Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Astrid, Schweizer"'
Publikováno v:
Journal of Medicinal Chemistry. 65:10588-10610
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86c6f09daca944d39060283871ca764d
https://doi.org/10.1021/acs.jmedchem.2c00765
https://doi.org/10.1021/acs.jmedchem.2c00765
Autor:
Horst, Prescher, Astrid, Schweizer, Martin, Frank, Elena, Kuhfeldt, Julia, Ring, Lars, Nitschke
Publikováno v:
Journal of medicinal chemistry. 65(15)
Significant interest in the development of high-affinity ligands for Siglecs exists due to the various therapeutically relevant functions of these proteins. Here, we report a new strategy to develop and design Siglec ligands as disialyl-oligosacchari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7751f82e7a9a561894679d7c26762d5
https://pubmed.ncbi.nlm.nih.gov/35881556
https://pubmed.ncbi.nlm.nih.gov/35881556
Autor:
Chizuru, Akatsu, Amin, Alborzian Deh Sheikh, Naoko, Matsubara, Hiromu, Takematsu, Astrid, Schweizer, Hajjaj H M, Abdu-Allah, Thomas F, Tedder, Lars, Nitschke, Hideharu, Ishida, Takeshi, Tsubata
Publikováno v:
Science signaling. 15(723)
The protein tyrosine phosphatase CD45 plays a crucial role in B cell antigen receptor (BCR) signaling by activating Src family kinases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c784a7c9045a237cb1b4d174d6c8eb8
https://pubmed.ncbi.nlm.nih.gov/35230871
https://pubmed.ncbi.nlm.nih.gov/35230871
Autor:
Chizuru Akatsu, Amin Alborzian Deh Sheikh, Naoko Matsubara, Hiromu Takematsu, Astrid Schweizer, Hajjaj H. M. Abdu-Allah, Thomas F. Tedder, Lars Nitschke, Hideharu Ishida, Takeshi Tsubata
Publikováno v:
Science Signaling. 15
The protein tyrosine phosphatase CD45 plays a crucial role in B cell antigen receptor (BCR) signaling by activating Src family kinases.Cd45−/−mice show altered B cell development and a phenotype likely due to reduced steady-state signaling; howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5707de4aedd80f8e7689a44f71d01880
https://doi.org/10.1126/scisignal.abf9570
https://doi.org/10.1126/scisignal.abf9570
Publikováno v:
ChemBioChem. 18:1216-1225
CD22 is a member of the Siglec family. Considerable attention has been drawn to the design and synthesis of new Siglec ligands to explore target biology and innovative therapies. In particular, CD22-ligand-targeted nanoparticles with therapeutic func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9b56e1886f78836bdf4024f4a61e02
https://doi.org/10.1002/cbic.201600707
https://doi.org/10.1002/cbic.201600707
Autor:
Carsten Watzl, Reinhard Brossmer, Horst Prescher, Stephan Gütgemann, Elena Kuhfeldt, Lars Nitschke, Martin Frank, Astrid Schweizer
Publikováno v:
Journal of medicinal chemistry. 60(3)
Natural killer cells are able to directly lyse tumor cells, thereby participating in the immune surveillance against cancer. Unfortunately, many cancer cells use immune evasion strategies to avoid their eradication by the immune system. A prominent e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2e2c0bb7aaecf39c4bda17c13c97dc
https://pubmed.ncbi.nlm.nih.gov/28103033
https://pubmed.ncbi.nlm.nih.gov/28103033
Autor:
Lars Nitschke, Astrid Schweizer, Sandra Münch, Tim Sparwasser, Stephen M. Keyse, Magdalena Niedzielska, Marcus Derigs, Barbara Bodendorfer, Olivia Prazeres da Costa, Frauke Neff, Alexander Eichner, Roland Lang
Publikováno v:
J. Biol. Chem. 289, 2112-2126 (2014)
MAPK activity is negatively regulated by members of the dual specificity phosphatase (Dusp) family, which differ in expression, substrate specificity, and subcellular localization. Here, we investigated the function of Dusp16/MKP-7 in the innate immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4659c6e9061239c14a63fc42c450cbf4
https://doi.org/10.1074/jbc.m113.535245
https://doi.org/10.1074/jbc.m113.535245
Publikováno v:
European Journal of Immunology. 42:2792-2802
CD22 is an inhibitory co-receptor of the B-cell receptor (BCR) on B cells. Since CD22 is ubiquitously expressed in the B-cell lineage and CD22 endocytosis can be triggered efficiently, antibodies and antibody-based immunotoxins against CD22 are used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6b60e40261dde1afae4fe2f8fe023aa
https://doi.org/10.1002/eji.201242574
https://doi.org/10.1002/eji.201242574
Autor:
Lars Nitschke, Hans-Martin Jäck, Stephan M. Feller, Astrid Schweizer, Dirk Mielenz, Marcus Grohmann, Sebastian Brachs, Christiane Lang, Sebastian Dütting, Carmen Kroczek
Publikováno v:
The Journal of Immunology. 184:3665-3676
Compartmentalization of the BCR in membrane rafts is important for its signaling capacity. Swiprosin-1/EFhd2 (Swip-1) is an EF-hand and coiled-coil–containing adaptor protein with predicted Src homology 3 (SH3) binding sites that we identified in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2f6f2c7e3f68de884a160134da36e8
https://doi.org/10.4049/jimmunol.0903642
https://doi.org/10.4049/jimmunol.0903642
Publikováno v:
Quaternary Research. 71:307-318
The third millennium BP crisis of the central African rainforest is not sufficiently understood. The low resolution of most pollen profiles and a large plateau of the calibration curve aggravate the exact dating of the event, and its causal climatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a125e72dce40f77b510aa13880c93510
https://doi.org/10.1016/j.yqres.2008.12.002
https://doi.org/10.1016/j.yqres.2008.12.002