Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Astrid Markus"'
Autor:
Reinhard Pabst, Christine Lehmann, Norbert Krug, Astrid Markus, Anja Wilkening, Daniela Leiber, Thomas Tschernig
Publikováno v:
The Anatomical Record. 264:229-236
Lymphocytes in the bronchoalveolar space are routinely obtained and examined in lung diseases such as asthma or sarcoidosis. In a pig model, labeled lymphocytes were found in regional lymph nodes after intrabronchial instillation, indicating that ree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbd3374a40d731282c22f9752f868ab
https://doi.org/10.1002/ar.1163
https://doi.org/10.1002/ar.1163
Autor:
Udo Kragl, Gerhard Range, Ralf Krähmer, Dietrich Müller, Guido F. Herrmann, Christian Wandrey, Astrid Markus, Jean van Heijenoort, Yveline van Heijenoort, Peter Welzel
Publikováno v:
Tetrahedron. 53:1695-1706
The trisaccharide moenomycin analogue 1c has been synthesized. One starting material was N-acetyllactosamine obtained by an enzyme-catalyzed transglycosylation. 1c differs from moenomycin degradation product 1a only in two positions of unit C. In con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0813cfa9c0f24ed0c344f24d3152dcc2
https://doi.org/10.1016/s0040-4020(96)01116-7
https://doi.org/10.1016/s0040-4020(96)01116-7
Autor:
Lothar Hennig, Matthias Findeisen, Dietrich Müller, Olaf Ritzeler, Guy Lemoine, Jean van Heijenoort, Astrid Markus, Maxime Lampilas, Peter Welzel
Publikováno v:
Tetrahedron. 53:1675-1694
A trisaccharide analogue of moenomycin A, 9a, has been synthesized and has found to be antibiotically inactive. This compound differs from an active compound, 9b, solely by the exchange NHAc→OH in unit C. A binding model for moenomycin-type transgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bc6156984a9fa7ebfcde525b3cf4ab9
https://doi.org/10.1016/s0040-4020(96)01115-5
https://doi.org/10.1016/s0040-4020(96)01115-5
Autor:
Dietrich Müller, Lothar Hennig, Astrid Markus, Matthias Findesien, Jean van Heijenoort, Ralf Kosmol, Peter Welzel
Publikováno v:
Journal für Praktische Chemie/Chemiker-Zeitung. 339:340-358
The transglycosylation step in the peptidoglycan biosynthesis belongs to the general class of glycosyltransferase-catalyzed reactions. The structural analogue 2 of moenomycin A has been synthesized and has been found to be antibiotically inactive. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccd50e05858df81b120599467eae6e66
https://doi.org/10.1002/prac.19973390162
https://doi.org/10.1002/prac.19973390162
Publikováno v:
Tetrahedron Letters. 37:5087-5090
A selective reaction at unit A of the antibiotic moenomycin A ( 1 ) has been developed: Reaction of 1 with o -nitrobenzenediazonium chloride cleanly yielded 12 . This compound is as active as moenomycin against Staph. aureus SG 511 and as an in-vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07f588eb0d5376df29273490c3eff3f9
https://doi.org/10.1016/0040-4039(96)01035-0
https://doi.org/10.1016/0040-4039(96)01035-0
Autor:
Lothar Hennig, Uwe Kempin, Yveline van Heijenoort, Hans-Wolfram Fehlhaber, Astrid Markus, Susanne Marzian, Peter Welzel, Jean van Heijenoort, Dietrich Müller
Publikováno v:
Tetrahedron. 51:8471-8482
On reaction with singlet oxygen 1 provided a mixture of 2 and 3 which could not be separated. In-vivo , 2/3 were antibiotically of low activity whereas in the in-vitro assays at least one of the compounds inhibited the transglycosylase effectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a8108f46b67884016b0af772bd549ae
https://doi.org/10.1016/0040-4020(95)00462-h
https://doi.org/10.1016/0040-4020(95)00462-h
Autor:
Astrid Markus, Dietrich Müller, Michael Limbert, Jean van Heijenoort, Yveline van Heijenoort, Hans-Jürgen Schütz, Markus Happel, Hans-Wolfram Fehlhaber, Andreas Stark, Ulrich Wagner, Susanne Marzian, Peter Welzel
Publikováno v:
Tetrahedron. 50:5299-5308
Methods for the removal and the oxidation of the lipid moiety of the antibiotic moenomycin A have been studied. Combined with biochemical studies, the results demonstrate that antibiotic activity is closely related with the integrity of the lipid uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5088bde22f9f563742949d74d145c7bc
https://doi.org/10.1016/s0040-4020(01)80688-8
https://doi.org/10.1016/s0040-4020(01)80688-8
Publikováno v:
Tetrahedron Letters. 35:1859-1862
The correct configuration at C-1 of the uronamide carrying the phosphate group is essential for antibiotic activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d64e7becf56790c6a06fb630d165891e
https://doi.org/10.1016/s0040-4039(00)73180-7
https://doi.org/10.1016/s0040-4039(00)73180-7
Autor:
Yveline van Heijenoort, Frauke Heinemann, Karsten Hohgardt, Harald Kühne, Wolfgang Dietrich, Detlef Grzelak, Monika Heuer, Jean van Heijenoort, Dietrich Müller, Peter Welzel, Astrid Markus
Publikováno v:
Tetrahedron. 50:2029-2046
Disaccharide derivative 1a is the smallest transglycosylase inhibiting compound known up to now. Structurally closely related compounds 11b and 19c have been synthesized. They do not inhibit the transglycosylase demonstrating the high specificity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5834d08677bab346b27900094b7d427
https://doi.org/10.1016/s0040-4020(01)85066-3
https://doi.org/10.1016/s0040-4020(01)85066-3
Autor:
Martina Heßler-Klintz, Astrid Markus, Gerhard Huber, Hans-Wolfram Fehlhaber, Dietrich Müller, Torsten Siegels, Andreas Stärk, Dirk Böttger, Armin Maulshagen, Gerhard Seibert, Jean van Heijenoort, Yveline van Heijenoort, Armin Biallaß, Kurt Hobert, Peter Welzel, Monika Hiegemann
Publikováno v:
Tetrahedron. 49:7667-7678
Isolation and structure elucidation of a new moenomycin antibiotic (C1, 1e) that lacks the branching methyl group in the 4-position of unit F are reported. The smallest antibiotically active degradation product of 1e is the trisaccharide derivative 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b95e6bbe28e5604f0621fbb2fe33dc61
https://doi.org/10.1016/s0040-4020(01)87242-2
https://doi.org/10.1016/s0040-4020(01)87242-2