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Supplementary Figure Legends from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Autor: Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil

Supplementary figure, table and data legend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462d5da00a1ff6efad42d8684cfdb08a
https://doi.org/10.1158/1535-7163.22503118

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Supplementary Figure 2. Experiment that was used to select drug concentrations for combination screen. from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

We ran 8 titration point curves (shown in gray) and then picked 4 concentration points that cover best the response curve for all cell lines (shown in red). The first point is the top plateau, the last is the bottom plateau and the other 2 are in bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862f8c6540eb40e57d14a4dea52aef8d
https://doi.org/10.1158/1535-7163.22503121.v1

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Supplementary Data-Single Agent Response from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

raw single agent response data; response is represented as fractional viability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e031cb4d261fcd6e26d648bb72c3cb6
https://doi.org/10.1158/1535-7163.22503127.v1

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Supplementary Data-Response Legends from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Legend for raw response data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17345ab8b8dcb979c0e14049be5a3ed3
https://doi.org/10.1158/1535-7163.22503130

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Supplementary Data-Combination Response from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

raw combination response data; response is represented as fractional viability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e7b4ed58563afddecfe4b34e5c8724
https://doi.org/10.1158/1535-7163.22503133

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Supplementary Figure 1. Hierarchical clustering of response to single agent treatments. from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Hierarchical clustering was performed on the response data across the cell line panel to the single agent treatments. Drugs with similar mechanisms of action clustered together.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81be606582d3fac41ce63bfe6170eb3b
https://doi.org/10.1158/1535-7163.22503124.v1

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Supplemental Table 1. Thirty-nine cell lines used in combination screen. from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

RAS mutation/signature does not predict response to mTOR/Wee1 combination.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad3fa32b2e0aa96bdf6bf82d7a0e736
https://doi.org/10.1158/1535-7163.22503139.v1

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Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

Autor: Astrid Kral, Herman Yeger, Jerry Pelletier, Elise A. Rose, Carol Jones, William H. Lewis, Caryn Y. Ito, Daniel A. Haber, David E. Housman, Katherine M. Call, Alan Buckler, Thomas M Glaser

Publikováno v: Cell. 60(3)

We have isolated a series of genomic and cDNA clones mapping within the boundaries of constitutional and tumor deletions that define the Wilms' tumor locus on human chromosome 11 (band p13). The transcription unit corresponding to these clones spans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4877cbe82f7104c38e5a6eda1351df2c
https://pubmed.ncbi.nlm.nih.gov/2154335

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