CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target

Autor: Astrid Drenckhan, Morton Freytag, Claudiu T. Supuran, Guido Sauter, Jakob R. Izbicki, Stephanie J. Gros

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1024-1033 (2018)

The hypoxic tumour microenvironment of solid tumours represents an important starting point for modulating progression and metastatic spread. Carbonic anhydrase IX (CAIX) is a known HIF-1α-dependent key player in maintaining cell pH conditions under

Externí odkaz: https://doaj.org/article/f578c1902d0f4b5585eae8497dea9bcf

Metastatic Esophageal Carcinoma Cells Exhibit Reduced Adhesion Strength and Enhanced Thermogenesis

Autor: Jakob R. Izbicki, Mariana Sá Santos, Zihe Huo, Michael A. Nash, Stefan Holland-Cunz, Stephanie J. Gros, Astrid Drenckhan

Publikováno v: Cells, Vol 10, Iss 1213, p 1213 (2021)
Cells
Cells, 10 (5)
Volume 10
Issue 5

Despite continuous improvements in multimodal therapeutic strategies, esophageal carcinoma maintains a high mortality rate. Metastases are a major life-limiting component; however, very little is known about why some tumors have high metastatic poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2df802ff129a11cb28e846f5d38a1d0
https://www.mdpi.com/2073-4409/10/5/1213

Correction: Involvement of CXCR4 Chemokine Receptor in Metastastic HER2-Positive Esophageal Cancer.

Autor: Stephanie J. Gros, Nina Kurschat, Astrid Drenckhan, Thorsten Dohrmann, Evelyn Forberich, Katharina Effenberger, Uta Reichelt, Robert M. Hoffman, Klaus Pantel, Jussuf T. Kaifi, Jakob R. Izbicki

Publikováno v: PLoS ONE, Vol 8, Iss 5 (2013)

Externí odkaz: https://doaj.org/article/b07f36998b8b40ad8f5fdea0b3560b75

CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target

Autor: Morton Freytag, Jakob R. Izbicki, Guido Sauter, Stephanie J. Gros, Astrid Drenckhan, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1024-1033 (2018)

The hypoxic tumour microenvironment of solid tumours represents an important starting point for modulating progression and metastatic spread. Carbonic anhydrase IX (CAIX) is a known HIF-1α-dependent key player in maintaining cell pH conditions under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c061cffa3a955b814571410e6b46ef91
https://doi.org/10.1080/14756366.2018.1475369

ErbB2 signaling activates the Hedgehog pathway via PI3K–Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts

Autor: Jakob R. Izbicki, Alexander Schultze, Manfred Jücker, Maxim Kebenko, Astrid Grottke, Nicole Grabinski, Astrid Drenckhan, Florian Ewald, Carsten Bokemeyer, Walter Fiedler, Jasmin Wellbrock, Stephanie J. Gros

Publikováno v: Cellular Signalling. 27:373-381

The Hedgehog pathway plays an important role in the pathogenesis of several tumor types, including esophageal cancer. In our study, we show an expression of the ligand Indian hedgehog (Ihh) and its downstream mediator Gli-1 in primary resected adenoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3609bef611271d9cd8c4a7da19de0c34
https://doi.org/10.1016/j.cellsig.2014.11.022