Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Astrid Dürauer"'
Autor:
Maria Toth, Manuel Reithofer, Gregory Dutra, Patricia Pereira Aguilar, Astrid Dürauer, Reingard Grabherr
Publikováno v:
Viruses, Vol 16, Iss 3, p 426 (2024)
(1) Recombinant protein production in mammalian cells is either based on transient transfection processes, often inefficient and underlying high batch-to-batch variability, or on laborious generation of stable cell lines. Alternatively, BacMam, a tra
Externí odkaz:
https://doaj.org/article/824026465af14447a8c9b3ea9ac786a0
Model-based real-time monitoring of biopharmaceutical production is a major step towards Quality-by-Design in this field and the fundament for model predictive control. Data-driven models have been proven a viable option to model bioprocesses. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46aa99e97acf75d65204b1a9c8890059
https://doi.org/10.22541/au.168396677.73335612/v1
https://doi.org/10.22541/au.168396677.73335612/v1
The biopharmaceutical industry is still running in batch mode, mostly because it is a highly regulated industry sector. In the past, sensors were not readily available and in-process control was mainly executed off-line. The most important product pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45ccc526e9740da70a05e292703a5509
https://doi.org/10.22541/au.167898784.45653707/v1
https://doi.org/10.22541/au.167898784.45653707/v1
Autor:
Anna Christler, Theresa Scharl, Michael Melcher, Johannes Köppl, Anne Tscheließnig, Cabir Toy, Astrid Dürauer, Alois Jungbauer, Dominik G. Sauer
Publikováno v:
Biotechnology and Bioengineering
Technological developments require the transfer to their location of application to make use of them. We describe the transfer of a real‐time monitoring system for lab‐scale preparative chromatography to two new sites where it will be used and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c01d3eeb848f75ef6fad5b05663b7c
http://europepmc.org/articles/PMC8518415
http://europepmc.org/articles/PMC8518415
Publikováno v:
Chemical Engineering and Processing - Process Intensification. 184:109303
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168101860620c56d71f0a3c85702515d
https://doi.org/10.1016/j.cep.2023.109303
https://doi.org/10.1016/j.cep.2023.109303
Autor:
Alois Jungbauer, Anna Christler, Astrid Dürauer, E. Felföldi, Dominik Georg Sauer, Magdalena Mosor, Nicole Walch
Publikováno v:
Bioprocess and Biosystems Engineering. 43:753-764
The aim of this study was to semi-automate process analytics for the quantification of common impurities in downstream processing such as host cell DNA, host cell proteins and endotoxins using a commercial liquid handling station. By semi-automation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29bd3ca283624b28fa8dae024af2cfff
https://doi.org/10.1007/s00449-019-02254-y
https://doi.org/10.1007/s00449-019-02254-y
Publikováno v:
Biotechnology and bioengineering. 119(2)
Parameter estimation for scale-up of downstream operations from microtiter plates (MTPs) is mostly done empirically because engineering correlations between microplates and stirred tank reactors (STRs) are not yet available. It is challenging to chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e398e7eb1d5798a16ee2620d2686e6
https://pubmed.ncbi.nlm.nih.gov/34741535
https://pubmed.ncbi.nlm.nih.gov/34741535
Autor:
Nicole Walch, Theresa Scharl-Hirsch, Dominik Georg Sauer, Magdalena Mosor, Friedrich Leisch, Astrid Dürauer, Alois Jungbauer, Michael Melcher, Matthias Berkemeyer
Publikováno v:
Biotechnology and Bioengineering
Process analytical technology combines understanding and control of the process with real‐time monitoring of critical quality and performance attributes. The goal is to ensure the quality of the final product. Currently, chromatographic processes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7effe83279dafe67c7c749939fd611c0
https://doi.org/10.1002/bit.26984
https://doi.org/10.1002/bit.26984
Publikováno v:
Journal of Chromatography A. 1676:463264
Elucidation of intraparticle mass transfer mechanisms in protein chromatography is essential for process design. This study investigates the differences of adsorption and diffusion parameters of basic human fibroblast factor 2 (hFGF2) in a simple (pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ce753333718e7985819d21657fb8cd
https://doi.org/10.1016/j.chroma.2022.463264
https://doi.org/10.1016/j.chroma.2022.463264
Publikováno v:
Processes
Volume 8
Issue 12
Processes, Vol 8, Iss 1625, p 1625 (2020)
Volume 8
Issue 12
Processes, Vol 8, Iss 1625, p 1625 (2020)
Ultrafiltration is a powerful method used in virtually every pharmaceutical bioprocess. Depending on the process stage, the product-to-impurity ratio differs. The impact of impurities on the process depends on various factors. Solely mechanistic mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ed6efe1ccee30deee1f0ce3dbe2a40