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Autor:
Roel Broekhuizen, Robert van Domselaar, Astrid M. van der Made, Niels Bovenschen, Razi Quadir
Publikováno v:
Journal of Biological Chemistry. 287:22854-22864
Granule exocytosis by cytotoxic lymphocytes is the key mechanism to eliminate virus-infected cells and tumor cells. These lytic granules contain the pore-forming protein perforin and a set of five serine proteases called granzymes. All human granzyme