Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Astrid Pornon"'
Autor:
Simon Wöhrle, Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami, Zainab Jagani, Anne Thuery, Beatrice Bauer-Probst, Flavia Reimann, Christelle Stamm, Astrid Pornon, Vincent Romanet, Vito Guagnano, Thomas Brümmendorf, William R Sellers, Francesco Hofmann, Charles W M Roberts, Diana Graus Porta
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77652 (2013)
Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1. MRTs are poorly responsive to chemotherapy and thus a high unmet clinic
Externí odkaz:
https://doaj.org/article/5ddabf7e37d840fe9ce647ad449900b5
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
PDF file - 1.4MB, Response to NVP-BGJ398; FGFR pathway modulation by NVP-BGJ398; NVP-BGJ398 - predictive features; FGFR2-c3 mRNA expression in cell lines and FGFR2 DNA copy number in tumors; FGF19 DNA copy number in CCLE cell lines and FGFR3 DNA copy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055d71ccbe50a65e308a5319a0af558a
https://doi.org/10.1158/2159-8290.22529469
https://doi.org/10.1158/2159-8290.22529469
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
XML file - 99K, Kinase activity and selectivity for NVP-BGJ398; CCLE cell lines sensitive to NVP-BGJ398; GeneSet expression signatures; FGFR genetic alterations and concomitant mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394b8c19ed3865b26c4b23f7077d34aa
https://doi.org/10.1158/2159-8290.22529463.v1
https://doi.org/10.1158/2159-8290.22529463.v1
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
XML file - 56K, High throughput pharmacological screen of BGJ398 in 517 cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2881a9c58817a03993b13427e5d262a1
https://doi.org/10.1158/2159-8290.22529466.v1
https://doi.org/10.1158/2159-8290.22529466.v1
Autor:
Kavitha Venkatesan, Vincent Bordas, Moriko Ito, Yun Zhang, David Thomas, Vito Guagnano, Zhi Chen, Louise Barys, Christelle Stamm, Astrid Pornon, Simon Wöhrle, William R. Sellers, Audrey Kauffmann, Christine D. Wilson, Yao Yao, Thomas Brümmendorf, Francesco Hofmann, L. Alex Gaither, Fang Li, Mickaël Le Douget, John Monahan, Diana Graus-Porta, Jason Borawski, Carlos Garcia-Echeverria
Publikováno v:
Cancer Discovery. 2:1118-1133
Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36ca42da44e334c8fce42a8c299c8af
https://doi.org/10.1158/2159-8290.cd-12-0210
https://doi.org/10.1158/2159-8290.cd-12-0210
Autor:
Emiko Kawachi, Koichi Shudo, Astrid Pornon, Pierre Chambon, Ghislaine Eisenmann, Hiroki Umemiya, Hinrich Gronemeyer, Masayuki Ebisawa, Yuichi Hashimoto, Hiroshi Fukasawa, Cathie Erb, Hiroyuki Kagechika
Publikováno v:
Biochemical and Biophysical Research Communications. 233:121-125
4-[5H-2,3-(2,5-Dimethyl-2,5-hexano)-5-methyldibenzo[b,e][1,4 ]diazepin-11-yl]benzoic acid (HX600), as well as its oxa- (HX620) and thia- (HX630) analogs, enhanced the activity of retinoic acid and a receptor alpha (RAR alpha)-selective agonist Am80 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b0ca9940036e2f35373ee6ef2bc39f
https://doi.org/10.1006/bbrc.1997.6414
https://doi.org/10.1006/bbrc.1997.6414
Publikováno v:
The EMBO Journal. 9:3923-3932
RU486 induced the binding to a palindromic progestin responsive element (PRE) in vitro of homo- and heterodimers of the human progesterone receptor (hPR) isoforms A and B, present in T47D breast cancer cells or in HeLa cells transiently expressing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7395d3825f5776043dd82e0e6e1b1fb
https://doi.org/10.1002/j.1460-2075.1990.tb07613.x
https://doi.org/10.1002/j.1460-2075.1990.tb07613.x
Autor:
Masato Murakami, Sébastien Jeay, Daniel Guthy, Stephane Ferretti, Louise Barys, Geneviève Albrecht, Stephan Ruetz, Astrid Pornon, Kavitha Venkatesan, Jianjun Yu, Jens Wuerthner, Ensar Halilovic, Diana Graus-Porta, Swann Gaulis, Michael Rugaard Jensen, Marion Wiesmann, Moriko Ito
Publikováno v:
Cancer Research. 74:2909-2909
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Patient selection biomarkers are essential for the successful and rapid development of emerging targeted anti-cancer therapeutics. In this study we have identified a novel patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8487110dc69783e124c792b06210e26
https://doi.org/10.1158/1538-7445.am2014-2909
https://doi.org/10.1158/1538-7445.am2014-2909
Autor:
Charles W. M. Roberts, Flavia Reimann, Simon Wöhrle, Audrey Kauffmann, Thomas Brümmendorf, Masato Murakami, Vito Guagnano, Andreas Weiss, Zainab Jagani, Astrid Pornon, Beatrice Bauer-Probst, Vincent Romanet, Christelle Stamm, Moriko Ito, William R. Sellers, Francesco Hofmann, Diana Graus Porta, Anne Thuery
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e77652 (2013)
PLoS ONE, Vol 8, Iss 10, p e77652 (2013)
Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1. MRTs are poorly responsive to chemotherapy and thus a high unmet clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709652f4af067c6b5632a2a9e96a3944
https://doi.org/10.1371/journal.pone.0077652
https://doi.org/10.1371/journal.pone.0077652
Publikováno v:
Breast Cancer Research : BCR
Introduction Endocrine-dependent, estrogen receptor positive breast cancer cells proliferate in response to estrogens, synthesized by the cytochrome p450 aromatase enzyme. Letrozole is a potent nonsteroidal aromatase inhibitor that is registered for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311664a1e26e68777f3de056df4d7a38