Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Astrid Drasche"'
Autor:
Georg Gruenbacher, Hubert Gander, Andrea Rahm, Gabriele Dobler, Astrid Drasche, Jakob Troppmair, Walter Nussbaumer, Martin Thurnher
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The G protein-coupled P2Y11 receptor is known to sense extracellular ATP during inflammatory and immune responses. The dinucleotide NAD+ has also been proposed to be a P2Y11 receptor ligand but its role is less clear. Here, we have examined for the f
Externí odkaz:
https://doaj.org/article/f7527065a0d64848875bd47014568c8c
Autor:
Bettina Zelger, Dolores Wolfram, Dietmar Öfner, Astrid Drasche, Nadine Eberhart, Dominik Moser, Jakob Troppmair, Theresa Hautz, Bernhard Zelger, Johanna Grahammer, Michael J.F. Blumer, Stefan Schneeberger
Publikováno v:
American Journal of Transplantation
Cytokine‐expression profiles revealed IL‐1ß highly upregulated in rejecting skin of limb allografts. We investigate the effect of intragraft treatment with a neutralizing IL‐1β antibody in limb transplantation. Following allogenic hind‐limb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdcc6c49f9b7cc7ab1e9261dccc5228
https://doi.org/10.1111/ajt.14765
https://doi.org/10.1111/ajt.14765
Autor:
Sana, Khalid, Astrid, Drasche, Marco, Thurner, Martin, Hermann, Muhammad Imtiaz, Ashraf, Friedrich, Fresser, Gottfried, Baier, Leopold, Kremser, Herbert, Lindner, Jakob, Troppmair
Publikováno v:
Scientific Reports
p66Shc-dependent ROS production contributes to many pathologies including ischemia/reperfusion injury (IRI) during solid organ transplantation. Inhibiting p66Shc activation may provide a novel therapeutic approach to prevent damage, which is poorly m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8673ab4c04f785eeb7f651db3088e2d8
Autor:
Martina, Haller, Sana, Khalid, Leopold, Kremser, Friedrich, Fresser, Tobias, Furlan, Martin, Hermann, Julia, Guenther, Astrid, Drasche, Michael, Leitges, Marco, Giorgio, Gottfried, Baier, Herbert, Lindner, Jakob, Troppmair
Publikováno v:
The Journal of Biological Chemistry
Dysfunctional mitochondria contribute to the development of many diseases and pathological conditions through the excessive production of reactive oxygen species (ROS), and, where studied, ablation of p66Shc (p66) was beneficial. p66 translocates to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d206a0ea7c78eb8608f43448b4940434
http://hdl.handle.net/11577/3339104
http://hdl.handle.net/11577/3339104
Autor:
Katarzyna, Koziel, Julija, Smigelskaite, Astrid, Drasche, Marion, Enthammer, Muhammad Imtiaz, Ashraf, Sana, Khalid, Jakob, Troppmair
Publikováno v:
Experimental Cell Research
We have shown previously that mitochondrial ROS production is essential to turn growth factor (GF) removal into cell death. Activated RAF, AKT, Bcl-2 and antioxidants protected equally well against ROS accumulation and subsequent death. Here we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ec662bce32143be15f8567bbe0dd085
https://pubmed.ncbi.nlm.nih.gov/23933517
https://pubmed.ncbi.nlm.nih.gov/23933517
Autor:
David Matallanas, Albert Wölfler, Claudia Bodner, Franz Quehenberger, Daniela Pirkebner, Heinz Sill, Armin Zebisch, O Wolf, Astrid Drasche, Jakob Troppmair, Karin Lind, Ruud Delwel, Martina Haller, Karen Blyth, Isabella Fried, Erdogan Taskesen, Oliver Rath, Walter Kolch
Publikováno v:
Leukemia, 26(8), 1842-1849. Nature Publishing Group
RAF kinase inhibitor protein (RKIP) is a negative regulator of the RAS-mitogen-activated protein kinase/extracellular signal-regulated kinase signaling cascade. We investigated its role in acute myeloid leukemia (AML), an aggressive malignancy arisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546846fa1f03e1271cba0aeaf6084532
https://pubmed.ncbi.nlm.nih.gov/22388727
https://pubmed.ncbi.nlm.nih.gov/22388727
Autor:
Juergen C. Becker, Roland Houben, Jakob Troppmair, Astrid Drasche, Marco J Herold, Sonja Ortmann
Publikováno v:
The Journal of investigative dermatology. 129(2)
Due to elaborate control mechanisms, in benign tumors the activation of oncogenes primarily induces senescence, associated with cessation of cellular proliferation; for example, melanocytic nevi expressing mutant B-Raf. These mechanisms include the R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f573bf915523689d9918fae02ed81a85
https://pubmed.ncbi.nlm.nih.gov/18650848
https://pubmed.ncbi.nlm.nih.gov/18650848
Autor:
Jakob Troppmair, Pamela Kogler, Martin Wurm, Astrid Drasche, Martin Hermann, Raimund Margreiter, Dietmar Öfner, Ingmar Königsrainer, Fritz H. Bach, Helmut Weiss, Albert Amberger, Robert Öllinger
Publikováno v:
Cell cycle (Georgetown, Tex.). 6(24)
Bilirubin for decades was considered a potentially toxic waste product of heme degradation until the discovery that it is a potent antioxidant. Accumulating data from observations in humans and experimental studies indicate that the bile pigment may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c814665c7348182d2b39462c5530064
https://pubmed.ncbi.nlm.nih.gov/18073533
https://pubmed.ncbi.nlm.nih.gov/18073533
Autor:
Gabriele Mörsdorf, Peter Klein-Weigel, Reinhold Perkmann, Astrid Drasche, Anton Klingler, H. G. Schwelberger, Josef Klocker, G. Fraedrich
Publikováno v:
Vascular pharmacology. 40(6)
Besides its anticoagulant activity, the sulfated polysaccharide heparin has numerous other biological effects. Especially the antiinflammatory and immunoregulatory properties of heparin may be associated with its ability to release the histamine-degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea76c17cb3ac73589057231644308ff
https://pubmed.ncbi.nlm.nih.gov/15063833
https://pubmed.ncbi.nlm.nih.gov/15063833
Autor:
Astrid Drasche, Walter Kolch, Franz Quehenberger, Claudia Bodner, Albert Woelfler, Heinz Sill, Martina Haller, Karin Hiden, Daniela Pirkebner, Erdogan Taskesen, Karen Blyth, Oliver Rath, Jakob Troppmair, Armin Zebisch
Publikováno v:
Blood. 116:4185-4185
Abstract 4185 RAF kinase inhibitor protein (RKIP) has been described as a negative regulator of the RAS-mitogen activated protein kinase (MAPK) signaling cascade and as a metastasis suppressor gene in solid tumors. As constitutive activation of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b930e9bc0c766f9cd7c9bb40a64657
https://doi.org/10.1182/blood.v116.21.4185.4185
https://doi.org/10.1182/blood.v116.21.4185.4185