Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Astrid Katzer"'
Autor:
Cholpon S. Djuzenova, Thomas Fischer, Astrid Katzer, Dmitri Sisario, Tessa Korsa, Gudrun Steussloff, Vladimir L. Sukhorukov, Michael Flentje
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-20 (2021)
Abstract Background Radiotherapy is routinely used to combat glioblastoma (GBM). However, the treatment efficacy is often limited by the radioresistance of GBM cells. Methods Two GBM lines MO59K and MO59J, differing in intrinsic radiosensitivity and
Externí odkaz:
https://doaj.org/article/375fc4254eaa473e9b05d8942717fc41
Autor:
Cholpon S. Djuzenova, Vanessa Fiedler, Simon Memmel, Astrid Katzer, Dmitri Sisario, Philippa K. Brosch, Alexander Göhrung, Svenja Frister, Heiko Zimmermann, Michael Flentje, Vladimir L. Sukhorukov
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-18 (2019)
Abstract Background Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, we explore the impact
Externí odkaz:
https://doaj.org/article/7e4c68ffa40347c499cac312a6147789
Autor:
Simon Memmel, Vladimir L Sukhorukov, Marcus Höring, Katherine Westerling, Vanessa Fiedler, Astrid Katzer, Georg Krohne, Michael Flentje, Cholpon S Djuzenova
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87052 (2014)
Glioblastoma multiforme (GBM) is characterized by rapid growth, invasion and resistance to chemo-/radiotherapy. The complex cell surface morphology with abundant membrane folds, microvilli, filopodia and other membrane extensions is believed to contr
Externí odkaz:
https://doaj.org/article/099af2c5c77f41fc9045b66e5e75c5e7
Autor:
Michael Flentje, Tessa Korsa, Astrid Katzer, Cholpon S. Djuzenova, Gudrun Steussloff, Thomas Fischer, Vladimir L. Sukhorukov, Dmitri Sisario
Publikováno v:
BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-20 (2021)
BMC Cancer, Vol 21, Iss 1, Pp 1-20 (2021)
Background Radiotherapy is routinely used to combat glioblastoma (GBM). However, the treatment efficacy is often limited by the radioresistance of GBM cells. Methods Two GBM lines MO59K and MO59J, differing in intrinsic radiosensitivity and mutationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd16bf2e9a392c892ebb80a43f64ffa
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/26582
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/26582
Autor:
Tessa Korsa, Gudrun Steussloff, Cholpon S. Djuzenova, Michael Flentje, Dmitri Sisario, Astrid Katzer, Vladimir L. Sukhorukov, Thomas Fischer
Background: Radiotherapy is routinely used to combat glioblastoma multiforme (GBM). However, the treatment efficacy is often limited by the radioresistance of GBM cells.Methods: Two isogenic GBM lines MO59K and MO59J, differing in intrinsic radiosens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14d63d8fa9e673bbe3382f8962cd5f49
https://doi.org/10.21203/rs.3.rs-121097/v1
https://doi.org/10.21203/rs.3.rs-121097/v1
Autor:
Heiko Zimmermann, Simon Memmel, Astrid Katzer, Lorenz Eing, Markus Sauer, Fábio Luiz Rogé Ferreira, Vanessa Fiedler, Dmitri Sisario, Caren Zöller, Robin Heiden, Cholpon S. Djuzenova, Vladimir L. Sukhorukov, Nicholas Becker, Michael Flentje
Publikováno v:
Oncotarget
// Simon Memmel 1 , Dmitri Sisario 1, 2 , Caren Zoller 1 , Vanessa Fiedler 1 , Astrid Katzer 1 , Robin Heiden 1 , Nicholas Becker 1 , Lorenz Eing 2 , Fabio L.R. Ferreira 1 , Heiko Zimmermann 3, 4 , Markus Sauer 2 , Michael Flentje 1 , Vladimir L. Suk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69deb0947bb43be0b5692ea25aecc811
https://doi.org/10.18632/oncotarget.16847
https://doi.org/10.18632/oncotarget.16847
Autor:
Cholpon S. Djuzenova, Simon Memmel, Dmitri Sisario, Michael Flentje, Vladimir L. Sukhorukov, Astrid Katzer, Felix Grabenbauer
Publikováno v:
Oncotarget
Targeting MEK protein in cancer cells usually leads to acquired resistance to MEK inhibitors and activation of the prosurvival protein Akt. Since both MEK and Akt are clients of the Hsp90 chaperone system, the present study explores the responses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354ea3c4bbfdcd90964b8bb99560733a
https://pubmed.ncbi.nlm.nih.gov/30647839
https://pubmed.ncbi.nlm.nih.gov/30647839
Autor:
Adrian Staab, Claudiu T. Supuran, Carsten Hagemann, Michael Flentje, Jelena Anacker, Andrea Scozzafava, Bülent Polat, Fabrizio Carta, Harun M. Said, Giles H. Vince, Astrid Katzer
Publikováno v:
Bioorganic & Medicinal Chemistry; Vol 21
Bioorganic & Medicinal Chemistry
Bioorganic & Medicinal Chemistry
HIF-1α regulated genes are mainly responsible for tumour resistance to radiation- and chemo-therapy. Among these genes, carbonic anhydrase isoform IX (CA9) is highly over expressed in many types of cancer especially in high grade brain cancer like G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b937e070b3cde2d22753d09f8aa925
Autor:
Mario Löhr, Michael Flentje, Astrid Katzer, Ralf-Ingo Ernestus, Harun M. Said, Roghaiyeh Safari, Ghada Al-Kafaji, Carsten Hagemann
Publikováno v:
Oncology reports. 37(6)
N-myc downstream-regulated gene 1 (NDRG1) is a tumor suppressor with the potential to suppress metastasis, invasion and migration of cancer cells. It is regulated under stress conditions such as starvation or hypoxia. NDRG1 regulation is both induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7121711a6179fa11aebba37a5816e19
https://pubmed.ncbi.nlm.nih.gov/28498432
https://pubmed.ncbi.nlm.nih.gov/28498432
Autor:
Vanessa Fiedler, Cholpon S. Djuzenova, Heiko Zimmermann, Vladimir L. Sukhorukov, Michael Flentje, Stefanie Deckert, Astrid Katzer, Konstanze Michel
Publikováno v:
Oncotarget
Inhibition of Hsp90 can increase the radiosensitivity of tumor cells. However, inhibition of Hsp90 alone induces the anti-apoptotic Hsp70 and thereby decreases radiosensitivity. Therefore, preventing Hsp70 induction can be a promising strategy for ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b347ee27124b20f6ca9bac91b8132f
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17777
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17777