Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Astrid, Zahn"'
Autor:
Dominic Dolbec, Mélanie Lehoux, Alexis Asselin de Beauville, Astrid Zahn, Javier Marcelo Di Noia, Mariela Segura
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011957 (2024)
Streptococcus suis serotype 2 is an important encapsulated bacterial swine pathogen and zoonotic agent for which no effective vaccine exists. The interaction with B cells and the humoral response against S. suis are poorly understood despite their li
Externí odkaz:
https://doaj.org/article/99c5b596395044f29bf8543cd7e4f135
Autor:
Félix Lombard-Vadnais, Geneviève Chabot-Roy, Astrid Zahn, Sahily Rodriguez Torres, Javier M. Di Noia, Heather J. Melichar, Sylvie Lesage
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105852- (2023)
Summary: Elimination of self-reactive T cells in the thymus is critical to establish T-cell tolerance. A growing body of evidence suggests a role for thymic B cells in the elimination of self-reactive thymocytes. To specifically address the role of t
Externí odkaz:
https://doaj.org/article/9b81a4e25aaf4411bb07d99e56fa8083
Autor:
Ludivine C. Litzler, Astrid Zahn, Alexandre P. Meli, Steven Hébert, Anne-Marie Patenaude, Stephen P. Methot, Adrien Sprumont, Thérence Bois, Daisuke Kitamura, Santiago Costantino, Irah L. King, Claudia L. Kleinman, Stéphane Richard, Javier M. Di Noia
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells,
Externí odkaz:
https://doaj.org/article/33da862d42ce48bf82823c6742c63b37
Publikováno v:
Bio-Protocol, Vol 6, Iss 3 (2016)
The enzyme Activation induced deaminase (AID) underpins antibody affinity maturation and isotype switching through its mutagenic activity of deaminating deoxycytidine to deoxyuridine in DNA. Subsequent processing of the deoxyuridine initiates the pro
Externí odkaz:
https://doaj.org/article/527c5c94b3e64cfc9d4041033880ea98
Autor:
Santiago Bertotti, Ian Fleming, María de los Milagros Cámara, Camila Centeno Cameán, Santiago J. Carmona, Fernán Agüero, Virginia Balouz, Astrid Zahn, Javier M. Di Noia, Juan D. Alfonzo, Carlos A. Buscaglia
Publikováno v:
The Biochemical journal. 479(4)
Adenosine-to-inosine conversion at position 34 (A34-to-I) of certain tRNAs is essential for expanding their decoding capacity. This reaction is catalyzed by the adenosine deaminase acting on tRNA (ADAT) complex, which in Eukarya is formed by two subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc66a682baa0ba549a1bfe9a38aa6ecc
https://pubmed.ncbi.nlm.nih.gov/35136964
https://pubmed.ncbi.nlm.nih.gov/35136964
Autor:
Jin Qian, Lingli Dong, Astrid Zahn, André Veillette, Irah L. King, Danielle Karo-Atar, Yan Lu, Javier M. Di Noia, Yingzi Zhu, Ming-Chao Zhong
Publikováno v:
The Journal of Experimental Medicine
SLAM family receptors are involved in humoral immune regulation. In this issue of JEM, Zhong et al. provide evidence that these receptors collectively suppress germinal center reaction but promote production of antigen-specific antibodies.
SLAM
SLAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3770062376150f5aef193e28f789024b
https://pubmed.ncbi.nlm.nih.gov/33570568
https://pubmed.ncbi.nlm.nih.gov/33570568
Autor:
Joseph A. Reed, Francisco Vega, Astrid Zahn, Javier M. Di Noia, Elena M. Cortizas, Ramiro E. Verdun, Shiva Safavi
Publikováno v:
The Journal of Experimental Medicine
Verdun and colleagues find that the uracil-DNA glycosylase UNG, which promotes DNA breaks in the immunoglobulin genes during class switch recombination and is required for AID-induced chromosomal translocations, protects telomeres from AID-induced DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9963f184e6c9c334a128325ffa1fc5e8
http://europepmc.org/articles/PMC5068241
http://europepmc.org/articles/PMC5068241
Autor:
Adrien Sprumont, Ludivine C. Litzler, Santiago Costantino, Therence Bois, Anne-Marie Patenaude, Claudia L. Kleinman, Alexandre P. Meli, Irah L. King, Javier M. Di Noia, Astrid Zahn, Daisuke Kitamura, Steven Hébert, Stephen P. Methot, Stéphane Richard
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein arginine methyltransferase 5 (Prmt5), which catalyzes most symmetric dimethyl arginine prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2288713c9188419b11e48c53132262f9
https://pubmed.ncbi.nlm.nih.gov/30604754
https://pubmed.ncbi.nlm.nih.gov/30604754
Autor:
Shiva Safavi, Damien Montamat-Sicotte, Markus Müschen, Denise P. Muñoz, Alexandre Orthwein, Astrid Zahn, Javier M. Di Noia, Pablo Oppezzo, Cecilia Abreu, Ludivine C. Litzler
Publikováno v:
European Journal of Immunology. 45:2365-2376
Activation induced deaminase (AID) initiates somatic hypermutation and class switch recombination of the Ig genes in antigen-activated B cells, underpinning antibody affinity maturation and isotype switching. AID can also be pathogenic by contributin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00b45ff2a84813d36613612f7d0dca9b
https://doi.org/10.1002/eji.201545462
https://doi.org/10.1002/eji.201545462
Autor:
Elena M. Cortizas, Astrid Zahn, Kohsuke Imai, Mani Larijani, Heather Fifield, Anne-Marie Patenaude, Javier M. Di Noia, Ramiro E. Verdun, Paul S. Foster, Anne Durandy, Stephen P. Methot, Anil K. Eranki
Publikováno v:
Proceedings of the National Academy of Sciences; Vol 111
Activation-induced deaminase (AID) triggers antibody class switch recombination (CSR) in B cells by initiating DNA double strand breaks that are repaired by nonhomologous end-joining pathways. A role for AID at the repair step is unclear. We show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc153011ed7f25a194c874fa25f4bb59