Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Astrid Jussofie"'
Publikováno v:
Free Radical Biology and Medicine. 25:712-719
We investigated the mechanism by which H 2 O 2 mediates an increase in [Na + ] i in L929 cells and the relevance of this Na + load for H 2 O 2 -induced cell injury. [Na + ] i increased early after exposure to H 2 O 2 as monitored by fluorescence spec
Autor:
Astrid Jussofie
Publikováno v:
Developmental Neuroscience. 17:335-342
The ontogenetic development of Γ-aminobutyric acid type A (GABAA) receptors and their sensitivity to neuroactive steroid agonists were determined between birth and day 25 postnatally
Publikováno v:
Journal of Liquid Chromatography. 16:447-463
A robust procedure with minimal tissue sample pretreatment, based on reversed-phase, ion-pair high performance liquid chromatography (HPLC) combined with electrochemical detection has been developed for the automated and simultaneous determination of
Autor:
Astrid Jussofie
Publikováno v:
Biological Chemistry Hoppe-Seyler. 374:61-68
A new procedure for tissue preparation is described for the study of modulatory effects of neuroactive steroids and barbiturates on the in vitro binding of [3H]muscimol in distinct areas of rat brain. This method had been optimized for the highest am
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:561-564
A procedure for the biosynthetic preparation of 3α-hydroxy-5α-[1,2,6,7-3H]-pregnan-20-one (3H-HPO) with high specific activity convenient for binding studies was developed. 3H-HPO was synthesized from [1,2,6,7-3H]progesterone using a microsomal pre
Publikováno v:
Journal of neuroendocrinology. 3(3)
The narcotically active progesterone metabolite 3alpha-hydroxy-5alpha-pregnan-20-one (HPO) modulates gamma-aminobutyric acid (GABA) neurotransmission by direct actions on the GABA(A)-receptor complex. In the present investigation, the formation of HP
Autor:
Gersham W. Dent, Bożena Gabryel, Paweł Cieslik, Gail B. Pearsall, Merrill K. Wolf, Priscilla Lane, Peter A. Wilce, Steven E. Shelton, Melissa P. Wasserstein, Tatsumi Hirata, Narayan R. Bhat, Jeevajothie Karthigasan, Artur Kozłowski, Vanya Quiñones-Jenab, Shin Takagi, Joel G. Turner, Susan Billings-Gagliardi, Hajime Fujisawa, Errol B. De Souza, W.J. Streit, Dimitri E. Grigoriadis, Anna Pudełko, Sally Meiners, Daniel A. Kirschner, Izuru Matsumoto, Herbert M. Geller, Hideo Uno, S.D. Hurley, Henryk I. Trzeciak, Maria Marone, W.A. Long, Shu-Yin Ho, Zac Pujic, T. Segreti, Andrzej Małecki, J.L. Gingras, Lynn M. DiBenedetto, Richard S. Nowakowski, Astrid Jussofie, Ned H. Kalin, Nancy L. Nadon
Publikováno v:
Developmental Neuroscience. 17:371-373
Autor:
Astrid Jussofie
Publikováno v:
Acta endocrinologica. 129(5)
Regional differences in the effects of neuroactive steroids on the GABAA receptor complex have been demonstrated in vitro (1–3). In order to elucidate if a regionally different modulation of the GABA-binding site also occurs after acute steroidal t
Autor:
Astrid Jussofie
Publikováno v:
Biological chemistry Hoppe-Seyler. 374(4)
The allosteric regulation of specific [3H]-muscimol binding by neuroactive steroids to the GABA-binding sites of membrane fractions prepared from five different brain areas was characterized in order to elucidate if the regionally variable subunit co
Autor:
Artur Kozłowski, Joel G. Turner, S.D. Hurley, T. Segreti, Errol B. De Souza, Gail B. Pearsall, Tatsumi Hirata, Ned H. Kalin, Daniel A. Kirschner, Melissa P. Wasserstein, Hajime Fujisawa, Maria Marone, W.A. Long, Hideo Uno, Gersham W. Dent, Priscilla Lane, Peter A. Wilce, Shu-Yin Ho, Susan Billings-Gagliardi, Izuru Matsumoto, Nancy L. Nadon, Jeevajothie Karthigasan, Vanya Quiñones-Jenab, Herbert M. Geller, W.J. Streit, Zac Pujic, J.L. Gingras, Lynn M. DiBenedetto, Steven E. Shelton, Merrill K. Wolf, Shin Takagi, Anna Pudełko, Sally Meiners, Dimitri E. Grigoriadis, Astrid Jussofie, Henryk I. Trzeciak, Andrzej Małecki, Paweł Cieslik, Richard S. Nowakowski, Bożena Gabryel, Narayan R. Bhat
Publikováno v:
Developmental Neuroscience. 17:369-370