Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Astrid S, Pfister"'
Autor:
Silke D. Werle, Nensi Ikonomi, Julian D. Schwab, Johann M. Kraus, Felix M. Weidner, K. Lenhard Rudolph, Astrid S. Pfister, Rainer Schuler, Michael Kühl, Hans A. Kestler
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1603-1617 (2022)
Controlling phenotypical landscapes is of vital interest to modern biology. This task becomes highly demanding because cellular decisions involve complex networks engaging in crosstalk interactions. Previous work on control theory indicates that smal
Externí odkaz:
https://doaj.org/article/d0b5b7f5c42942bfa222393dd1bb697b
Autor:
Astrid S. Pfister
Publikováno v:
Cells, Vol 12, Iss 16, p 2071 (2023)
Nucleolar stress reflects a misfunction of the nucleolus caused by a failure in ribosome biogenesis and defective nucleolar architecture. Various causes have been reported, most commonly mutation of ribosomal proteins and ribosome processing factors,
Externí odkaz:
https://doaj.org/article/c5c27dc26c66419c9beb38636add22c1
Autor:
Astrid S. Pfister
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Autophagy represents a conserved self-digestion program, which allows regulated degradation of cellular material. Autophagy is activated by cellular stress, serum starvation and nutrient deprivation. Several autophagic pathways have been uncovered, w
Externí odkaz:
https://doaj.org/article/1b4eddce6163493d82740e25975ab213
Autor:
Lea Siegle, Julian D Schwab, Silke D Kühlwein, Ludwig Lausser, Stefan Tümpel, Astrid S Pfister, Michael Kühl, Hans A Kestler
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0195126 (2018)
Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosst
Externí odkaz:
https://doaj.org/article/3234458c01a54063be25c6075322103f
Publikováno v:
J Biol Chem
Proper ribosome formation is a prerequisite for cell growth and proliferation. Failure of this process results in nucleolar stress and p53-mediated apoptosis. The Wnt target Peter Pan (PPAN) is required for 45 S rRNA maturation. So far, the role of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60152304d725be3ccad1a62af1754c0b
https://europepmc.org/articles/PMC9803914/
https://europepmc.org/articles/PMC9803914/
Autor:
David P. Dannheisig, Eileen Beck, Enrico Calzia, Paul Walther, Christian Behrends, Astrid S. Pfister
Publikováno v:
Cells, Vol 8, Iss 8, p 894 (2019)
Nucleolar stress is a cellular response to inhibition of ribosome biogenesis or nucleolar disruption leading to cell cycle arrest and/or apoptosis. Emerging evidence points to a tight connection between nucleolar stress and autophagy as a mechanism u
Externí odkaz:
https://doaj.org/article/3d681e057d5b4ee19a8475cacddfd20b
Publikováno v:
Cancers
Cancers; Volume 13; Issue 24; Pages: 6220
Cancers, Vol 13, Iss 6220, p 6220 (2021)
Cancers; Volume 13; Issue 24; Pages: 6220
Cancers, Vol 13, Iss 6220, p 6220 (2021)
Simple Summary Ribosome biogenesis takes place in nucleoli and is essential for cellular survival and proliferation. In case this function is disturbed, either due to defects in regulatory factors or the structure of the nucleolus, nucleolar stress i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdad36b6b6edc5ccf85d75ceaaac621b
http://europepmc.org/articles/PMC8699128
http://europepmc.org/articles/PMC8699128
Autor:
David P. Dannheisig, Astrid S. Pfister, Maria T. Meyer, Melanie Philipp, Lars D. Maerz, Marina Keil
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:882-895
The nucleolus is a subnuclear compartment, which governs ribosome biogenesis. Moreover, it functions as hub in the stress response by orchestrating a variety of processes, such as regulation of cell cycle progression, senescence and apoptosis. Emergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11989f75e8d8420dc4888de5020b7b6b
https://doi.org/10.1016/j.bbamcr.2019.01.010
https://doi.org/10.1016/j.bbamcr.2019.01.010
Autor:
Oliver Pötz, Michael Kühl, Silke D. Kühlwein, Barbara Kracher, Luc De Raedt, Hans A. Kestler, Astrid S. Pfister, Alexander Groß, Thomas O. Joos, Sebastian Wiese, Dries Van Daele, Katrin Luckert, Johann M. Kraus
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-12 (2019)
Communications Biology
Communications Biology
Dynamic models analyzing gene regulation and metabolism face challenges when adapted to modeling signal transduction networks. During signal transduction, molecular reactions and mechanisms occur in different spatial and temporal frames and involve f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4276b506695891650cb756fb7ce77550
http://link.springer.com/article/10.1038/s42003-018-0268-3
http://link.springer.com/article/10.1038/s42003-018-0268-3
Autor:
Yanchun Guo, Susanne J Kühl, Astrid S Pfister, Wiebke Cizelsky, Stephanie Denk, Laura Beer-Molz, Michael Kühl
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87294 (2014)
The family of vertebrate Mef2 transcription factors is comprised of four members named Mef2a, Mef2b, Mef2c, and Mef2d. These transcription factors are regulators of the myogenic programs with crucial roles in development of skeletal, cardiac and smoo
Externí odkaz:
https://doaj.org/article/8b0e5118790247a9884a67e2b2824ba1