Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells

Autor: Kai-Chun Yang, MD, Astrid Breitbart, MD, Willem J. De Lange, PhD, Peter Hofsteen, PhD, Akiko Futakuchi-Tsuchida, BS, Joy Xu, MSE, Cody Schopf, BS, Maria V. Razumova, PhD, Alex Jiao, PhD, Robert Boucek, MD, Lil Pabon, PhD, Hans Reinecke, PhD, Deok-Ho Kim, PhD, J. Carter Ralphe, MD, Michael Regnier, PhD, Charles E. Murry, MD, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 728-740 (2018)

Summary: A novel myosin heavy chain 7 mutation (E848G) identified in a familial cardiomyopathy was studied in patient-specific induced pluripotent stem cell–derived cardiomyocytes. The cardiomyopathic human induced pluripotent stem cell–derived c

Externí odkaz: https://doaj.org/article/55e66573abed49ff8e6ea65cc4f0d1b0

A time-resolved proteomic and prognostic map of COVID-19

Autor: Vadim Demichev, Pinkus Tober-Lau, Oliver Lemke, Tatiana Nazarenko, Charlotte Thibeault, Harry Whitwell, Annika Röhl, Anja Freiwald, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Simran Kaur Aulakh, Elisa T. Helbig, Paula Stubbemann, Lena J. Lippert, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B. Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J. Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Mirja Mittermaier, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S. Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Philipp Enghard, Aleksej Zelezniak, Archie Campbell, Caroline Hayward, David J. Porteous, Riccardo E. Marioni, Alexander Uhrig, Holger Müller-Redetzky, Heinz Zoller, Judith Löffler-Ragg, Markus A. Keller, Ivan Tancevski, John F. Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, Markus Ralser, Florian Kurth, Malte Kleinschmidt, Katrin M. Heim, Belén Millet, Lil Meyer-Arndt, Ralf H. Hübner, Tim Andermann, Jan M. Doehn, Bastian Opitz, Birgit Sawitzki, Daniel Grund, Peter Radünzel, Mariana Schürmann, Thomas Zoller, Florian Alius, Philipp Knape, Astrid Breitbart, Yaosi Li, Felix Bremer, Panagiotis Pergantis, Dirk Schürmann, Bettina Temmesfeld-Wollbrück, Daniel Wendisch, Sophia Brumhard, Sascha S. Haenel, Claudia Conrad, Philipp Georg, Kai-Uwe Eckardt, Lukas Lehner, Jan M. Kruse, Carolin Ferse, Roland Körner, Claudia Spies, Andreas Edel, Steffen Weber-Carstens, Alexander Krannich, Saskia Zvorc, Linna Li, Uwe Behrens, Sein Schmidt, Maria Rönnefarth, Chantip Dang-Heine, Robert Röhle, Emma Lieker, Lucie Kretzler, Isabelle Wirsching, Christian Wollboldt, Yinan Wu, Georg Schwanitz, David Hillus, Stefanie Kasper, Nadine Olk, Alexandra Horn, Dana Briesemeister, Denise Treue, Michael Hummel, Victor M. Corman, Christian Drosten, Christof von Kalle

Publikováno v: 794.e7
Cell Systems

COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9926f617619421e736ef19e24395fb

Highly specific detection of myostatin prodomain by an immunoradiometric sandwich assay in serum of healthy individuals and patients.

Autor: Astrid Breitbart, Gesine M Scharf, David Duncker, Christian Widera, Jens Gottlieb, Arndt Vogel, Sebastian Schmidt, Gudrun Brandes, Hans-Gert Heuft, Ralf Lichtinghagen, Tibor Kempf, Kai C Wollert, Johann Bauersachs, Joerg Heineke

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80454 (2013)

BACKGROUND: Myostatin is a muscle derived factor that functions as a negative regulator of skeletal muscle growth. Induction of myostatin expression was observed in rodent models of muscle wasting and in cachectic patients with cancer or pulmonary di

Externí odkaz: https://doaj.org/article/912d68064ba24d4889b7961b4b6afdd7

C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure

Autor: G. William Wong, Hugo A. Katus, Oliver J. Müller, Daniela Fraccarollo, Andrea Grund, Astrid Breitbart, Joerg Heineke, Johann Bauersachs, Mona Malek Mohammadi, Kai C. Wollert, Florian Brandes, Mortimer Korf-Klingebiel, Mahesh Appari, Honghui Wang, Carolin Zwadlo, Natali Froese, Mona Nemer, Malgorzata Szaroszyk, Gesine M. Scharf, Ulrike Schrameck

Publikováno v: Circulation Research. 120:66-77

Rationale: Myocardial endothelial cells promote cardiomyocyte hypertrophy, possibly through the release of growth factors. The identity of these factors, however, remains largely unknown, and we hypothesized here that the secreted CTRP9 (C1q-tumor ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9992fce5c21fe5f8a669eb700900225
https://doi.org/10.1161/circresaha.116.309398

Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting

Autor: Joerg Heineke, Astrid Breitbart, Mannix Auger-Messier, Jeffery D. Molkentin

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 300:H1973-H1982

A significant proportion of heart failure patients develop skeletal muscle wasting and cardiac cachexia, which is associated with a very poor prognosis. Recently, myostatin, a cytokine from the transforming growth factor-β (TGF-β) family and a know

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2acd902713cf2f0b41526b8abe76616
https://doi.org/10.1152/ajpheart.00200.2011