Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Astrid M Roy-Engel"'
Autor:
Maria E Morales, Rebecca S Derbes, Catherine M Ade, Jonathan C Ortego, Jeremy Stark, Prescott L Deininger, Astrid M Roy-Engel
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151367 (2016)
Heavy metals such as cadmium, arsenic and nickel are classified as carcinogens. Although the precise mechanism of carcinogenesis is undefined, heavy metal exposure can contribute to genetic damage by inducing double strand breaks (DSBs) as well as in
Externí odkaz:
https://doaj.org/article/ce64774b590a4e46a73be50b323b154d
Autor:
Bradley J Wagstaff, Dale J Hedges, Rebecca S Derbes, Rebeca Campos Sanchez, Francesca Chiaromonte, Kateryna D Makova, Astrid M Roy-Engel
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002842 (2012)
Alu elements are trans-mobilized by the autonomous non-LTR retroelement, LINE-1 (L1). Alu-induced insertion mutagenesis contributes to about 0.1% human genetic disease and is responsible for the majority of the documented instances of human retroelem
Externí odkaz:
https://doaj.org/article/a3d6b4d5493242569bc41f608ba1e3b4
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19672 (2011)
LINE-1 (L1) retroelements emerged in mammalian genomes over 80 million years ago with a few dominant subfamilies amplifying over discrete time periods that led to distinct human and mouse L1 lineages. We evaluated the functional conservation of L1 se
Externí odkaz:
https://doaj.org/article/d4d972c4b0264f20b648c75f48379255
Publikováno v:
PLoS Genetics, Vol 5, Iss 4, p e1000458 (2009)
Mobile elements comprise close to one half of the mass of the human genome. Only LINE-1 (L1), an autonomous non-Long Terminal Repeat (LTR) retrotransposon, and its non-autonomous partners-such as the retropseudogenes, SVA, and the SINE, Alu-are curre
Externí odkaz:
https://doaj.org/article/ebaa5206f44746c68692e3529a2c6137
Autor:
B. T. Freeman, Mark Sokolowski, Victoria P. Belancio, Madison E. Smither, Astrid M. Roy-Engel
Publikováno v:
Mobile DNA, Vol 10, Iss 1, Pp 1-17 (2019)
Mobile DNA
Mobile DNA
Background Long Interspersed Element 1 (LINE-1) is a retrotransposon that is present in 500,000 copies in the human genome. Along with Alu and SVA elements, these three retrotransposons account for more than a third of the human genome sequence. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9fd7333b0f2245abe8f91ce5463085
http://link.springer.com/article/10.1186/s13100-019-0159-2
http://link.springer.com/article/10.1186/s13100-019-0159-2
Autor:
Victoria P. Belancio, Catherine M. Ade, Rebecca S. Derbes, Sara B. Linker, Zoltán Ivics, Dawn deHaro, Bradley J. Wagstaff, Travis B. White, Astrid M. Roy-Engel
Publikováno v:
Gene. 642:188-198
DNA binding domains (DBDs) have been used with great success to impart targeting capabilities to a variety of proteins creating highly useful genomic tools. We evaluated the ability of five types of DBDs and strategies (AAV Rep proteins, Cre, TAL eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efce7d23abd0f088a39edb6958ad62e8
https://doi.org/10.1016/j.gene.2017.11.033
https://doi.org/10.1016/j.gene.2017.11.033
Autor:
Prescott L. Deininger, Victoria P. Belancio, Marc Neeland, Vincent A Streva, Travis B. White, Geraldine Servant, Rebecca S. Derbes, Astrid M. Roy-Engel, Madushani I Wijetunge
Publikováno v:
Genetics
Long interspersed elements 1 (L1) are active mobile elements that constitute almost 17% of the human genome. They amplify through a “copy-and-paste” mechanism termed retrotransposition, and de novo insertions related to these elements have been r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45dbf5f3110f16820f9d49758e30dfeb
https://doi.org/10.1534/genetics.116.188680
https://doi.org/10.1534/genetics.116.188680
Autor:
Ancha Baranova, Max Myakishev-Rempel, Olga Nazarenko, Evgeniya Kananykhina, Astrid M. Roy-Engel, Yegor Vassetsky, Oksana Polesskaya, Irina Kulemzina
Publikováno v:
Medical Hypotheses
Medical Hypotheses, Elsevier, 2018, 115, pp.29-34. ⟨10.1016/j.mehy.2018.03.008⟩
Medical Hypotheses, Elsevier, 2018, 115, pp.29-34. ⟨10.1016/j.mehy.2018.03.008⟩
Non-coding RNAs have emerged as essential contributors to neuroinflammation. The Alu element is the most abundant potential source of non-coding RNA in the human genome represented by over 1.1 million copies totaling ∼10% of the genome's mass. Accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6424b222ff1b200a3cbe0813c7343f1f
https://hal.archives-ouvertes.fr/hal-02323291
https://hal.archives-ouvertes.fr/hal-02323291
Mobile elements have significantly impacted genome structure of most organisms. The continued activity of the mobile element, LINE-1 (L1), through time has contributed to the accumulation of over half a million L1 copies in the human genome. Most cop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2406803f75fbae45470dc4933c96338
https://europepmc.org/articles/PMC6136441/
https://europepmc.org/articles/PMC6136441/