A unique immune signature in blood separates therapy-refractory from therapy-responsive acute graft-versus-host disease

Autor: Astrid G. S. van Halteren, Jessica S. Suwandi, Sander Tuit, Jelske Borst, Sandra Laban, Roula Tsonaka, Ada Struijk, Anna-Sophia Wiekmeijer, Melissa van Pel, Bart O. Roep, Jaap Jan Zwaginga, Arjan C. Lankester, Koen Schepers, Maarten J. D. van Tol, Willem E. Fibbe

Publikováno v: Blood. 141(11):1277-1292

Acute graft-versus-host disease (aGVHD) is an immune cell‒driven, potentially lethal complication of allogeneic hematopoietic stem cell transplantation affecting diverse organs, including the skin, liver, and gastrointestinal (GI) tract. We applied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4806f577f9ab625e12cf2e9aa317027
https://doi.org/10.1182/blood.2022015734

Apparent Lack of BRAFV600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8+ T Cells in Langerhans Cell Histiocytosis

Autor: Paul G. Kemps, Timo C. Zondag, Eline C. Steenwijk, Quirine Andriessen, Jelske Borst, Sandra Vloemans, Dave L. Roelen, Lenard M. Voortman, Robert M. Verdijk, Carel J. M. van Noesel, Arjen H. G. Cleven, Cynthia Hawkins, Veronica Lang, Arnoud H. de Ru, George M. C. Janssen, Geert W. Haasnoot, Kees L. M. C. Franken, Ronald van Eijk, Nienke Solleveld-Westerink, Tom van Wezel, R. Maarten Egeler, Auke Beishuizen, Jan A. M. van Laar, Oussama Abla, Cor van den Bos, Peter A. van Veelen, Astrid G. S. van Halteren

Publikováno v: Frontiers in Immunology, Vol 10 (2020)

Langerhans Cell Histiocytosis (LCH) is a neoplastic disorder of hematopoietic origin characterized by inflammatory lesions containing clonal histiocytes (LCH-cells) intermixed with various immune cells, including T cells. In 50–60% of LCH-patients,

Externí odkaz: https://doaj.org/article/e72482c223694d18a86b7155b95eb24c

Successful mismatched hematopoietic stem cell transplantation for pediatric hemoglobinopathy by using ATG and post-transplant cyclophosphamide

Autor: Anja M. Jansen-Hoogendijk, Astrid G. S. van Halteren, Robbert G. M. Bredius, Maarten J. D. van Tol, Alexander B. Mohseny, Lisa V E Oostenbrink, Emma S. Pool, Arjan C. Lankester, Cornelia M. Jol-van der Zijde, Frans J. Smiers, Carly Vervat, Marco W. Schilham

Publikováno v: Bone Marrow Transplantation. SPRINGERNATURE
Bone Marrow Transplantation

The use of HLA-mismatched (un)related donors is historically associated with a higher incidence of transplant-related complications and mortality. However, the use of such donors may overcome the limited availability of HLA-matched donors for patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38207222d3da57c4be2cd535e0994a48
https://doi.org/10.1038/s41409-021-01302-0

ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition

Autor: Oussama Abla, Stephen Peeke, Irem Eldem, Marianne D. van de Wetering, Jennifer Picarsic, Kseniya Petrova-Drus, Robert B. Lorsbach, Jan A M van Laar, Paul Geraeds Kemps, Sylvie Fraitag, Sébastien Héritier, Kristian T. Schafernak, Amy A. Swanson, Eli L. Diamond, Raf Sciot, Karen Ernestus, Mariko Suchi, Nabeel R. Yaseen, Sanda Alexandrescu, Laura Sophia Hiemcke-Jiwa, Matthew Collin, Ingrid S Tam, Sabrina Rossi, Benjamin H. Durham, F J Sherida H Woei-A-Jin, James A. Whitlock, Brianna Empringham, Laura Munoz-Arcos, Falko Fend, Olga Gryniewicz-Kwiatkowska, Majid Madni, Verena Wiegering, Kerry Turner, Dina El Demellawy, Gianpiero Tamburrini, Aditya Raghunathan, Lucas R. Massoth, Carel J. M. van Noesel, Robert Möhle, Cor van den Bos, Jacinthe Bonneau-Lagacherie, Somak Roy, Pasquale M Barbaro, Andreas Beilken, Stefania Gaspari, Jean-François Emile, David D. Grier, Claire Lamaison, Kee Kiat Yeo, Jean Donadieu, Jon M Brandt, Laure Farnault, Friedrich Feuerhake, Marie-Laure Jullie, Uta Flucke, Pancras C.W. Hogendoorn, Astrid G. S. van Halteren, Antje Bornemann, Bryan A. Sisk, Tina Méry, Joanna Weinstein, Ashish R Kumar, Robert M. Verdijk, V. Baykov, Alysa A Poulin, Mandy M Atkinson, VG Potapenko, Vaish Sridhar, Julien Haroche, Zofia Hélias-Rodzewicz, Shipra Garg, Susan Picton, Michael M. Henry, Jackie Allotey, Daniel Leino, Nishant Tiwari, Martin Ebinger, Jason L Hornick, Bożenna Dembowska-Bagińska, Marco Gessi, Dmitry A Evseev

Publikováno v: Blood
Blood, 139(2), 256-280. AMER SOC HEMATOLOGY
Blood, 139(2), 256-280. American Society of Hematology
Blood, 2022, 139 (2), pp.256-280. ⟨10.1182/blood.2021013338⟩
Blood, 139, 256-280
Blood, 139, 2, pp. 256-280

Contains fulltext : 249882.pdf (Publisher’s version ) (Closed access) ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in 3 infants with multisystemic disease involving the liver and hematopoietic system.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe217ff12356ba76b44d2d33c6d436e
https://hdl.handle.net/1887/3563700

HY immune tolerance is common in women without male offspring.

Autor: Miranda P Dierselhuis, Ewa Jankowska-Gan, Els Blokland, Jos Pool, William J Burlingham, Astrid G S van Halteren, Els Goulmy

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91274 (2014)

Sex difference is an established risk factor for hematopoietic stem cell transplantation (HSCT)-related complications like graft versus host disease (GVHD). CD8pos cytotoxic T cells specific for Y chromosome-encoded minor Histocompatibility antigens

Externí odkaz: https://doaj.org/article/014d146200644273897296edba74785e