huntingtin (miHTT) is a HD gene-therap
Externí odkaz:
https://doaj.org/article/ea22fa55f85944d198f8e622dca8256f
Autor:
Roberto D. V. S. Morais, Marina Sogorb-González, Citlali Bar, Nikki C. Timmer, M. Leontien Van der Bent, Morgane Wartel, Astrid Vallès
Publikováno v:
Cells, Vol 11, Iss 17, p 2748 (2022)
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by GAG expansion in exon 1 of the huntingtin (HTT) gene. AAV5-miHTT is an adeno-associated virus serotype 5-based vector expressing an engineered HTT-targeting microRNA (miHTT).
Externí odkaz:
https://doaj.org/article/34d98b50c74a4ed08dd0502971363f9c
Autor:
Elisabeth A. Spronck, Cynthia C. Brouwers, Astrid Vallès, Martin de Haan, Harald Petry, Sander J. van Deventer, Pavlina Konstantinova, Melvin M. Evers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 334-343 (2019)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by an autosomal dominant CAG repeat expansion in the huntingtin (HTT) gene. The translated expanded polyglutamine repeat in the HTT protein is known to cause toxic gain of function.
Externí odkaz:
https://doaj.org/article/80df46c476b84f378c89927542f2b137
Autor:
Elisabeth A. Spronck, Astrid Vallès, Margit H. Lampen, Paula S. Montenegro-Miranda, Sonay Keskin, Liesbeth Heijink, Melvin M. Evers, Harald Petry, Sander J. van Deventer, Pavlina Konstantinova, Martin de Haan
Publikováno v:
Brain Sciences, Vol 11, Iss 2, p 129 (2021)
Huntington disease (HD) is a fatal, neurodegenerative genetic disorder with aggregation of mutant Huntingtin protein (mutHTT) in the brain as a key pathological mechanism. There are currently no disease modifying therapies for HD; however, HTT-loweri
Externí odkaz:
https://doaj.org/article/003bb3f8cb854143be21f0cb86c10923
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 312-322 (2006)
Chemokine receptors represent promising targets to attenuate inflammatory responses and subsequent secondary damage after brain injury. We studied the response of the chemokines CXCL1/CINC-1 and CXCL2/MIP-2 and their receptors CXCR1 and CXCR2 after c
Externí odkaz:
https://doaj.org/article/812e66c36f93450088a7dafb28fcbb04
Publikováno v:
Biologics: Targets and Therapy. 16:141-160
Huntington's disease is a devastating heritable neurodegenerative disorder that is caused by the presence of a trinucleotide CAG repeat expansion in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0dcedf125a8a73b3e5775d9c6933c50
https://doi.org/10.2147/btt.s270657
https://doi.org/10.2147/btt.s270657