Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Astrid D. Bakker"'
Autor:
Solen Novello, Ton Schoenmaker, Teun J. de Vries, Behrouz Zandieh Doulabi, Astrid D. Bakker, Marja L. Laine, Ineke D.C. Jansen
Publikováno v:
Bone Reports, Vol 22, Iss , Pp 101798- (2024)
In periodontitis, gingival fibroblasts (GF) appear to produce a multitude of paracrine factors. However, the influence of GF-derived soluble factors on osteoclastogenesis remains unclear. In this case study, production of paracrine factors by GF was
Externí odkaz:
https://doaj.org/article/35a6187bd3644276a5dd88494107e699
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Supraphysiological loading induced by unstable orthopedic implants initiates osteoclast formation, which results in bone degradation. We aimed to investigate which mechanosensitive cells in the peri-implant environment produce osteoclast-sti
Externí odkaz:
https://doaj.org/article/92cb8f09fe3e4768b762c63790c53b2b
Autor:
Victor J. B. van Santen, Behrouz Zandieh Doulabi, Cornelis M. Semeins, Jolanda M. A. Hogervorst, Cornelia Bratengeier, Astrid D. Bakker
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 759 (2023)
Once prostate cancer cells metastasize to bone, they perceive approximately 2 kPa compression. We hypothesize that 2 kPa compression stimulates the epithelial-to-mesenchymal transition (EMT) of prostate cancer cells and alters their production of par
Externí odkaz:
https://doaj.org/article/ee6e6620b2ed4a10ac6b706277169388
Autor:
Victor J. B. van Santen, Angela P. Bastidas Coral, Jolanda M. A. Hogervorst, Jenneke Klein-Nulend, Astrid D. Bakker
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 169 (2022)
Standard cell cultures may not predict the proliferation and differentiation potential of human mesenchymal stromal cells (MSCs) after seeding on a scaffold and implanting this construct in a bone defect. We aimed to develop a more biologically relev
Externí odkaz:
https://doaj.org/article/dfc7156461d847c5a77be622ec6f6347
Autor:
Jianfeng Jin, Richard T. Jaspers, Gang Wu, Joannes A.M. Korfage, Jenneke Klein-Nulend, Astrid D. Bakker
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8361 (2020)
Mechanical loading preserves bone mass and function—yet, little is known about the cell biological basis behind this preservation. For example, cell and nucleus morphology are critically important for cell function, but how these morphological char
Externí odkaz:
https://doaj.org/article/d1b3631c9bc94bce88df656ec0cca93c
Autor:
Cindy Kelder, Cornelis J. Kleverlaan, Marjolijn Gilijamse, Astrid D. Bakker, Teun J. de Vries
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 5072 (2020)
Osteoblasts derived from mouse skulls have increased osteoclastogenic potential compared to long bone osteoblasts when stimulated with 1,25(OH)2 vitamin D3 (vitD3). This indicates that bone cells from specific sites can react differently to biochemic
Externí odkaz:
https://doaj.org/article/ddf26d402ac74dabbfd01bf5a0dc2b0f
Autor:
Cindy Kelder, Jolanda M.A. Hogervorst, Daniël Wismeijer, Cornelis J. Kleverlaan, Teun J. de Vries, Astrid D. Bakker
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3202 (2020)
Incorporation of 1,25(OH)2 vitamin D3 (vitD3) into tissue-engineered scaffolds could aid the healing of critical-sized bone defects. We hypothesize that shorter applications of vitD3 lead to more osteogenic differentiation of mesenchymal stem cells (
Externí odkaz:
https://doaj.org/article/9e5846add9c5459e9c9e32d9283ce148
Autor:
Hessam Tabeian, Beatriz F. Betti, Cinthya dos Santos Cirqueira, Teun J. de Vries, Frank Lobbezoo, Anouk V. ter Linde, Behrouz Zandieh-Doulabi, Marije I. Koenders, Vincent Everts, Astrid D. Bakker
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2260 (2019)
The temporomandibular joint (TMJ), which differs anatomically and biochemically from hyaline cartilage-covered joints, is an under-recognized joint in arthritic disease, even though TMJ damage can have deleterious effects on physical appearance, pain
Externí odkaz:
https://doaj.org/article/44cb3a51f6444810946e66140b35ac97
Autor:
Angela P. Bastidas-Coral, Astrid D. Bakker, Behrouz Zandieh-Doulabi, Cornelis J. Kleverlaan, Nathalie Bravenboer, Tim Forouzanfar, Jenneke Klein-Nulend
Publikováno v:
Stem Cells International, Vol 2016 (2016)
During the initial stages of bone repair, proinflammatory cytokines are released within the injury site, quickly followed by a shift to anti-inflammatory cytokines. The effect of pro- and anti-inflammatory cytokines on osteogenic differentiation of m
Externí odkaz:
https://doaj.org/article/ad08bc2daa5b4aa4b3dcb6e693ed00c2
Publikováno v:
Biochemical and Biophysical Research Communications, 646, 70-77. Academic Press Inc.
van Santen, V J B, Jin, J, Hogervorst, J M A & Bakker, A D 2023, ' Shear loaded osteocyte-like-cells affect epithelial and mesenchymal gene expression in DU145 prostate cancer cells, while decreasing their invasion in vitro ', Biochemical and Biophysical Research Communications, vol. 646, pp. 70-77 . https://doi.org/10.1016/j.bbrc.2023.01.066
van Santen, V J B, Jin, J, Hogervorst, J M A & Bakker, A D 2023, ' Shear loaded osteocyte-like-cells affect epithelial and mesenchymal gene expression in DU145 prostate cancer cells, while decreasing their invasion in vitro ', Biochemical and Biophysical Research Communications, vol. 646, pp. 70-77 . https://doi.org/10.1016/j.bbrc.2023.01.066
Once prostate cancer (PC) metastasizes towards bone the 5-year survival rates drop with 70%, but it is largely unknown why. Bone is continuously mechanically loaded, which likely modulates the paracrine signaling from osteocytes towards PC cells to a