Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Astrid, Lægreid"'
Autor:
Kathleen A. Heck, Håvard T. Lindholm, Barbara Niederdorfer, Eirini Tsirvouli, Martin Kuiper, Åsmund Flobak, Astrid Lægreid, Liv Thommesen
Publikováno v:
Proteomes, Vol 11, Iss 1, p 3 (2023)
Colorectal cancer (CRC) is one of the most prevalent cancers, driven by several factors including deregulations in intracellular signalling pathways. Small extracellular vesicles (sEVs) are nanosized protein-packaged particles released from cells, wh
Externí odkaz:
https://doaj.org/article/750dbd6bcab14f79b3d6cdf8f74b1b95
Autor:
Barbara Niederdorfer, Vasundra Touré, Miguel Vazquez, Liv Thommesen, Martin Kuiper, Astrid Lægreid, Åsmund Flobak
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Discrete dynamical modeling shows promise in prioritizing drug combinations for screening efforts by reducing the experimental workload inherent to the vast numbers of possible drug combinations. We have investigated approaches to predict combination
Externí odkaz:
https://doaj.org/article/9646a10c30a64b28b8fde52fa58f74b4
Autor:
Evelina Folkesson, Barbara Niederdorfer, Vu To Nakstad, Liv Thommesen, Geir Klinkenberg, Astrid Lægreid, Åsmund Flobak
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ee22fedb649e487bb2c164209c05ebd1
Autor:
Sophia Müller-Dott, Eirini Tsirvouli, Miguel Vázquez, Ricardo O. Ramirez Flores, Pau Badia-i-Mompel, Robin Fallegger, Astrid Lægreid, Julio Saez-Rodriguez
Gene regulation plays a critical role in the cellular processes that underlie human health and disease. The regulatory relationship between transcription factors (TFs), key regulators of gene expression, and their target genes, the so called TF regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::796be2c0ad987e449e1d5d0eff1c62fe
https://doi.org/10.1101/2023.03.30.534849
https://doi.org/10.1101/2023.03.30.534849
Publikováno v:
Medicine, Health Care, and Philosophy
In this paper, we tell the story of efforts currently underway, on diverse fronts, to build digital knowledge repositories (‘knowledge-bases’) to support research in the life sciences. If successful, knowledge bases will be part of a new knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de755eed1e99cc8917c09cc47119506
https://doi.org/10.1007/s11019-020-09957-0
https://doi.org/10.1007/s11019-020-09957-0
Autor:
Miguel Vazquez, Martin Krallinger, Florian Leitner, Martin Kuiper, Alfonso Valencia, Astrid Laegreid
Publikováno v:
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Universitat Politècnica de Catalunya (UPC)
The regulation of gene transcription by transcription factors is a fundamental biological process, yet the relations between transcription factors (TF) and their target genes (TG) are still only sparsely covered in databases. Text-mining tools can of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4809196e947b6ab03355e5f65cae3487
https://hdl.handle.net/2117/367522
https://hdl.handle.net/2117/367522
Autor:
Åsmund Flobak, Anaïs Baudot, Elisabeth Remy, Liv Thommesen, Denis Thieffry, Martin Kuiper, Astrid Lægreid
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004426 (2015)
Discovery of efficient anti-cancer drug combinations is a major challenge, since experimental testing of all possible combinations is clearly impossible. Recent efforts to computationally predict drug combination responses retain this experimental se
Externí odkaz:
https://doaj.org/article/7e5ab149cfc74114ab3d783953ef9aa2
Autor:
Noemi del Toro, Prisca Lo Surdo, Marcio Luis Acencio, Gianni Cesareni, Astrid Lægreid, Henning Hermjakob, Tamas Korcsmaros, John Zobolas, Glyn Bradley, Sandra Orchard, Luana Licata, Ruth C. Lovering, Paul Thomas, Vasundra Touré, Pablo Porras, Livia Perfetto, Martin Kuiper, Dávid Fazekas
Publikováno v:
Bioinformatics
Motivation Combining multiple layers of information underlying biological complexity into a structured framework represent a challenge in systems biology. A key task is the formalization of such information in models describing how biological entitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93eb97f57359583d9a3e1262454ff773
https://doi.org/10.1093/bioinformatics/btz132
https://doi.org/10.1093/bioinformatics/btz132
Autor:
Linn-Karina M Selvik, Shalini Rao, Tonje S Steigedal, Ildri Haltbakk, Kristine Misund, Torunn Bruland, Wenche S Prestvik, Astrid Lægreid, Liv Thommesen
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112485 (2014)
Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced levels of SIK1 are associated w
Externí odkaz:
https://doaj.org/article/c69c5cdade9b424298d2bd7440a596f8
Formalization of gene regulation knowledge using ontologies and gene ontology causal activity models
Autor:
María del Mar Roldán-García, José Antonio Vera-Ramos, Belén Juanes Cortés, Stefan Schulz, Martin Kuiper, Astrid Lægreid, Pascale Gaudet, Ruth C. Lovering, Colin Logie, Jesualdo Tomás Fernández-Breis
Publikováno v:
Biochimica et Biophysica Acta, Gene Regulatory Mechanisms, 1864, 11-12, pp. 1-13
Biochimica et Biophysica Acta, Gene Regulatory Mechanisms, 1864, 1-13
Biochimica et Biophysica Acta, Gene Regulatory Mechanisms, 1864, 1-13
Gene regulation computational research requires handling and integrating large amounts of heterogeneous data. The Gene Ontology has demonstrated that ontologies play a fundamental role in biological data interoperability and integration. Ontologies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8613f02eaa6e3e72b2bc86a5be09ea4
https://pubmed.ncbi.nlm.nih.gov/34710644
https://pubmed.ncbi.nlm.nih.gov/34710644