Association of Body Mass Index with Depression, Anxiety and Suicide-An Instrumental Variable Analysis of the HUNT Study.

Autor: Johan Håkon Bjørngaard, David Carslake, Tom Ivar Lund Nilsen, Astrid C E Linthorst, George Davey Smith, David Gunnell, Pål Richard Romundstad

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0131708 (2015)

OBJECTIVE:While high body mass index is associated with an increased risk of depression and anxiety, cumulative evidence indicates that it is a protective factor for suicide. The associations from conventional observational studies of body mass index

Externí odkaz: https://doaj.org/article/4b6dbc7bc8cb4e97a69719e6ecc163b1

Continuous Free Cortisol Profiles-Circadian Rhythms in Healthy Men

Autor: JA Leendertz, Viktoria J. Kluckner, Georgina M Russell, Hans H. Stassen, Ragini Bhake, Astrid C E Linthorst, Stafford L. Lightman, Kara Stevens

Publikováno v: Bhake, R C, Kluckner, V, Stassen, H, Russell, G M, Leendertz, J, Stevens, K, Linthorst, A C E & Lightman, S L 2019, ' Continuous Free Cortisol Profiles-Circadian Rhythms in Healthy Men ', Journal of Clinical Endocrinology and Metabolism, vol. 104, no. 12, pp. 5935-5947 . https://doi.org/10.1210/jc.2019-00449

ContextThe pituitary–adrenal axis had historically been considered a representative model for circadian rhythms. A recently developed portable collection device has provided the opportunity to evaluate free cortisol profiles using the microdialysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa40676972034ba7ef157bbeffb775b
https://pubmed.ncbi.nlm.nih.gov/31355884

Epigenetics of Glucocorticoid Action

Autor: Sylvia D. Carter, Karen R. Mifsud, Johannes M. H. M. Reul, Astrid C E Linthorst

Glucocorticoid hormones play a pivotal role in countless processes in the brain at the molecular, cellular, physiological, and behavioral level. In view of their widespread influence, a tight control of glucocorticoid action is of great importance. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4bcd26e4c388427f2ab0ca765f7147d
https://doi.org/10.1016/b978-0-12-803592-4.00046-8

A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus

Autor: Johannes M. H. M. Reul, Matthew C. Walker, Alexey Semyanov, Flavie Kersanté, Ivan Pavlov, Samuel C. S. Rowley, Maria Gutierrez-Mecinas, Astrid C E Linthorst

Publikováno v: The Journal of Physiology

Tonic γ-aminobutyric acid (GABA)A receptor-mediated signalling controls neuronal network excitability in the hippocampus. Although the extracellular concentration of GABA (e[GABA]) is critical in determining tonic conductances, knowledge on how e[GA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b39d4814d82cfad9aded97fe34604e
http://europepmc.org/articles/PMC3678035

Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain

Autor: Stafford L. Lightman, Johannes M. H. M. Reul, Susanne K. Droste, Xiaoxiao Qian, Astrid C E Linthorst

Publikováno v: Endocrinology
Qian, X, Droste, S K, Lightman, S L, Reul, J M H M & Linthorst, A C E 2012, ' Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain ', Endocrinology, vol. 153, no. 9, pp. 4346-4353 . https://doi.org/10.1210/en.2012-1484

Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of the glucocorticoid is bound to corticosteroid-binding globulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dde9f32b8bbbb0f5f878dd2f33aa85e
https://doi.org/10.1210/en.2012-1484