Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Astrid Laegreid"'
Autor:
Kathleen A. Heck, Håvard T. Lindholm, Barbara Niederdorfer, Eirini Tsirvouli, Martin Kuiper, Åsmund Flobak, Astrid Lægreid, Liv Thommesen
Publikováno v:
Proteomes, Vol 11, Iss 1, p 3 (2023)
Colorectal cancer (CRC) is one of the most prevalent cancers, driven by several factors including deregulations in intracellular signalling pathways. Small extracellular vesicles (sEVs) are nanosized protein-packaged particles released from cells, wh
Externí odkaz:
https://doaj.org/article/750dbd6bcab14f79b3d6cdf8f74b1b95
Autor:
Barbara Niederdorfer, Vasundra Touré, Miguel Vazquez, Liv Thommesen, Martin Kuiper, Astrid Lægreid, Åsmund Flobak
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Discrete dynamical modeling shows promise in prioritizing drug combinations for screening efforts by reducing the experimental workload inherent to the vast numbers of possible drug combinations. We have investigated approaches to predict combination
Externí odkaz:
https://doaj.org/article/9646a10c30a64b28b8fde52fa58f74b4
Autor:
Evelina Folkesson, Barbara Niederdorfer, Vu To Nakstad, Liv Thommesen, Geir Klinkenberg, Astrid Lægreid, Åsmund Flobak
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ee22fedb649e487bb2c164209c05ebd1
Autor:
Åsmund Flobak, Anaïs Baudot, Elisabeth Remy, Liv Thommesen, Denis Thieffry, Martin Kuiper, Astrid Lægreid
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004426 (2015)
Discovery of efficient anti-cancer drug combinations is a major challenge, since experimental testing of all possible combinations is clearly impossible. Recent efforts to computationally predict drug combination responses retain this experimental se
Externí odkaz:
https://doaj.org/article/7e5ab149cfc74114ab3d783953ef9aa2
Autor:
Linn-Karina M Selvik, Shalini Rao, Tonje S Steigedal, Ildri Haltbakk, Kristine Misund, Torunn Bruland, Wenche S Prestvik, Astrid Lægreid, Liv Thommesen
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112485 (2014)
Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced levels of SIK1 are associated w
Externí odkaz:
https://doaj.org/article/c69c5cdade9b424298d2bd7440a596f8
Autor:
Kristine Misund, Linn-Karina Myrland Selvik, Shalini Rao, Kristin Nørsett, Ingunn Bakke, Arne K Sandvik, Astrid Lægreid, Torunn Bruland, Wenche S Prestvik, Liv Thommesen
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76234 (2013)
The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the adenocarcinoma cell lines AR
Externí odkaz:
https://doaj.org/article/09195b51dd474ebe8619681cba43d42f
Autor:
Torgeir R Hvidsten, Astrid Laegreid, Andriy Kryshtafovych, Gunnar Andersson, Krzysztof Fidelis, Jan Komorowski
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6266 (2009)
BACKGROUND:Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that structural similarities may give
Externí odkaz:
https://doaj.org/article/8311e520922c4e4eb429f480212484bc
Autor:
Sophia Müller-Dott, Eirini Tsirvouli, Miguel Vázquez, Ricardo O. Ramirez Flores, Pau Badia-i-Mompel, Robin Fallegger, Astrid Lægreid, Julio Saez-Rodriguez
Gene regulation plays a critical role in the cellular processes that underlie human health and disease. The regulatory relationship between transcription factors (TFs), key regulators of gene expression, and their target genes, the so called TF regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::796be2c0ad987e449e1d5d0eff1c62fe
https://doi.org/10.1101/2023.03.30.534849
https://doi.org/10.1101/2023.03.30.534849
Publikováno v:
Medicine, Health Care, and Philosophy
In this paper, we tell the story of efforts currently underway, on diverse fronts, to build digital knowledge repositories (‘knowledge-bases’) to support research in the life sciences. If successful, knowledge bases will be part of a new knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de755eed1e99cc8917c09cc47119506
https://doi.org/10.1007/s11019-020-09957-0
https://doi.org/10.1007/s11019-020-09957-0
Autor:
Miguel Vazquez, Martin Krallinger, Florian Leitner, Martin Kuiper, Alfonso Valencia, Astrid Laegreid
Publikováno v:
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Universitat Politècnica de Catalunya (UPC)
The regulation of gene transcription by transcription factors is a fundamental biological process, yet the relations between transcription factors (TF) and their target genes (TG) are still only sparsely covered in databases. Text-mining tools can of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4809196e947b6ab03355e5f65cae3487
https://hdl.handle.net/2117/367522
https://hdl.handle.net/2117/367522