Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Astrid S. Clarke"'
Autor:
Kyle G. Williams, Ramya Kongala, Donna M. Shows, Andrew J. Konecny, Duncan C. Hindmarch, Astrid S. Clarke, James D. Lord
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 119-130 (2024)
Background & Aims: Inflammatory bowel disease (IBD) causes a marked increase in the number of T cells in the intestinal mucosa. Debate exists about whether these excess cells arise from local clonal proliferation or recruitment from the periphery. Me
Externí odkaz:
https://doaj.org/article/ee9454018c844a7b80fe3559c671e348
Autor:
Christopher W. Pohlmeyer, Ching Shang, Pei Han, Zhi-Hua Cui, Randall M. Jones, Astrid S. Clarke, Bernard P. Murray, David A. Lopez, David W. Newstrom, M. David Inzunza, Franziska G. Matzkies, Kevin S. Currie, Julie A. Di Paolo
Publikováno v:
BMC Rheumatology, Vol 5, Iss 1, Pp 1-13 (2021)
Abstract Background B cells are critical mediators of systemic lupus erythematosus (SLE) and lupus nephritis (LN), and antinuclear antibodies can be found in the serum of approximately 98% of patients with SLE. Spleen tyrosine kinase (SYK) is a nonre
Externí odkaz:
https://doaj.org/article/1045f0e3e1234e489fba36f11c62f5d1
Autor:
Emma Rousseau, Roy Bannister, Kevin S. Currie, Jiyun Kim, Astrid S. Clarke, Kelly Wang, Julie Di Paolo, Franziska Matzkies, Bernard P. Murray
Publikováno v:
Thrombosis Research. 170:109-118
Introduction Spleen tyrosine kinase (SYK) mediates signal transduction in multiple hematopoietic cells, including platelets. SYK signals downstream of immunoreceptors and SYK inhibition may ameliorate disease pathology in multiple autoimmune disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c447b0f31135a56402781f947c1baad9
https://doi.org/10.1016/j.thromres.2018.08.012
https://doi.org/10.1016/j.thromres.2018.08.012
Publikováno v:
Journal of Crohn's and Colitis. 14:S409-S409
Background Inhibitors of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway have demonstrated efficacy in the treatment of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Differences in selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae28d4d3b4a5b62b0d9d6cb0c21053c
https://doi.org/10.1093/ecco-jcc/jjz203.589
https://doi.org/10.1093/ecco-jcc/jjz203.589
Autor:
C. Pohlmeyer, Z.-H. Cui, J. A. Di Paolo, S. Zaboli, A. Shauf, Nevena Mollova, Randall Mark Jones, Igor Mikaelian, Pei Han, Astrid S. Clarke
Publikováno v:
Rheumatoid arthritis – non biologic treatment and small molecules.
Background Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterised by immune system hyperactivation leading to the production of autoantibodies and immune attack on multiple organs including the skin and kidneys. High l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::253eec6a960895ab0b586085829bb095
https://doi.org/10.1136/annrheumdis-2018-eular.3367
https://doi.org/10.1136/annrheumdis-2018-eular.3367
Autor:
Brian J. Druker, Kevin S. Currie, Patricia Maciejewski, Russell T. Burke, Brian J. Lannutti, Julie DiPaolo, Stephen E. Spurgeon, Marc M. Loriaux, Sarah A. Meadows, Scott A. Mitchell, Astrid S. Clarke
Publikováno v:
Oncotarget
Agents that target B-cell receptor (BCR) signaling in lymphoid malignancies including idelalisib (GS-1101) and fostamatinib which inhibit the delta isoform of PI3 kinase (PI3Kd) and spleen tyrosine kinase (Syk) respectively have shown significant cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586b96018817e74b23f80ce982b02789
http://europepmc.org/articles/PMC4011593
http://europepmc.org/articles/PMC4011593
Autor:
Kevin M. Marks, Henry E. Pelish, Jennifer E. Ring, Astrid S. Clarke, Katie Russo, Jon Clardy, Eun Sun Park, Alexander Arefolov, Keiko Ishihara
Publikováno v:
Journal of Natural Products
The natural product austocystin D was identified as a potent cytotoxic agent with in vivo antitumor activity and selectivity for cells expressing the multidrug resistance transporter MDR1. We sought to elucidate the mechanism of austocystin D's selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb861b81fa287dd71a8f7bed2c930c1f
https://doi.org/10.1021/np100429s
https://doi.org/10.1021/np100429s
Publikováno v:
Journal of Biological Chemistry. 270:22673-22676
The integrin alpha 6 beta 4, a receptor for members of the laminin family of basement membrane components, contributes to the function of epithelial cells and their oncogenically transformed derivatives. In our efforts to study alpha 6 beta 4-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ec5a75adbb08e33f5d32d4f8c60486
https://doi.org/10.1074/jbc.270.39.22673
https://doi.org/10.1074/jbc.270.39.22673
Publikováno v:
Cell Adhesion and Communication. 2:1-6
The ability of the alpha 6 beta 4 integrin to function as a laminin receptor appears to be cell-type dependent. We reported that this integrin functions as a laminin receptor on clone A cells, a colon carcinoma cell line (Lee et al., J. Cell Biol., 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5109ab486ff6edabbd5ae31633faecdb
https://doi.org/10.3109/15419069409014197
https://doi.org/10.3109/15419069409014197
Autor:
Charles W. Andrews, Astrid S. Clarke, Glenn Steele, Cynthia A. Korzelius, Margaret M. Lotz, Arthur M. Mercurio, Edward C. Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 90:3466-3470
The Mac-2 lectin (carbohydrate binding protein 35) is a soluble, 32- to 35-kDa phosphoprotein that binds galactose-containing glycoconjugates. We report here that the colonic epithelium is a major site of Mac-2 expression in vivo based on immunohisto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6347027a5eeb24d5bd3acfa3a81e55
https://doi.org/10.1073/pnas.90.8.3466
https://doi.org/10.1073/pnas.90.8.3466