Výsledky vyhledávání - "Astrid Frazer"

The effect of suramin on the resorption of bovine nasal cartilage

Autor: Claire L. Lewis, R. Graham G. Russell, Rowena A.D. Bunning, Astrid Frazer

Publikováno v: Inflammopharmacology. 7:387-400

Suramin is an anti-neoplastic drug. Its actions include the inhibition of binding of urokinase-type plasminogen activator (uPA) to its receptor, an event which may prevent cartilage breakdown. The aim of this work was to determine the effect of suram

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebaa2469c1d29d1681ba0b8b3c98f42
https://doi.org/10.1007/s10787-999-0032-x

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Effects of growth factors and interleukin-1 alpha on proteoglycan and type II collagen turnover in bovine nasal and articular chondrocyte pellet cultures

Autor: L. D. Kozaci, Anthony P. Hollander, Roslin Russell, Astrid Frazer, Babatunde O. Oyajobi, C. Xu

Publikováno v: Endocrinology. 137:3557-3565

The aim of this study was to investigate the effects of insulin-like growth factor-I, transforming growth factor-beta (TGF-beta), and interluekin-1 alpha (IL-1 alpha) on the deposition and degradation of a cartilage-like matrix in high-density pellet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3312f637ba026e1e9899e1ccc729806
https://doi.org/10.1210/endo.137.8.8754787

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Chondrogenesis in the regenerating antler tip in red deer: Expression of collagen types I, IIA, IIB, and X demonstrated by in situ nucleic acid hybridization and immunocytochemistry

Autor: Babatunde O. Oyajobi, Andrew M. Nalin, Astrid Frazer, R. Graham G. Russell, Joanna S. Price, Linda J. Sandell

Publikováno v: Developmental Dynamics. 205:332-347

The annual regrowth of antlers in male deer is a unique example of complete bone regeneration occurring in an adult animal. Growth is initiated at the distal antler tip, which is similar to the epiphyseal growth plate in some respects. However, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f1aa5374c7c3b94245f3dce1a99de7e
https://doi.org/10.1002/(sici)1097-0177(199603)205:3<332::aid-aja12>3.0.co

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Studies on type II collagen and aggrecan production in human articular chondrocytes in vitro and effects of transforming growth factor-β and interleukin-1β

Autor: M Thavarajah, Astrid Frazer, Rowena A.D. Bunning, J. M. Seid, Roslin Russell

Publikováno v: Osteoarthritis and Cartilage. 2:235-245

Type II collagen and aggrecan are major components of the extracellular matrix of articular cartilage. Their biosynthesis and catabolism are regulated by chondrocytes. They may be used as markers of chondrocyte phenotype for cells cultured in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e302afd50c25019852f383dff690a74
https://doi.org/10.1016/s1063-4584(05)80075-5

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Effects of transforming growth factor β and interleukin-1β on [3H]thymidine incorporation by human articular chondrocytes in vitro

Autor: Rowena A.D. Bunning, R. Graham G. Russell, Astrid Frazer

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1226:193-200

This is a study of the regulation of human articular chondrocyte proliferation by transforming growth factor beta (TGF beta) and interleukin-1 beta (IL-1 beta) in vitro. Human articular chondrocytes were cultured at different cell densities on plasti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87507c2d6f130688faf7fc0393d9d8c
https://doi.org/10.1016/0925-4439(94)90028-0

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Detection of mRNA for the transforming growth factor β family in human articular chondrocytes by the polymerase chain reaction

Autor: H. Bentley, J. M. Seid, Rowena A.D. Bunning, Astrid Frazer, Roslin Russell, K. A. Hart

Publikováno v: Biochemical and Biophysical Research Communications. 180:602-608

The Transforming Growth Factor-beta (TGF beta) family of polypeptides elicits diverse biological actions on a wide range of cell types. There are known to be several isoforms of TGF beta coded for by different genes, with possibly differential expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5f314fe6f94b48275781a377675a35
https://doi.org/10.1016/s0006-291x(05)81108-8

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Expression of type X collagen and matrix calcification in three-dimensional cultures of immortalized temperature-sensitive chondrocytes derived from adult human articular cartilage

Autor: Anthony P. Hollander, Paul V. Hatton, R. Graveley, A. Houghton, Babatunde O. Oyajobi, B.M.J. Stringer, R. Graham G. Russell, Astrid Frazer, Chi Xu

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 13(3)

Chondrocytes isolated from normal adult human articular cartilage were infected with a retroviral vector encoding a temperature-sensitive mutant of the simian virus 40 large tumor antigen and a linked geneticin (G418)-resistance marker. G418-resistan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef31570975d11738df47ce8dfcd0a09
https://pubmed.ncbi.nlm.nih.gov/9525344

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Localization of Type VI Collagen in Tissue-Engineered Cartilage on Polymer Scaffolds

Autor: Astrid Frazer, Sarah Fraser, Ian M. Brook, Sally C. Dickinson, Anthony P. Hollander, Paul V. Hatton, Aileen Crawford

Publikováno v: Tissue Engineering. :060317120837007

Together, the chondrocyte and its pericellular matrix have been collectively termed the chondron. Current opinion is that the pericellular matrix has both protective and signalling functions between chondrocyte and extracellular matrix. Formation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fa94fb52b78bb4c80e35388684b4f1
https://doi.org/10.1089/ten.2006.12.ft-45

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