Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Astrid Breitbart"'
Autor:
Mirja Mittermaier, Philipp Pickerodt, Florian Kurth, Laure Bosquillon de Jarcy, Alexander Uhrig, Carmen Garcia, Felix Machleidt, Panagiotis Pergantis, Susanne Weber, Yaosi Li, Astrid Breitbart, Felix Bremer, Philipp Knape, Marc Dewey, Felix Doellinger, Steffen Weber-Carstens, Arthur S. Slutsky, Wolfgang M. Kuebler, Norbert Suttorp, Holger Müller-Redetzky
Publikováno v:
EClinicalMedicine, Vol 28, Iss , Pp 100579- (2020)
Background: In face of the Coronavirus Disease (COVID)-19 pandemic, best practice for mechanical ventilation in COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) is intensely debated. Specifically, the rationale for high positive end-exp
Externí odkaz:
https://doaj.org/article/12b67e81003f4397bc5d9223a0e6b112
Autor:
Astrid Breitbart, Gesine M Scharf, David Duncker, Christian Widera, Jens Gottlieb, Arndt Vogel, Sebastian Schmidt, Gudrun Brandes, Hans-Gert Heuft, Ralf Lichtinghagen, Tibor Kempf, Kai C Wollert, Johann Bauersachs, Joerg Heineke
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80454 (2013)
BACKGROUND: Myostatin is a muscle derived factor that functions as a negative regulator of skeletal muscle growth. Induction of myostatin expression was observed in rodent models of muscle wasting and in cachectic patients with cancer or pulmonary di
Externí odkaz:
https://doaj.org/article/912d68064ba24d4889b7961b4b6afdd7
Autor:
Vadim Demichev, Pinkus Tober-Lau, Oliver Lemke, Tatiana Nazarenko, Charlotte Thibeault, Harry Whitwell, Annika Röhl, Anja Freiwald, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Simran Kaur Aulakh, Elisa T. Helbig, Paula Stubbemann, Lena J. Lippert, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B. Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J. Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Mirja Mittermaier, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S. Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Philipp Enghard, Aleksej Zelezniak, Archie Campbell, Caroline Hayward, David J. Porteous, Riccardo E. Marioni, Alexander Uhrig, Holger Müller-Redetzky, Heinz Zoller, Judith Löffler-Ragg, Markus A. Keller, Ivan Tancevski, John F. Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, Markus Ralser, Florian Kurth, Malte Kleinschmidt, Katrin M. Heim, Belén Millet, Lil Meyer-Arndt, Ralf H. Hübner, Tim Andermann, Jan M. Doehn, Bastian Opitz, Birgit Sawitzki, Daniel Grund, Peter Radünzel, Mariana Schürmann, Thomas Zoller, Florian Alius, Philipp Knape, Astrid Breitbart, Yaosi Li, Felix Bremer, Panagiotis Pergantis, Dirk Schürmann, Bettina Temmesfeld-Wollbrück, Daniel Wendisch, Sophia Brumhard, Sascha S. Haenel, Claudia Conrad, Philipp Georg, Kai-Uwe Eckardt, Lukas Lehner, Jan M. Kruse, Carolin Ferse, Roland Körner, Claudia Spies, Andreas Edel, Steffen Weber-Carstens, Alexander Krannich, Saskia Zvorc, Linna Li, Uwe Behrens, Sein Schmidt, Maria Rönnefarth, Chantip Dang-Heine, Robert Röhle, Emma Lieker, Lucie Kretzler, Isabelle Wirsching, Christian Wollboldt, Yinan Wu, Georg Schwanitz, David Hillus, Stefanie Kasper, Nadine Olk, Alexandra Horn, Dana Briesemeister, Denise Treue, Michael Hummel, Victor M. Corman, Christian Drosten, Christof von Kalle
Publikováno v:
794.e7
Cell Systems
Cell Systems
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9926f617619421e736ef19e24395fb
Autor:
Hans Reinecke, Deok Ho Kim, Lil Pabon, Joy Xu, Kai Chun Yang, Akiko Futakuchi-Tsuchida, Michael Regnier, Maria V. Razumova, Peter Hofsteen, Charles E. Murry, J. Carter Ralphe, Cody Schopf, Alex Jiao, Astrid Breitbart, Robert J. Boucek, Willem J. de Lange
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 728-740 (2018)
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 728-740 (2018)
Visual Abstract
Highlights • Many cardiomyopathy families have genetic variants whose significance is unknown. We studied a novel (E848G) mutation in MYH7, a sarcomeric protein. • Patient-specific induced pluripotent stem cell–derived card
Highlights • Many cardiomyopathy families have genetic variants whose significance is unknown. We studied a novel (E848G) mutation in MYH7, a sarcomeric protein. • Patient-specific induced pluripotent stem cell–derived card
Autor:
Mirja Mittermaier, Philipp Pickerodt, Florian Kurth, Laure Bosquillon de Jarcy, Leif Erik Sander, Alexander Uhrig, Carmen Garcia, Felix Machleidt, Panagiotis Pergantis, Susanne Weber, Yaosi Li, Astrid Breitbart, Felix Bremer, Philipp Knape, Marc Dewey, Felix Döllinger, Steffen Weber-Carstens, Arthur S Slutsky, Wolfgang Kuebler, Norbert Suttorp, Martin Witzenrath, Holger Müller-Redetzky
Publikováno v:
SSRN Electronic Journal.
Background: In face of the global spread of Corona Virus Disease (COVID)-19, best practice for mechanical ventilation in COVID-19 associated Acute Respiratory
Autor:
G. William Wong, Hugo A. Katus, Oliver J. Müller, Daniela Fraccarollo, Andrea Grund, Astrid Breitbart, Joerg Heineke, Johann Bauersachs, Mona Malek Mohammadi, Kai C. Wollert, Florian Brandes, Mortimer Korf-Klingebiel, Mahesh Appari, Honghui Wang, Carolin Zwadlo, Natali Froese, Mona Nemer, Malgorzata Szaroszyk, Gesine M. Scharf, Ulrike Schrameck
Publikováno v:
Circulation Research. 120:66-77
Rationale: Myocardial endothelial cells promote cardiomyocyte hypertrophy, possibly through the release of growth factors. The identity of these factors, however, remains largely unknown, and we hypothesized here that the secreted CTRP9 (C1q-tumor ne
Autor:
Astrid Breitbart, Charles E. Murry
Publikováno v:
Cell stem cell. 18(4)
Mutations in DMD disrupt the reading frame, prevent dystrophin translation, and cause Duchenne muscular dystrophy (DMD). Here we describe a CRISPR/Cas9 platform applicable to 60% of DMD patient mutations. We applied the platform to DMD-derived hiPSCs
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 300:H1973-H1982
A significant proportion of heart failure patients develop skeletal muscle wasting and cardiac cachexia, which is associated with a very poor prognosis. Recently, myostatin, a cytokine from the transforming growth factor-β (TGF-β) family and a know
Autor:
Frank M. Bengel, David Duncker, Thorben König, Cathleen Haense, Carolin Zwadlo, Marcus Krüger, Johann Bauersachs, Georg Berding, Bernhard Schieffer, Astrid Breitbart, Gernot Beutel
Publikováno v:
Circulation. Cardiovascular imaging. 6(6)
An 88-year-old woman required out-of-hospital cardiopulmonary resuscitation (return of spontaneous circulation 2 minutes) for third-degree heart block and was admitted to our intensive care unit. The patient underwent urgent implantation of a dual-ch
Autor:
Johann Bauersachs, Ulrike Schrameck, Kai C. Wollert, Mortimer Korf-Klingebiel, Natali Froese, Florian Brandes, Jörg Heineke, Astrid Breitbart, Oliver J. Müller
Publikováno v:
Circulation Research. 113
Background: CTRP9 (also called C1qtnf9) is a newly discovered secreted protein and a paralog of adiponectin. The biological functions of CTRP9, however, are still largely unknown. Results: Although previous data from a semi-quantitative real-time PCR