Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease

Autor: Maroeska J. Burggraaf, Alexander Speer, Aniek S. Meijers, Roy Ummels, Astrid M. van der Sar, Konstantin V. Korotkov, Wilbert Bitter, Coenraad Kuijl

Publikováno v: mBio, Vol 10, Iss 5 (2019)

ABSTRACT Tuberculosis, one of the world’s most severe infectious diseases, is caused by Mycobacterium tuberculosis. A major weapon of this pathogen is a unique cell wall that protects the pathogen from eradication by the immune system. Mycobacteria

Externí odkaz: https://doaj.org/article/471da19eeb16404ebd6a78080b66c8b0

Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum

Autor: Lisanne M. van Leeuwen, Martijn van der Kuip, Sameh A. Youssef, Alain de Bruin, Wilbert Bitter, A. Marceline van Furth, Astrid M. van der Sar

Publikováno v: Disease Models & Mechanisms, Vol 7, Iss 9, Pp 1111-1122 (2014)

Tuberculous meningitis (TBM) is one of the most severe extrapulmonary manifestations of tuberculosis, with a high morbidity and mortality. Characteristic pathological features of TBM are Rich foci, i.e. brain- and spinal-cord-specific granulomas form

Externí odkaz: https://doaj.org/article/4c464ff8eb54415287da2bfa6f3a49b1

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF.

Autor: Trang H Phan, Lisanne M van Leeuwen, Coen Kuijl, Roy Ummels, Gunny van Stempvoort, Alba Rubio-Canalejas, Sander R Piersma, Connie R Jiménez, Astrid M van der Sar, Edith N G Houben, Wilbert Bitter

Publikováno v: PLoS Pathogens, Vol 14, Iss 8, p e1007247 (2018)

The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of ESX-1 secretion in virulence is well established, the characterization of its individual c

Externí odkaz: https://doaj.org/article/168aa6b95d0e4e7c9b73b8e47bd923a8

Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2

Autor: Anna Köhler, Nathalie Bravenboer, Raimund Wagener, Fleur S van Dijk, Brian T. Wilson, Juan A. Jimenez-Estrada, Markus Plomann, Dimitra Micha, Oliver Semler, Hanne Meijers-Heijboer, Mirko Rehberg, Carmen-Lisset Flores, Connie R. Jimenez, Gijs W. E. Santen, Elise Riesebos, Julian Nüchel, Alessandra Maugeri, Gerard Pals, A.A. Franken, Christian Netzer, Frank Zaucke, Lauria Claeys, Karen E. Heath, Heike Hoyer-Kuhn, Pablo Lapunzina, Matthias Mörgelin, Arjan G. J. Harsevoort, Astrid M. van der Sar, Julia Etich, Guus J. M. Janus, Quinten Waisfisz, Elisabeth M.W. Eekhoff, Simon Newstead, Peter G. J. Nikkels, Sander R. Piersma, Sejla Gegic, Victor L. Ruiz-Perez, Julián Nevado

Publikováno v: Am J Hum Genet
American journal of human genetics, 107(5), 989-999. Cell Press
American Journal of Human Genetics, 107(5), 989-999. CELL PRESS
van Dijk, F S, Semler, O, Etich, J, Köhler, A, Jimenez-Estrada, J A, Bravenboer, N, Claeys, L, Riesebos, E, Gegic, S, Piersma, S R, Jimenez, C R, Waisfisz, Q, Flores, C L, Nevado, J, Harsevoort, A J, Janus, G J M, Franken, A A M, van der Sar, A M, Meijers-Heijboer, H, Heath, K E, Lapunzina, P, Nikkels, P G J, Santen, G W E, Nüchel, J, Plomann, M, Wagener, R, Rehberg, M, Hoyer-Kuhn, H, Eekhoff, E M W, Pals, G, Mörgelin, M, Newstead, S, Wilson, B T, Ruiz-Perez, V L, Maugeri, A, Netzer, C, Zaucke, F & Micha, D 2020, ' Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2 ', American journal of human genetics, vol. 107, no. 5, pp. 989-999 . https://doi.org/10.1016/j.ajhg.2020.09.009
Digital.CSIC. Repositorio Institucional del CSIC
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Osteogenesis imperfecta (OI) is characterized primarily by susceptibility to fractures with or without bone deformation. OI is genetically heterogeneous: over 20 genetic causes are recognized. We identified bi-allelic pathogenic KDELR2 variants as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6e6f1f61c5a47a336d12359b7d5366
https://hdl.handle.net/1887/3185060

Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development

Autor: Piet H. van der Graaf, Theo Verboom, Ulrika S. H. Simonsson, Rob C. van Wijk, Herman P. Spaink, Astrid M. van der Sar, Elke H. J. Krekels

Publikováno v: Clinical and Translational Science
Clinical and translational Science
Van Wijk, R C, van der Sar, A M, Krekels, E H J, Verboom, T, Spaink, H P, Simonsson, U S H & van der Graaf, P H 2020, ' Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development ', Clinical and Translational Science, vol. 13, no. 6, pp. 1060-1064 . https://doi.org/10.1111/cts.12793
Clinical and Translational Science, 13(6), 1060-1064. Wiley-Blackwell
Clinical and translational Science, 13(6), 1060-1064

The zebrafish infected with Mycobacterium marinum is an attractive tuberculosis disease model, showing similar pathogenesis to Mycobacterium tuberculosis infections in humans. To translate pharmacological findings from this disease model to higher ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecafcbb00b1f16344a0707e184bc488
https://pubmed.ncbi.nlm.nih.gov/32267997