Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Astrid A. Reus"'
Autor:
V. Blatz, Frank Henkler, Kerstin Reisinger, Stefan Pfuhler, Astrid A. Reus, Anja Fischer, Cyrille Krul, Sebastian Hoffmann, Thomas R. Downs, Manfred Liebsch, Markus Schulz, Joep Brinkmann, Andreas Luch, Ralph Pirow
Publikováno v:
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 827, 27-41
Recently revised OECD Testing Guidelines highlight the importance of considering the first site-of-contact when investigating the genotoxic hazard. Thus far, only in vivo approaches are available to address the dermal route of exposure. The 3D Skin C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b28f110d466e7f79407b358511cdc1c
http://resolver.tudelft.nl/uuid:153766fa-4050-432f-bb78-384547d26059
http://resolver.tudelft.nl/uuid:153766fa-4050-432f-bb78-384547d26059
Autor:
Astrid A. Reus, Annemieke Kolkman, Margaretha M.E. van der Kooi, Erik Emke, Sander C. van der Linden, Minne B. Heringa, Patrick S. Bäuerlein, Walter Brand, René H. van Doorn, Merijn Schriks, Pim de Voogt
Publikováno v:
Environmental toxicology and pharmacology, 36(3), 1291-1303. Elsevier
The combination of in vitro bioassays and chemical screening can provide a powerful toolbox to determine biologically relevant compounds in water extracts. In this study, a sample preparation method is evaluated for the suitability for both chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa631beed13009caca8bc19c654be46
https://doi.org/10.1016/j.etap.2013.10.009
https://doi.org/10.1016/j.etap.2013.10.009
Publikováno v:
Toxicology and Applied Pharmacology. 261:154-163
As a result of the chemical legislation concerning the registration, evaluation, authorization and restriction of chemicals (REACH), and the Seventh Amendment to the Cosmetics Directive, which prohibits animal testing in Europe for cosmetics, alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e7fb01eeda9fa9fa968f81d4321c97
https://doi.org/10.1016/j.taap.2012.03.019
https://doi.org/10.1016/j.taap.2012.03.019
Autor:
Astrid A. Reus, Sharon Robinson, Ingrid Pruimboom-Brees, Anthony M. Lynch, Richard N. C. van Meeuwen, Mustafa Usta, Wilfred J. M. Maas, Cyrille Krul, Peter Clements, Julia Kenny
Publikováno v:
Mutagenesis. 25:407-416
For pharmaceuticals, current regulatory guidance for photosafety testing states that studies are warranted for drug candidates that both absorb light in the range of 290-700 nm and that are either applied topically or reach the skin or eyes by system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbd4676fc610926496e7b9577792181
https://doi.org/10.1093/mutage/geq023
https://doi.org/10.1093/mutage/geq023
Autor:
Frederique van Acker, Mariëlle E.L. Wouters, C. Frieke Kuper, Ingeborg M. Kooter, Sabina Bijlsma, Mariska Gröllers-Mulderij, Esther K. Zondervan-van den Beuken, Astrid A. Reus, Nicole M.M. Meulendijks, Thérèse V. P. Maarschalkerweerd
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 29(2)
We investigated the toxicity of aggregated nanoparticles of cerium oxide (CeO2) using an in vitro 3D human bronchial epithelial model that included a mucociliary apparatus (MucilAir™). CeO2 was dispersed in saline and applied to the apical surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb52d37c0dd3a9abec71a02a29aaaf3
https://pubmed.ncbi.nlm.nih.gov/25448805
https://pubmed.ncbi.nlm.nih.gov/25448805
Autor:
Astrid A. Reus, Henk Van Loveren, Janine Ezendam, Jochem W. van der Veen, Wilfred J. M. Maas, Henny Hodemaekers
Publikováno v:
Toxicology in Vitro, 29(1), 81-84. Elsevier Science
The skin sensitizing potential of chemicals is mainly assessed using animal methods, such as the murine local lymph node assay. Recently, an in vitro assay based on a gene expression signature in the HaCaT keratinocyte cell line was proposed as an al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8969adcfa7bb6d1bd8c561dd3324a6f8
https://pubmed.ncbi.nlm.nih.gov/25236440
https://pubmed.ncbi.nlm.nih.gov/25236440
Autor:
Andreas Zeller, Stefan Pfuhler, Gregory J. Carr, Raffaella Corvi, Thomas R. Downs, Kerstin Reisinger, Astrid A. Reus, Cyrille Krul
Publikováno v:
Mutagenesis
Reconstructed 3D human epidermal skin models are increasingly being used for safety testing of chemicals. Based on EpiDerm™ tissues, an assay was developed in which the tissues were topically exposed to test chemicals for 3h followed by cell isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09e47303ffe30f4e8a6d6caa6929328
https://pubmed.ncbi.nlm.nih.gov/24150594
https://pubmed.ncbi.nlm.nih.gov/24150594
Autor:
C. Frieke Kuper, Astrid A. Reus, Harm T. Jansen, Jos van Triel, Yvonne C.M. Staal, Wilfred J. M. Maas, Samuel Constant
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 28(2)
The respiratory route is an important portal for human exposure to a large variety of substances. Consequently, there is an urgent need for realistic in vitro strategies for evaluation of the absorption of airborne substances with regard to safety an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb4603a5f6cc52b0d999a73ef2fd19a
https://pubmed.ncbi.nlm.nih.gov/24216300
https://pubmed.ncbi.nlm.nih.gov/24216300
Autor:
Peter Clements, Ingrid Pruimboom-Brees, Julia Kenny, Cyrille Krul, Mustafa Usta, Mike Aylott, Anthony M. Lynch, Astrid A. Reus
Publikováno v:
Mutagenesis. 27(6)
An in vivo photomicronucleus test (MNT) using rat skin, the target organ for photoirritancy and carcinogenicity, was recently described. The assay was evaluated using fluoroquinolone (FQ) antibiotics with varying degrees of phototoxic potency (i.e. s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592a93d78fc4c169618eb53feec326be
https://pubmed.ncbi.nlm.nih.gov/22935223
https://pubmed.ncbi.nlm.nih.gov/22935223
Publikováno v:
Mutagenesis. 26(2)
Photosafety testing is of concern for the evaluation of personal care products and pharmaceuticals. Current regulatory guidance state that photosafety should be evaluated for compounds that absorb radiation between 290 and 700 nm with relevant exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a712a2f1b3dad1412287a0013963fe02
https://pubmed.ncbi.nlm.nih.gov/20861153
https://pubmed.ncbi.nlm.nih.gov/20861153