Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Astrid M Westendorf"'
Autor:
Philine Steinbach, Eva Pastille, Lara Kaumanns, Alexandra Adamczyk, Kathrin Sutter, Wiebke Hansen, Ulf Dittmer, Jan Buer, Astrid M Westendorf, Torben Knuschke
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011982 (2024)
Influenza A virus (IAV) can cause severe respiratory infection leading to significant global morbidity and mortality through seasonal epidemics. Likewise, the constantly increasing number of cancer diseases is a growing problem. Nevertheless, the und
Externí odkaz:
https://doaj.org/article/a63e2a8e22f64398969f9161ce87c646
Autor:
Hanna Abberger, Matthias Hose, Anne Ninnemann, Christopher Menne, Mareike Eilbrecht, Karl S Lang, Kai Matuschewski, Robert Geffers, Josephine Herz, Jan Buer, Astrid M Westendorf, Wiebke Hansen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011837 (2023)
Neuropilin-1 (Nrp-1) expression on CD8+ T cells has been identified in tumor-infiltrating lymphocytes and in persistent murine gamma-herpes virus infections, where it interferes with the development of long-lived memory T cell responses. In parasitic
Externí odkaz:
https://doaj.org/article/7b59caa70b0d472fb4113dc9f186b875
Autor:
Matthias Hose, Anne Günther, Eyad Naser, Fabian Schumacher, Tina Schönberger, Julia Falkenstein, Athanasios Papadamakis, Burkhard Kleuser, Katrin Anne Becker, Erich Gulbins, Adriana Haimovitz-Friedman, Jan Buer, Astrid M Westendorf, Wiebke Hansen
Publikováno v:
eLife, Vol 11 (2022)
Acid sphingomyelinase (Asm) and acid ceramidase (Ac) are parts of the sphingolipid metabolism. Asm hydrolyzes sphingomyelin to ceramide, which is further metabolized to sphingosine by Ac. Ceramide generates ceramide-enriched platforms that are involv
Externí odkaz:
https://doaj.org/article/e8451a73e0d644448fa86305cbe73999
Autor:
Anne Günther, Matthias Hose, Hanna Abberger, Fabian Schumacher, Ylva Veith, Burkhard Kleuser, Kai Matuschewski, Karl Sebastian Lang, Erich Gulbins, Jan Buer, Astrid M Westendorf, Wiebke Hansen
Publikováno v:
eLife, Vol 11 (2022)
Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However, the impact of cell-intrinsic Ac activity a
Externí odkaz:
https://doaj.org/article/d7bfdd0ec15f450d8112fb8ebc0a7fda
Autor:
Alexandra Bick, Willem Buys, Andrea Engler, Rabea Madel, Mazen Atia, Francesca Faro, Astrid M Westendorf, Andreas Limmer, Jan Buer, Frank Herbstreit, Carsten J Kirschning, Jürgen Peters
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273247 (2022)
RationaleThe immune profile of sepsis patients is incompletely understood and hyperinflammation and hypoinflammation may occur concurrently or sequentially. Immune checkpoint inhibition (ICI) may counter hypoinflammation but effects are uncertain. We
Externí odkaz:
https://doaj.org/article/6ea8ff6976ca474f997f552712c7e3fe
Autor:
Paul David, Malgorzata Drabczyk-Pluta, Eva Pastille, Torben Knuschke, Tanja Werner, Nadine Honke, Dominik A Megger, Ilseyar Akhmetzyanova, Namir Shaabani, Annette Eyking-Singer, Elke Cario, Olivia Kershaw, Achim D Gruber, Matthias Tenbusch, Kirsten K Dietze, Mirko Trilling, Jia Liu, Dirk Schadendorf, Hendrik Streeck, Karl S Lang, Youhua Xie, Lisa Zimmer, Barbara Sitek, Annette Paschen, Astrid M Westendorf, Ulf Dittmer, Gennadiy Zelinskyy
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008340 (2020)
Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections. Whether such therapies are efficient during an acute infection remains elusive. To address this
Externí odkaz:
https://doaj.org/article/9987cb67515b4dc9a412c66b03e91f68
Autor:
Eva Pastille, Annika Frede, Henry J McSorley, Jessica Gräb, Alexandra Adamczyk, Sebastian Kollenda, Wiebke Hansen, Matthias Epple, Jan Buer, Rick M Maizels, Robert Klopfleisch, Astrid M Westendorf
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006649 (2017)
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the
Externí odkaz:
https://doaj.org/article/225dddf934d74fae8173e6fbd0eeb670
Autor:
Mohammadkarim Saeedghalati, Farnoush Farahpour, Bettina Budeus, Anja Lange, Astrid M Westendorf, Marc Seifert, Ralf Küppers, Daniel Hoffmann
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005362 (2017)
The community, the assemblage of organisms co-existing in a given space and time, has the potential to become one of the unifying concepts of biology, especially with the advent of high-throughput sequencing experiments that reveal genetic diversity
Externí odkaz:
https://doaj.org/article/42bc802e27bd4c3f9f0543865469732c
Autor:
Bärbel Stecher, Riccardo Robbiani, Alan W Walker, Astrid M Westendorf, Manja Barthel, Marcus Kremer, Samuel Chaffron, Andrew J Macpherson, Jan Buer, Julian Parkhill, Gordon Dougan, Christian von Mering, Wolf-Dietrich Hardt
Publikováno v:
PLoS Biology, Vol 5, Iss 10, Pp 2177-2189 (2007)
Most mucosal surfaces of the mammalian body are colonized by microbial communities ("microbiota"). A high density of commensal microbiota inhabits the intestine and shields from infection ("colonization resistance"). The virulence strategies allowing
Externí odkaz:
https://doaj.org/article/afeccb6446b84bc3975aa7e3de0727f6
Autor:
Simon T Schäfer, Sophia Gessner, André Scherag, Katharina Rump, Ulrich H Frey, Winfried Siffert, Astrid M Westendorf, Jörg Steinmann, Jürgen Peters, Michael Adamzik
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104953 (2014)
BACKGROUND:Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/del
Externí odkaz:
https://doaj.org/article/7eab1cf054f94afc931c248e79a86408