Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Astrid Skjesol"'
Autor:
Kaja Elisabeth Nilsen, Astrid Skjesol, June Frengen Kojen, Terje Espevik, Jørgen Stenvik, Maria Yurchenko
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1476 (2022)
Toll-like receptor 8 (TLR8) recognizes single-stranded RNA of viral and bacterial origin as well as mediates the secretion of pro-inflammatory cytokines and type I interferons by human monocytes and macrophages. TLR8, as other endosomal TLRs, utilize
Externí odkaz:
https://doaj.org/article/4f43e20661924dd2a97f7398601252b5
Autor:
Prashanna Guragain, Bjørnar Sporsheim, Astrid Skjesol, Anna Solvang Båtnes, Yngvar Olsen, Atle M. Bones, Per Winge
Publikováno v:
Frontiers in Marine Science, Vol 7 (2020)
Phenylalanine hydroxylase (PAH) is a crucial enzyme involved in tyrosine biosynthesis, having roles in neurological and physiological processes. The purpose of PAH has received little attention in crustaceans despite extensive investigations in other
Externí odkaz:
https://doaj.org/article/e36eff90d1154e83958373ed65403f91
Autor:
Astrid Skjesol, Mariia Yurchenko, Korbinian Bösl, Caroline Gravastrand, Kaja Elisabeth Nilsen, Lene Melsæther Grøvdal, Federica Agliano, Francesco Patane, Germana Lentini, Hera Kim, Giuseppe Teti, Aditya Kumar Sharma, Richard K Kandasamy, Bjørnar Sporsheim, Kristian K Starheim, Douglas T Golenbock, Harald Stenmark, Mary McCaffrey, Terje Espevik, Harald Husebye
Publikováno v:
PLoS Pathogens, Vol 15, Iss 3, p e1007684 (2019)
Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative bacteria. Moreover, TLR4 has bee
Externí odkaz:
https://doaj.org/article/0154430610c447ce88ec48ab14ae47bf
Autor:
Mehrdad Sobhkhez, Astrid Skjesol, Ernst Thomassen, Linn Greiner Tollersrud, Dimitar B. Iliev, Baojian Sun, Børre Robertsen, Jorunn B. Jørgensen
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 858-871 (2014)
Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to p
Externí odkaz:
https://doaj.org/article/20816fdb603a43a4a4303bb5d2be6e97
Autor:
Guy Cohen, Lene Melsæther Grøvdal, Terje Espevik, Arie Gruzman, Astrid Skjesol, Edward E. Korshin, Lena Trifonov, Harald Husebye, Mariya Yurchenko
Publikováno v:
Molecular diversity. 26(4)
IFN-β is a cytokine that plays a significant role in the immune system. Inhibition of IFN-β might be used as a therapeutic approach to treat septic shock. A peptidomimetic previously developed by our research team, 1-benzyl-5-methyl-4-(n-octylamino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0e8f536bc2b3fde2d081e94d65cb98
https://pubmed.ncbi.nlm.nih.gov/34668104
https://pubmed.ncbi.nlm.nih.gov/34668104
Autor:
Harald Husebye, Caroline Gravastrand, Astrid Skjesol, Mariia Yurchenko, Aleksandra Jakovljev, Jan Egil Afset, Terje Espevik
Publikováno v:
The Journal of Immunology. 204:68.26-68.26
Evidence that membrane trafficking and anchoring at the trans-Golgi network is important for NLRP3 inflammasome activation is now emerging. The Rab11-family interacting protein 2 (FIP2) is a key regulator of intracellular vesicle trafficking and has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e058e44fae7eaeab660d8976e70b5ad
https://doi.org/10.4049/jimmunol.204.supp.68.26
https://doi.org/10.4049/jimmunol.204.supp.68.26
Autor:
Ninghai Wang, Terje Espevik, Astrid Skjesol, Harald Husebye, Gabriel Mary Richard, Richard Kumaran Kandasamy, Mariya Yurchenko, Liv Ryan, Cox Terhorst
Publikováno v:
Journal of Cell Biology
The Journal of Cell Biology
The Journal of Cell Biology
Yurchenko et al. discover that the Ig-like receptor molecule SLAMF1 enhances production of type I interferon induced by Gram-negative bacteria through modulation of MyD88-independent TLR4 signaling. This makes SLAMF1 a potential target for controllin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b9675754f99c4309ff6dec8e898184
https://hdl.handle.net/11250/2487510
https://hdl.handle.net/11250/2487510
Autor:
Esther D. Kers-Rebel, Kjartan Egeberg, Astrid Skjesol, Harald Husebye, Bjørnar Sporsheim, Terje Espevik, Tatyana Sherstova, Dionne C.G. Klein, Bjørn T. Stokke
Publikováno v:
Traffic. 16:677-690
Toll-like receptor 4 (TLR4) is responsible for the immediate response to Gram-negative bacteria and signals via two main pathways by recruitment of distinct pairs of adaptor proteins. Mal-MyD88 [Mal (MyD88-adaptor-like) - MYD88 (Myeloid differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11c5c18c427c804d12a0ad0027a748f2
https://doi.org/10.1111/tra.12274
https://doi.org/10.1111/tra.12274
Autor:
Christopher J. Secombes, Mehrdad Sobhkhez, Dimitar B. Iliev, Astrid Skjesol, Linn Greiner Tollersrud, Theresa Liebe, Lisbeth Lindenskov Joensen, Jorunn B. Jørgensen, Ernst I.S. Thomassen
Publikováno v:
Developmental & Comparative Immunology. 45:177-189
Suppressor of cytokine signaling (SOCS) proteins are crucially involved in the control of inflammatory responses through their impact on various signaling pathways including the JAK/STAT pathway. Although all SOCS protein family members are identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac49f0c42bd68ca49d0041504b4188b2
https://doi.org/10.1016/j.dci.2014.02.009
https://doi.org/10.1016/j.dci.2014.02.009
Publikováno v:
Developmental & Comparative Immunology. 41:553-563
Tyk2, a member of the Janus Kinase (JAK) family of protein tyrosine kinases, is required for interferon-α/β binding and signaling in higher vertebrates. Currently, little is known about the role of the different JAKs in signaling responses to inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02388df750475c3bae5764d2103ec9a1
https://doi.org/10.1016/j.dci.2013.07.008
https://doi.org/10.1016/j.dci.2013.07.008