Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Astrid Kassner"'
Autor:
Verena Hugenberg, Marion Zerna, Mathias Berndt, Reinhard Zabel, Rainer Preuss, Dirk Rolfsmeier, Janet Wegener, Henrik Fox, Astrid Kassner, Hendrik Milting, Norman Koglin, Andrew W. Stephens, Jan F. Gummert, Wolfgang Burchert, Marcus-André Deutsch
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 739 (2021)
Thrombus formation and thromboembolic events play important roles in various cardiovascular pathologies. The key receptor involved in platelet aggregation is the fibrinogen receptor glycoprotein IIb/IIIa. [18F]GP1, a derivative of the GPIIb/IIIa anta
Externí odkaz:
https://doaj.org/article/da912480adb4441386fc01f3701bd89b
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169896 (2017)
In terminal failing hearts ventricular assist devices (VAD) are implanted as a bridge to transplantation. Endothelin receptor (ETR) antagonists are used for treatment of secondary pulmonary hypertension in VAD patients. However, the cardiac ETR regul
Externí odkaz:
https://doaj.org/article/b1d426a4858f4b90877a85360bb98ea1
Autor:
Baerbel Klauke, Anna Gaertner-Rommel, Uwe Schulz, Astrid Kassner, Edzard Zu Knyphausen, Thorsten Laser, Deniz Kececioglu, Lech Paluszkiewicz, Ute Blanz, Eugen Sandica, Antoon J van den Bogaerdt, J Peter van Tintelen, Jan Gummert, Hendrik Milting
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189489 (2017)
Cardiomyopathies might lead to end-stage heart disease with the requirement of drastic treatments like bridging up to transplant or heart transplantation. A not precisely known proportion of these diseases are genetically determined. We genotyped 43
Externí odkaz:
https://doaj.org/article/40583a7115ce40dbbbcc0998575edc8c
Autor:
Anna Gaertner, Jens Tiesmeier, Caroline Stanasiuk, Astrid Kassner, Philipp Sommer, Hendrik Milting, Kai-Thorsten Laser, Jan Gummert, Uwe Schulz, Karl-Otto Dubowy, Elina Felski, Baerbel Klauke, Andreas Brodehl, Henrik Fox, Hendrik Bante, Leonard Bergau, Hans Ebbinghaus, Désirée Gerdes, Michiel Morshuis
Publikováno v:
Human Mutation. 41:1931-1943
Mutations in RBM20 encoding the RNA-binding motif protein 20 (RBM20) are associated with an early onset and clinically severe forms of cardiomyopathies. Transcriptome analyses revealed RBM20 as an important regulator of cardiac alternative splicing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896744b183e284e28c71e70d55fb92d0
https://doi.org/10.1002/humu.24096
https://doi.org/10.1002/humu.24096
Autor:
Jan Gummert, Anna Hucke, Alexander Goedel, Astrid Kassner, Hendrik Milting, Izabela Tuleta, Wolfgang A. Linke, Andrey Fomin, Katrin Streckfuß-Bömeke, Anna Gärtner, Norbert Hubner, Holger Reinecke, Cristobal G. dos Remedios, Lina Folsche, Alessandra Moretti, Ralph Knöll, Gerd Hasenfuss, Katharina Sielemann, Sebastiaan van Heesch, Luisa Wellers, Malte Tiburcy, Anastasia J. Hobbach, Lukas Cyganek, Wolfram H. Zimmermann, Franziska Koser, Karl-Ludwig Laugwitz, Andreas Unger, Marion von Frieling-Salewsky
Publikováno v:
Science Translational Medicine. 13
Stable expression of truncated titin proteins and titin haploinsufficiency characterize TTN cardiomyopathy and represent targets for therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a191aabca65731cb00a94038bff0f52d
https://doi.org/10.1126/scitranslmed.abd3079
https://doi.org/10.1126/scitranslmed.abd3079
Autor:
Andrey, Fomin, Anna, Gärtner, Lukas, Cyganek, Malte, Tiburcy, Izabela, Tuleta, Luisa, Wellers, Lina, Folsche, Anastasia J, Hobbach, Marion, von Frieling-Salewsky, Andreas, Unger, Anna, Hucke, Franziska, Koser, Astrid, Kassner, Katharina, Sielemann, Katrin, Streckfuß-Bömeke, Gerd, Hasenfuss, Alexander, Goedel, Karl-Ludwig, Laugwitz, Alessandra, Moretti, Jan F, Gummert, Cristobal G, Dos Remedios, Holger, Reinecke, Ralph, Knöll, Sebastiaan, van Heesch, Norbert, Hubner, Wolfram H, Zimmermann, Hendrik, Milting, Wolfgang A, Linke
Publikováno v:
Science translational medicine. 13(618)
Heterozygous truncating variants in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69b2bb236f5a569e431a7bbe506f056b
https://pubmed.ncbi.nlm.nih.gov/34799709
https://pubmed.ncbi.nlm.nih.gov/34799709
Autor:
Jens Tiesmeier, Ralph Knoell, Jan Gummert, Henrik Fox, Anna Gaertner, Astrid Kassner, Hendrik Milting, Baerbel Klauke, Uwe Schulz, Michiel Morshuis, Julia Bloebaum, Andreas Brodehl, Katharina Sielemann
Publikováno v:
Genes, Vol 12, Iss 883, p 883 (2021)
Genes
Volume 12
Issue 6
Genes
Volume 12
Issue 6
A major cause of heart failure is cardiomyopathies, with dilated cardiomyopathy (DCM) as the most common form. Over 40 genes are linked to DCM, among them TTN and RBM20. Next Generation Sequencing in clinical DCM cohorts revealed truncating variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99538f94c887365d68ec59eec9933fed
https://www.mdpi.com/2073-4425/12/6/883
https://www.mdpi.com/2073-4425/12/6/883
Autor:
Christoph Kuppe, Ricardo O. Ramirez Flores, Zhijian Li, Sikander Hayat, Rebecca T. Levinson, Xian Liao, Monica T. Hannani, Jovan Tanevski, Florian Wünnemann, James S. Nagai, Maurice Halder, David Schumacher, Sylvia Menzel, Gideon Schäfer, Konrad Hoeft, Mingbo Cheng, Susanne Ziegler, Xiaoting Zhang, Fabian Peisker, Nadine Kaesler, Turgay Saritas, Yaoxian Xu, Astrid Kassner, Jan Gummert, Michiel Morshuis, Junedh Amrute, Rogier J. A. Veltrop, Peter Boor, Karin Klingel, Linda W. Van Laake, Aryan Vink, Remco M. Hoogenboezem, Eric M. J. Bindels, Leon Schurgers, Susanne Sattler, Denis Schapiro, Rebekka K. Schneider, Kory Lavine, Hendrik Milting, Ivan G. Costa, Julio Saez-Rodriguez, Rafael Kramann
Publikováno v:
Nature
Nature, 608(7924), 766-777. Nature Publishing Group
Nature, 608(7924), 766-777. Nature Publishing Group
Myocardial infarction is a leading cause of death worldwide1. Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited the effectiveness of therapies to reduce late-stage mortality2. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1188d2cc4abb14f23887e2ac9e352488
https://pubmed.ncbi.nlm.nih.gov/36214046
https://pubmed.ncbi.nlm.nih.gov/36214046
Autor:
G Erkilet, Astrid Kassner, Armin Zittermann, Hendrik Milting, Jan Gummert, W. Prohaska, C. Oezpeker, Michel Morshuis, Daniela Baurichter
Publikováno v:
Journal of Cardiac Surgery. 33:693-702
BACKGROUND The associations between mechanical circulatory support (MCS), acquired von Willebrand syndrome (AvWS), and clinical outcome are incompletely understood. METHODS In 128 heart failure patients with pulsatile MCS implants (65 total artificia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e5003d8cf9cdc2e500f3b6df2585db
https://doi.org/10.1111/jocs.13794
https://doi.org/10.1111/jocs.13794
Autor:
Sebastian Kant, Rudolf E. Leube, Astrid Kassner, Mustafa Gerçek, Hendrik Milting, Elisa A. Liehn, Muhammed Gerçek, Claudia A. Krusche, Sakine Simsekyilmaz
Publikováno v:
The American Journal of Pathology. 187:752-766
Arrhythmogenic cardiomyopathy (AC) is a hereditary disease leading to sudden cardiac death or heart failure. AC pathology is characterized by cardiomyocyte loss and replacement fibrosis. Our goal was to determine whether cardiomyocytes respond to AC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00e7a0074f414387b73b8fc9f77795d
https://doi.org/10.1016/j.ajpath.2016.12.018
https://doi.org/10.1016/j.ajpath.2016.12.018