TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

Autor: Harshad S. Ugamraj, Kevin Dang, Laure-Hélène Ouisse, Benjamin Buelow, Eduardo N. Chini, Giulia Castello, James Allison, Starlynn C Clarke, Laura M. Davison, Roland Buelow, Rong Deng, Suhasini Iyer, Ute Schellenberger, Sankar N. Manika, Shipra Bijpuria, Astrid Musnier, Anne Poupon, Maria Cristina Cuturi, Wim van Schooten, Pranjali Dalvi

Publikováno v: mAbs, Vol 14, Iss 1 (2022)

Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolizes nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide. Other substrates of CD38 inclu

Externí odkaz: https://doaj.org/article/fdbba7fafcb24832b1853db840f82f25

4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis

Autor: Jérôme Granel, Roxane Lemoine, Eric Morello, Yann Gallais, Julie Mariot, Marion Drapeau, Astrid Musnier, Anne Poupon, Martine Pugnière, Seda Seren, Dalila Nouar, Valérie Gouilleux-Gruart, Hervé Watier, Brice Korkmaz, Cyrille Hoarau

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase. PR3-ANCA binding to membrane

Externí odkaz: https://doaj.org/article/7c2203b277ea43dd8313ce7bf3093377

A New in Silico Antibody Similarity Measure Both Identifies Large Sets of Epitope Binders with Distinct CDRs and Accurately Predicts Off-Target Reactivity

Autor: Astrid Musnier, Thomas Bourquard, Amandine Vallet, Laetitia Mathias, Gilles Bruneau, Mohammed Akli Ayoub, Ophélie Travert, Yannick Corde, Nathalie Gallay, Thomas Boulo, Sandra Cortes, Hervé Watier, Pascale Crépieux, Eric Reiter, Anne Poupon

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (17), pp.1-17. ⟨10.3390/ijms23179765⟩
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9765

International audience; Developing a therapeutic antibody is a long, tedious, and expensive process. Many obstacles need to be overcome, such as biophysical properties (issues of solubility, stability, weak production yields, etc.), as well as cross-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820601cc291909ac2734db5a3b47323c
https://doi.org/10.3390/ijms23179765

Exploring epitope and functional diversity of anti-SARS-CoV2 antibodies using AI-based methods

Autor: Hervé Watier, Nicolas Poirier, Anne Poupon, Christophe Dumet, Philippe Rivière, Astrid Musnier, Yann Jullian, Thomas Bourquard

SummarySince the beginning of the COVID19 pandemics, an unprecedented research effort has been conducted to analyze the antibody responses in patients, and many trials based on passive immunotherapy — notably monoclonal antibodies — are ongoing.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e10426e5b9c826b6626f9c8dc6bf74
https://hal-cnrs.archives-ouvertes.fr/hal-03091531

Methods to Determine Interaction Interfaces Between β-Arrestins and Their Protein Partners

Autor: Thomas, Bourquard, Astrid, Musnier, Aurélie, Tréfier, Flavie, Landomiel, Thomas, Boulo, Eric, Reiter, Pascale, Crépieux, Anne, Poupon

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1957

β-arrestins are so-called hub proteins: they make complexes with many different partners, assembling functional complexes, and thereby fulfilling their biological function. The importance of this process in G protein-coupled receptor (GPCR) signalli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5488315f292a5d664cf6ef247b28ad2c
https://pubmed.ncbi.nlm.nih.gov/30919355