Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Astar Winoto"'
Publikováno v:
Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 468-479 (2020)
Abstract Introduction Priming of tumor‐specific T cells is a key to antitumor immune response and inflammation, in turn, is crucial for proper T‐cell activation. As antigen‐presenting cells can activate T cells, dendritic cells (DCs) loaded wit
Externí odkaz:
https://doaj.org/article/e4b59616a6b848acbc338b684affcd3a
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1932-1944 (2013)
The relationship between dendritic cells (DCs) and commensal microflora in shaping systemic immune responses is not well understood. Here, we report that mice deficient for the Fas-associated death domain in DCs developed systemic inflammation associ
Externí odkaz:
https://doaj.org/article/25228278daae472a89b6c7a3f59b4a58
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005845 (2016)
Hematopoietic stem cells are capable of self-renewal or differentiation along three main lineages: myeloid, erythroid, and lymphoid. One of the earliest lineage decisions for blood progenitor cells is whether to adopt the lymphoid or myeloid fate. Pr
Externí odkaz:
https://doaj.org/article/d10d7e8c909b4e28b6e1ba81fdfeb04b
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124391 (2015)
Myeloid cells, which include monocytes, macrophages, and granulocytes, are important innate immune cells, but the mechanism and downstream effect of their cell death on the immune system is not completely clear. Necroptosis is an alternate form of ce
Externí odkaz:
https://doaj.org/article/fb8f9ecf77a6468092c1b3654171c109
Publikováno v:
eLife, Vol 3 (2014)
T cell self-tolerance is thought to involve peripheral tolerance and negative selection, involving apoptosis of autoreactive thymocytes. However, evidence supporting an essential role for negative selection is limited. Loss of Bim, a Bcl-2 BH3-only p
Externí odkaz:
https://doaj.org/article/c5738485ef0b481f8047126c3e357172
Autor:
Heather Melichar, Ou Li, Jenny Ross, Hilary Haber, Dragana Cado, Hector Nolla, Ellen A Robey, Astar Winoto
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19854 (2011)
Directed differentiation of human embryonic stem cells (hESCs) into any desired cell type has been hailed as a therapeutic promise to cure many human diseases. However, substantial roadblocks still exist for in vitro differentiation of hESCs into dis
Externí odkaz:
https://doaj.org/article/bc2b318e34d84e0d8b623bda43341e43
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9229 (2010)
FoxM1 is a forkhead box transcription factor and a known master regulator required for different phases of the cell cycle. In cell lines, FoxM1 deficient cells exhibit delayed S phase entry, aneuploidy, polyploidy and can't complete mitosis. In vivo,
Externí odkaz:
https://doaj.org/article/1dd4e84fa0de48b590828151828394d5
Publikováno v:
Immunity, Inflammation and Disease
Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 468-479 (2020)
Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 468-479 (2020)
Introduction Priming of tumor‐specific T cells is a key to antitumor immune response and inflammation, in turn, is crucial for proper T‐cell activation. As antigen‐presenting cells can activate T cells, dendritic cells (DCs) loaded with tumor a
Publikováno v:
The Journal of biological chemistry, vol 293, iss 13
Apoptosis is mediated through the extrinsic or intrinsic pathway. Key regulators of the intrinsic apoptotic pathway are the family of B cell lymphoma 2 (Bcl-2) proteins. The activity of the prototypical Bcl-2 protein is usually considered antiapoptot
Autor:
Laurent Coscoy, Neha V Chandra, Takashi Irie, Bin Gotoh, Astar Winoto, Suruchi N. Schock, Yoshinori Kitagawa, Yuefang Sun
Publikováno v:
Cell death and differentiation, vol 24, iss 4
Necroptosis is a form of necrotic cell death that requires the activity of the death domain-containing kinase RIP1 and its family member RIP3. Necroptosis occurs when RIP1 is deubiquitinated to form a complex with RIP3 in cells deficient in the death