Výsledky vyhledávání - "Astrid Lague"

Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia

Autor: Mindy Farris, Jacob Statnekov, Zara Manuelyan, Astrid Lague, Christopher S. Francklyn

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 80:1095-1109

Acute Promyelocytic Leukemia (APL) results from a reciprocal translocation that fuses the gene for the PML tumor suppressor to that encoding the retinoic acid receptor alpha (RARα). The resulting PML-RARα oncogene product interferes with multiple r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ad6c3bc924afb47bfd20149dfd2410
https://doi.org/10.1002/prot.24010

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Substrate specificity and catalysis by the editing active site of alanyl-tRNA synthetase from Escherichia coli†

Autor: Astrid Lague, Zvi Pasman, Susan M. Robey-Bond, Gregory J. Smith, Adam C. Mirando, Christopher S. Francklyn

Aminoacyl-tRNA synthetases (ARSs) enhance the fidelity of protein synthesis through multiple mechanisms, including hydrolysis of the adenylate and cleavage of misacylated tRNA. Alanyl-tRNA synthetase (AlaRS) limits misacylation with glycine and serin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e883f8e57710be71c1cb2b5b64a2619
https://europepmc.org/articles/PMC3069921/

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