Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Astrid Hoermann"'
Autor:
David A Ellis, George Avraam, Astrid Hoermann, Claudia A S Wyer, Yi Xin Ong, George K Christophides, Nikolai Windbichler
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010244 (2022)
Gene drives for mosquito population modification are novel tools for malaria control. Strategies to safely test antimalarial effectors in the field are required. Here, we modified the Anopheles gambiae zpg locus to host a CRISPR/Cas9 integral gene dr
Externí odkaz:
https://doaj.org/article/4f2a9067ca88473e8c96c7fdaa87dcac
Autor:
Alexander Nash, Paolo Capriotti, Astrid Hoermann, Phillipos Aris Papathanos, Nikolai Windbichler
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Gene drives are promising tools for the genetic control of insect vector or pest populations. CRISPR-based gene drives are generally highly complex synthetic constructs consisting of multiple transgenes and their respective regulatory elements. This
Externí odkaz:
https://doaj.org/article/bc3e21ba59c64e90bedb328b25fa7456
Autor:
Tibebu Habtewold, Sofia Tapanelli, Ellen K. G. Masters, Astrid Hoermann, Nikolai Windbichler, George K. Christophides
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background The development of malaria transmission-blocking strategies including the generation of malaria refractory mosquitoes to replace the wild populations through means of gene drives hold great promise. The standard membrane feeding a
Externí odkaz:
https://doaj.org/article/31022306460f4a268da65420c208390f
Autor:
Astrid Hoermann, Sofia Tapanelli, Paolo Capriotti, Giuseppe Del Corsano, Ellen KG Masters, Tibebu Habtewold, George K Christophides, Nikolai Windbichler
Publikováno v:
eLife, Vol 10 (2021)
Gene drives for mosquito population replacement are promising tools for malaria control. However, there is currently no clear pathway for safely testing such tools in endemic countries. The lack of well-characterized promoters for infection-relevant
Externí odkaz:
https://doaj.org/article/50a54b8e2a82416782af4d09c021733c
Autor:
Anna B. Ziegler, Christoph Thiele, Federico Tenedini, Mélisande Richard, Philipp Leyendecker, Astrid Hoermann, Peter Soba, Gaia Tavosanis
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3346-3353 (2017)
Summary: During differentiation, neurons require a high lipid supply for membrane formation as they elaborate complex dendritic morphologies. While glia-derived lipids support neuronal growth during development, the importance of cell-autonomous lipi
Externí odkaz:
https://doaj.org/article/a1ba31ee0edc4a04921306addebd4441
Autor:
Alexander Nash, Giulia Mignini Urdaneta, Andrea K. Beaghton, Astrid Hoermann, Philippos Aris Papathanos, George K. Christophides, Nikolai Windbichler
Publikováno v:
Biology Open, Vol 8, Iss 1 (2019)
A first generation of CRISPR-based gene drives has now been tested in the laboratory in a number of organisms, including malaria vector mosquitoes. Challenges for their use in the area-wide genetic control of vector-borne disease have been identified
Externí odkaz:
https://doaj.org/article/a12c7d2743e94064966ae06e8026740b
Autor:
Kolja Becker, Eva Balsa-Canto, Damjan Cicin-Sain, Astrid Hoermann, Hilde Janssens, Julio R Banga, Johannes Jaeger
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 10, p e1003281 (2013)
Systems biology proceeds through repeated cycles of experiment and modeling. One way to implement this is reverse engineering, where models are fit to data to infer and analyse regulatory mechanisms. This requires rigorous methods to determine whethe
Externí odkaz:
https://doaj.org/article/4615887f1a25471f865fc37c33c580c8
Autor:
Astrid, Hoermann, Tibebu, Habtewold, Prashanth, Selvaraj, Giuseppe, Del Corsano, Paolo, Capriotti, Maria Grazia, Inghilterra, Temesgen M, Kebede, George K, Christophides, Nikolai, Windbichler
Publikováno v:
Science advances. 8(38)
Gene drives hold promise for the genetic control of malaria vectors. The development of vector population modification strategies hinges on the availability of effector mechanisms impeding parasite development in transgenic mosquitoes. We augmented a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe9972cff45b322389f424d0a01160e0
https://pubmed.ncbi.nlm.nih.gov/36129981
https://pubmed.ncbi.nlm.nih.gov/36129981
Autor:
Giuseppe Del Corsano, Astrid Hoermann, Nikolai Windbichler, Paolo Capriotti, Ellen K. G. Masters, George K. Christophides, Sofia Tapanelli, Tibebu Habtewold
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Gene drives for mosquito population replacement are promising tools for malaria control. However, there is currently no clear pathway for safely testing such tools in endemic countries. The lack of well-characterized promoters for infection-relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e3d9427ae74955ab5d1366d1edf2b7
http://hdl.handle.net/10044/1/91679
http://hdl.handle.net/10044/1/91679
Autor:
George K. Christophides, Tibebu Habtewold, Nikolai Windbichler, Paolo Capriotti, Ellen K. G. Masters, Giuseppe Del Corsano, Sofia Tapanelli, Astrid Hoermann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::178d33e2c876ea0fc6660fe2982bed73
https://doi.org/10.7554/elife.58791.sa2
https://doi.org/10.7554/elife.58791.sa2