Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Astrid Osen-Sand"'
Autor:
Francis Vilbois, Alena Hochmann, Jean-Claude Martinou, Bruno Antonsson, Solange Desagher, Sylvie Montessuit, Astrid Osen-Sand, Laurent Journot, Edith Magnenat
Publikováno v:
Molecular Cell. 8(3):601-611
Bid plays an essential role in Fas-mediated apoptosis of the so-called type II cells. In these cells, following cleavage by caspase 8, the C-terminal fragment of Bid translocates to mitochondria and triggers the release of apoptogenic factors, thereb
Autor:
Jean-Claude Martinou, Sandra Lauper, Sylvie Montessuit, Robert Eskes, Bruno Antonsson, Kinsey Maundrell, Anthony Nichols, Astrid Osen-Sand, Solange Desagher
Publikováno v:
The Journal of Cell Biology
Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cytosol to mitochondria. This event is associated with a change in conformation of Bax which leads to the unmasking of i
Autor:
Christoph Richter, Gonzalo Mazzei, Sylvie Montessuit, Astrid Osen-Sand, Rémy Sadoul, Jean-Claude Martinou, Bruno Antonsson, Anthony Nichols, Robert Eskes
Publikováno v:
The Journal of Cell Biology
Bcl-2 family members either promote or repress programmed cell death. Bax, a death-promoting member, is a pore-forming, mitochondria-associated protein whose mechanism of action is still unknown. During apoptosis, cytochrome C is released from the mi
Autor:
Marina Catsicas, Gabriele Grenningloh, Stefan Catsicas, Guidon Ayala, Astrid Osen-Sand, Kenneth Jones, Jonathan Knowles, Julie K. Staple
Publikováno v:
Nature. 364:445-448
Axonal elongation and the transformation of growth cones to synaptic terminals are major steps of brain development and the molecular mechanisms involved form the basis of the correct wiring of the nervous system. The same mechanisms may also contrib
Publikováno v:
The European journal of neuroscience. 9(4)
We have quantified activity-dependent uptake of the fluorescent dye FM1-43 in combination with immunocytochemistry for synaptic vesicle-associated proteins (SVPs) at individual synapses in primary cultures of rat cortical neurons. We show that expres
Autor:
Ezio Naldi, Sylvie Petitpierre, Antonio Malgaroli, Stefan Catsicas, Giampietro Schiavo, Julie Staple, Cesare Montecucco, Astrid Osen-Sand, Ornella Rossetto
Publikováno v:
The Journal of comparative neurology. 367(2)
We have used the proteolytic properties of botulinum and tetanus neurotoxins (BoNT, TeNT) to cleave three proteins of the membrane fusion machinery, SNAP-25, VAMP/synaptobrevin, and syntaxin, in developing and differentiated rat central neurons in vi