Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Astrid E. Alewijnse"'
Autor:
Petra Keul, Marcel M. G. J. van Borren, Alexander Ghanem, Frank Ulrich Müller, Antonius Baartscheer, Arie O. Verkerk, Frank Stümpel, Jan Sebastian Schulte, Nazha Hamdani, Wolfgang A. Linke, Pieter van Loenen, Marek Matus, Wilhelm Schmitz, Jörg Stypmann, Klaus Tiemann, Jan‐Hindrik Ravesloot, Astrid E. Alewijnse, Sven Hermann, Léon J. A. Spijkers, Karl‐Heinz Hiller, Deron Herr, Gerd Heusch, Michael Schäfers, Stephan L. M. Peters, Jerold Chun, Bodo Levkau
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 5 (2016)
BackgroundSphingosine‐1‐phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia–reperfusion injury, and ischemic preconditioning. The function of the cardiomyocyte sphingosine‐1‐phosphate receptor 1 (S1P1) in vivo is un
Externí odkaz:
https://doaj.org/article/fbf5ff26565e41e1860b0d2d29621773
Autor:
Kathinka W E M van Hooren, Léon J A Spijkers, Dorothee van Breevoort, Mar Fernandez-Borja, Ruben Bierings, Jaap D van Buul, Astrid E Alewijnse, Stephan L M Peters, Jan Voorberg
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91346 (2014)
Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells. S1P promotes endothelial cell barrier function and induces release of endothelia
Externí odkaz:
https://doaj.org/article/ecb94040bd484e56aacf2e23ee062e9c
Autor:
Léon J A Spijkers, Rob F P van den Akker, Ben J A Janssen, Jacques J Debets, Jo G R De Mey, Erik S G Stroes, Bert-Jan H van den Born, Dayanjan S Wijesinghe, Charles E Chalfant, Luke MacAleese, Gert B Eijkel, Ron M A Heeren, Astrid E Alewijnse, Stephan L M Peters
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21817 (2011)
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid biology is alte
Externí odkaz:
https://doaj.org/article/7ea95473f792457ab3148a3baa0d7cd5
Publikováno v:
British Journal of Pharmacology. 166:1411-1418
BACKGROUND AND PURPOSE FTY720 (Fingolimod) is a recently approved orally administered drug for the treatment of multiple sclerosis. Phase II and III clinical trials have demonstrated that this drug modestly increases BP. We previously showed that inh
Autor:
Marco Presta, Stefania Nicoli, Simone Buraschi, Chiara Tobia, Stefania Mitola, Patrizia Dell'Era, Paola Chiodelli, Pieter B. van Loenen, Efrem Foglia, Astrid E. Alewijnse
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, 32(9), E104-E116. Lippincott Williams and Wilkins
Objective— Endothelial sphingosine-1-phosphate (S1P) receptor-1 (S1P 1 ) affects different vascular functions, including blood vessel maturation and permeability. Here, we characterized the role of the zS1P 1 ortholog in vascular development in zeb
Autor:
Didier Rognan, Astrid E. Alewijnse, Dennis Verzijl, Stephan L. M. Peters, Rob Leurs, Pieter B. van Loenen, Chris de Graaf
Publikováno v:
European Journal of Pharmacology, 667(1-3), 105-12. Elsevier
van Loenen, P B, de Graaf, C, Verzijl, D, Leurs, R, Rognan, D, Peters, S L M & Alewijnse, A E 2011, ' Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor ', European Journal of Pharmacology, vol. 667, no. 1-3, pp. 105-12 . https://doi.org/10.1016/j.ejphar.2011.05.071
European journal of pharmacology, 667(1-3), 105-112. Elsevier
van Loenen, P B, de Graaf, C, Verzijl, D, Leurs, R, Rognan, D, Peters, S L M & Alewijnse, A E 2011, ' Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor ', European Journal of Pharmacology, vol. 667, no. 1-3, pp. 105-12 . https://doi.org/10.1016/j.ejphar.2011.05.071
European journal of pharmacology, 667(1-3), 105-112. Elsevier
The sphingosine-1-phosphate type 1 (S1P(1)) receptor is a new target in the treatment of auto-immune diseases as evidenced by the recent approval of FTY720 (Fingolimod). The ligand-binding pocket of the S1P(1) receptor has been generally characterise
Autor:
Astrid E. Alewijnse, Jack van Horssen, Kim Lakeman, Eric Ronken, Helga E. de Vries, Dennis Verzijl, Stephan L. M. Peters, Arie Reijerkerk, Christine D. Dijkstra, Bert van het Hof, Maarten E. Witte, Paul van der Valk, Ruben van Doorn
Publikováno v:
Glia. 58:1465-1476
Sphingolipids are a class of biologically active lipids that have a role in multiple biological processes including inflammation. Sphingolipids exert their functions by direct signaling or through signaling by their specific receptors. Phosphorylated
Autor:
Marcel M. G. J. van Borren, Jan G. Zegers, E. E. Verheijck, Jan Bourier, Astrid E. Alewijnse, Hanno L. Tan, Najat Hajji, Jan-Hindrik Ravesloot, Arie O. Verkerk, Stephan L. M. Peters, Ronald Wilders
Publikováno v:
Basic research in cardiology, 105(1), 73-87. D. Steinkopff-Verlag
Basic Research in Cardiology
Basic Research in Cardiology
We investigated the contribution of the intracellular calcium (Ca (i) (2+) ) transient to acetylcholine (ACh)-mediated reduction of pacemaker frequency and cAMP content in rabbit sinoatrial nodal (SAN) cells. Action potentials (whole cell perforated
Autor:
Stephan L. M. Peters, Martin C. Michel, J. van Unen, Astrid E. Alewijnse, Maikel Jongsma, P. B. Van Loenen
Publikováno v:
British Journal of Pharmacology. 156:1305-1311
Background and purpose: Recently, some ligands targeting the sphingosine-1-phosphate receptor subtype 3 (S1P 3 ) have become available. The characterization of these compounds was mainly based on one functional read-out system, although S1 P 3 recept
Autor:
Mariëlle C. Hendriks-Balk, Najat Hajji, Martin C. Michel, Stephan L. M. Peters, Pieter B. van Loenen, Astrid E. Alewijnse
Publikováno v:
European journal of pharmacology, 600(1-3), 1-9. Elsevier
Sphingosine-1-phosphate (S1P) signalling via G protein-coupled receptors is important for the regulation of cell function and differentiation. Specific Regulators of G protein Signalling (RGS) proteins modulate the function of these receptors in many