Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Astrid Grottke"'
Autor:
Joanna Kempska, Leticia Oliveira-Ferrer, Astrid Grottke, Minyue Qi, Malik Alawi, Felix Meyer, Kerstin Borgmann, Fabienne Hamester, Kathrin Eylmann, Maila Rossberg, Daniel J. Smit, Manfred Jücker, Elena Laakmann, Isabell Witzel, Barbara Schmalfeldt, Volkmar Müller, Karen Legler
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe PI3K/AKT pathway is activated in 43-70% of breast cancer (BC)-patients and promotes the metastatic potential of BC cells by increasing cell proliferation, invasion and radioresistance. Therefore, AKT1-inhibition in combination with ra
Externí odkaz:
https://doaj.org/article/7882ba2141484a4e949b72c38b608411
Autor:
Astrid Grottke, Florian Ewald, Tobias Lange, Dominik Nörz, Christiane Herzberger, Johanna Bach, Nicole Grabinski, Lareen Gräser, Frank Höppner, Björn Nashan, Udo Schumacher, Manfred Jücker
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146370 (2016)
BACKGROUND:Treatment of breast cancer patients with distant metastases represents one of the biggest challenges in today's gynecological oncology. Therefore, a better understanding of mechanisms promoting the development of metastases is of paramount
Externí odkaz:
https://doaj.org/article/4dd5f082c1ae47c386c9ebe8a20cf57c
Autor:
Marina Holler, Astrid Grottke, Katharina Mueck, Julia Manes, Manfred Jücker, H Peter Rodemann, Mahmoud Toulany
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154745 (2016)
Inhibition of mammalian target of rapamycin-complex 1 (mTORC1) induces activation of Akt. Because Akt activity mediates the repair of ionizing radiation-induced DNA double-strand breaks (DNA-DSBs) and consequently the radioresistance of solid tumors,
Externí odkaz:
https://doaj.org/article/9255faa5f6614ad996606be7dfcfe321
Autor:
Barbara Schmalfeldt, Linn Woelber, Maxine Biermann, Donata Grimm, Astrid Grottke, Anna Jaeger, Johannes Salamon, Katharina Prieske, Cordula Petersen, Volkmar Mueller
Publikováno v:
Archives of Gynecology and Obstetrics. 301:327-332
Distant metastases from squamous cell cancer of the vulva (VSCC) are encountered rarely and are associated with a poor prognosis. Cerebral metastases have only been described anecdotally. A 51-year old woman was diagnosed with hepatic metastases due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea65a3e822c6abbd05528357d2ba541
https://doi.org/10.1007/s00404-019-05403-6
https://doi.org/10.1007/s00404-019-05403-6
Publikováno v:
Cellular signalling. 93
Acute lymphoblastic leukemia is the most common cause of cancer-related death in children and, especially for patients in a high-risk group, still represents a poor prognosis. The PI3K/AKT/mTOR signaling pathway has been identified as a frequently co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eac32cc1ba1490656aebb1e3d97f45b
https://pubmed.ncbi.nlm.nih.gov/35259456
https://pubmed.ncbi.nlm.nih.gov/35259456
Publikováno v:
Senologie - Zeitschrift für Mammadiagnostik und -therapie. 15:213-218
The incidence of breast cancer brain metastases has risen steadily in recent years. Brain metastases are often the limiting factor of the disease, as survival is usually only a few months after brain metastasis occurs. Apart from the poor prognosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85208b5437bc4236ef51eecce49b609
https://doi.org/10.1055/a-0753-3504
https://doi.org/10.1055/a-0753-3504
Autor:
Stefan Werner, Tobias Pukrop, Kai Bartkowiak, Stefan Horn, Manfred Jücker, Klaus Pantel, Alexander Schulte, Manfred Westphal, Katrin Lamszus, Markus Glatzel, Astrid Grottke, Harriet Wikman, Isabell Witzel, Jakob Matschke, Ina Hohensee, Han-Ning Chuang
Publikováno v:
Oncotarget
// Ina Hohensee 1 , Han-Ning Chuang 2, * , Astrid Grottke 3, * , Stefan Werner 1 , Alexander Schulte 4 , Stefan Horn 5 , Katrin Lamszus 4 , Kai Bartkowiak 1 , Isabell Witzel 6 , Manfred Westphal 4 , Jakob Matschke 7 , Markus Glatzel 7 , Manfred Jucke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606f49127e6244afd1a538c0d82da1c6
http://europepmc.org/articles/PMC5351620
http://europepmc.org/articles/PMC5351620
Autor:
Johanna Bach, Manfred Jücker, Christiane Herzberger, Dominik Nörz, Astrid Grottke, Florian Ewald, Björn Nashan, Bianca T. Hofmann
Publikováno v:
Cellular Signalling. 27:2191-2200
Background Development of small molecular inhibitors against BRAF and MEK has been a breakthrough in the treatment of malignant melanoma. However, the long-term effect is foiled in virtually all patients by the emergence of resistant tumor cell popul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2745f9103bb900993716b285110964c5
https://doi.org/10.1016/j.cellsig.2015.07.016
https://doi.org/10.1016/j.cellsig.2015.07.016
Autor:
Jakob R. Izbicki, Alexander Schultze, Manfred Jücker, Maxim Kebenko, Astrid Grottke, Nicole Grabinski, Astrid Drenckhan, Florian Ewald, Carsten Bokemeyer, Walter Fiedler, Jasmin Wellbrock, Stephanie J. Gros
Publikováno v:
Cellular Signalling. 27:373-381
The Hedgehog pathway plays an important role in the pathogenesis of several tumor types, including esophageal cancer. In our study, we show an expression of the ligand Indian hedgehog (Ihh) and its downstream mediator Gli-1 in primary resected adenoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3609bef611271d9cd8c4a7da19de0c34
https://doi.org/10.1016/j.cellsig.2014.11.022
https://doi.org/10.1016/j.cellsig.2014.11.022
Autor:
Björn Nashan, Christiane Herzberger, Dominik Nörz, Bianca T. Hofmann, Florian Ewald, Manfred Jücker, Astrid Grottke, Johanna Bach
Publikováno v:
Journal of Cancer
Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a122ee82aa1c93d89d8394eed7b37f04
https://doi.org/10.7150/jca.12452
https://doi.org/10.7150/jca.12452