Výsledky vyhledávání - "Astrid Alonso Guerrero"

DIDO3 Regulates Microtubule Stability at Transcriptional and Posttranslational Levels and is Needed for Fibroblast Adhesion and Movement

Autor: Karel H. M. van Wely, Julio Gutiérrez, Ricardo Villares, Pablo Manrique, Yolanda R. Carrasco, Cristina Pacios-Bras, Astrid Alonso-Guerrero, Fernando Gutiérrez del Burgo, Carmen Mora Gallardo, Tirso Pons, Sara Roman-Garcia, Carlos Martínez-A

Publikováno v: SSRN Electronic Journal.

Microtubule (MT) dynamics are central to eukaryotic cell organization, intracellular transport, division, adhesion, polarization, and migration. Unbalanced MT stability is associated with metastasis and neurodegenerative diseases. We show that altere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41118c2ad1d127d3fbba60599f7aff55
https://doi.org/10.2139/ssrn.3428482

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Dido3-dependent HDAC6 targeting controls cilium size

Autor: Ainhoa Sánchez de Diego, Karel H. M. van Wely, Astrid Alonso Guerrero, Carlos Martínez-A

Publikováno v: Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
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En la superficie de muchos tipos de células los mamíferos podemos encontrar cilios, los cuales participan en multitud de procesos fisiológicos que van desde el crecimiento celular y el desarrollo hasta la percepción del ambiente en el que se encu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213e7362762209e62c6b5a1e78ba1c01
http://europepmc.org/articles/PMC3973121

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Merotelic attachments and non-homologous end joining are the basis of chromosomal instability

Autor: Astrid Alonso Guerrero, Carlos Martínez-A, Karel H. M. van Wely

Publikováno v: Cell Division
Cell Division, Vol 5, Iss 1, p 13 (2010)
Digital.CSIC. Repositorio Institucional del CSIC
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Although the large majority of solid tumors show a combination of mitotic spindle defects and chromosomal instability, little is known about the mechanisms that govern the initial steps in tumorigenesis. The recent report of spindle-induced DNA damag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe581a0e0e90a4cce7bcef37432e30c
https://pubmed.ncbi.nlm.nih.gov/20478024

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Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

Autor: Varvara Trachana, Carlos Martínez-A, Karel H. M. van Wely, Juan C. Cigudosa, Cristina Pacios-Bras, Nuria Panadero Díaz-Concha, Mercedes Cano Gamero, Agnes Fütterer, Astrid Alonso Guerrero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Most carcinomas present some form of chromosome instability in combination with spindle defects. Numerical instability is likely caused by spindle aberrations, but the origin of breaks and translocations remains elusive. To determine whether one mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a43cd80777f09b1517fafed1d09b79
https://europepmc.org/articles/PMC2840104/

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Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis

Autor: Ignacio Prieto, Mercedes Cano Gamero, Varvara Trachana, Fernando Roncal, Malcolm Buckle, Cristina Pacios-Bras, José Luis Barbero, Anna Kouznetsova, Mónica García-Gallo, Leonor Kremer, Hervé Leh, Astrid Alonso Guerrero, Karel H. M. van Wely, Juan Pablo Albar, Antonio Serrano, Carlos Martínez-A, Agnes Fütterer, Esther Leonardo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Synapsis of homologous chromosomes is a key meiotic event, mediated by a large proteinaceous structure termed the synaptonemal complex. Here we describe a role in meiosis for the murine Death inducer obliterator (Dido) gene. The Dido gene codes for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7355b25550ec2565a27eff0b591be36
http://hdl.handle.net/10261/16566

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Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability

Autor: Varvara Trachana, Agnes Fütterer, Karel H. M. van Wely, Astrid Alonso Guerrero, Carlos Martínez-A

Numerical and/or structural centrosome abnormalities have been correlated with most solid tumors and hematological malignancies. Tumorigenesis also is linked to defects in the mitotic or spindle assembly checkpoint, a key control mechanism that ensur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83624907cbaaf1f11f3cc2b42c287c42
https://europepmc.org/articles/PMC1815243/

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