Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics

Autor: Tom M. Quinn, Erin E. Gaughan, Annya Bruce, Jean Antonelli, Richard O'Connor, Feng Li, Sarah McNamara, Oliver Koch, Claire MacKintosh, David Dockrell, Timothy Walsh, Kevin G. Blyth, Colin Church, Jürgen Schwarze, Cecilia Boz, Asta Valanciute, Matthew Burgess, Philip Emanuel, Bethany Mills, Giulia Rinaldi, Gareth Hardisty, Ross Mills, Emily Gwyer Findlay, Sunny Jabbal, Andrew Duncan, Sinéad Plant, Adam D.L. Marshall, Irene Young, Kay Russell, Emma Scholefield, Alastair F. Nimmo, Islom B. Nazarov, Grant C. Churchill, James S.O. McCullagh, Kourosh H. Ebrahimi, Colin Ferrett, Kate Templeton, Steve Rannard, Andrew Owen, Anne Moore, Keith Finlayson, Manu Shankar-Hari, John Norrie, Richard A. Parker, Ahsan R. Akram, Daniel C. Anthony, James W. Dear, Nik Hirani, Kevin Dhaliwal

Publikováno v: EBioMedicine, Vol 76, Iss , Pp 103856- (2022)

Summary: Background: Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is nafamostat mesylate. Methods: We present the

Externí odkaz: https://doaj.org/article/30aabc317f5544bcb011f0340db28762

An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE):A Phase Ib/IIa Randomised Controlled Trial

Autor: Erin E, Gaughan, Tom M, Quinn, Andrew, Mills, Annya M, Bruce, Jean, Antonelli, Alison, MacKinnon, Vassilios, Aslanis, Feng, Li, Richard, O'Connor, Cecilia, Boz, Ross, Mills, Philip, Emanuel, Matthew, Burgess, Giulia, Rinaldi, Asta, Valanciute, Bethany, Mills, Emma, Scholefield, Gareth, Hardisty, Emily, Gwyer Findlay, Richard A, Parker, John, Norrie, James W, Dear, Ahsan R, Akram, Oliver, Koch, Kate, Templeton, David H, Dockrell, Timothy S, Walsh, Stephen, Partridge, Duncan, Humphries, Jie, Wang-Jairaj, Robert J, Slack, Hans, Schambye, De, Phung, Lise, Gravelle, Bertil, Lindmark, Manu, Shankar-Hari, Nikhil, Hirani, Tariq, Sethi, Kevin, Dhaliwal

Publikováno v: Gaughan, E E, Quinn, T M, Mills, A, Bruce, A M, Antonelli, J, Mackinnon, A, Aslanis, V, Li, F, O'connor, R, Boz, C, Mills, R, Emanuel, P, Burgess, M, Rinaldi, G, Valanciute, A, Mills, B, Scholefield, E, Hardisty, G, Gwyer Findlay, E, Parker, R A, Norrie, J, Dear, J W, Akram, A R, Koch, O, Templeton, K, Dockrell, D H, Walsh, T S, Partridge, S, Humphries, D, Wang-jairaj, J, Slack, R J, Schambye, H, Phung, D, Gravelle, L, Lindmark, B, Shankar-Hari, M, Hirani, N, Sethi, T & Dhaliwal, K 2022, ' An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE) : A Phase Ib/IIa Randomised Controlled Trial ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.202203-0477OC

Rationale: High circulating galectin-3 is associated with poor outcomes in patients with COVID-19. We hypothesised that GB0139, a potent inhaled thiodigalactoside galectin-3 inhibitor with anti-inflammatory and antifibrotic actions, would be safely a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4cbdceb9f003b857818278fa3a4d79ec
https://www.pure.ed.ac.uk/ws/files/298426001/rccm.202203_0477oc_1_.pdf

Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID Pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics

Autor: Oliver Koch, Andrew Duncan, Jean Antonelli, Timothy S. Walsh, Annya Bruce, Kay Russell, Colin Ferrett, Colin Church, James S. O. McCullagh, Jürgen Schwarze, Cecilia Boz, Giulia Rinaldi, Sinéad Plant, Gareth Hardisty, Anne Moore, Ahsan R. Akram, Kourosh Honarmand Ebrahimi, Sarah McNamara, Feng Li, Kevin G. Blyth, K. Dhaliwal, David H. Dockrell, Asta Valanciute, Ross Mills, Bethany Mills, Claire L. Mackintosh, Daniel C. Anthony, Tom Quinn, Steve P. Rannard, John Norrie, Irene Young, Keith Finlayson, Kate Templeton, Alastair F. Nimmo, Richard A. O’Connor, Erin Gaughan, Emma Scholefield, James W. Dear, Richard Parker, Andrew Owen, Philip Emanuel, Manu Shankar-Hari, Grant C. Churchill, Adam Marshall, Nik Hirani, Islom B. Nazarov, Matthew Burgess, Emily Gwyer Findlay, Sunny Jabball

Publikováno v: Quinn, T, Gaughan, E E, Bruce, A, Antonelli, J, O'Connor, R A, Li, F, McNamara, S, Koch, O, Mackintosh, C, Dockrell, D, Walsh, T, Blyth, K G, Church, C, Schwarze, J, Boz, C, Valanciute, A, Burgess, M, Emanuel, P, Mills, B, Rinaldi, G, Hardisty, G, Mills, R, Gwyer Findlay, E L, Jabbal, S, Duncan, A, Plant, S, Marshall, A D L, Young, I, Russell, K, Scholefield, E, Nimmo, A F, Nazarov, I B, Churchill, G C, McCullagh, J S O, Ebrahimi, K H, Ferrett, C, Templeton, K E, Rannard, S, Owen, A, Moore, A, Finlayson, K, Shankar-Hari, M, Akram, A R, Parker, R A, Dear, J W, Hirani, N & Dhaliwal, K 2022, ' Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2022.103856
EBioMedicine, Vol 76, Iss, Pp 103856-(2022)

Despite the success of vaccines and selected repurposed treatments, COVID-19 is likely to remain a global health problem and further chemotherapeutics are required. Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials without charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08984770a1c6b75fcf7ed0f83784327
https://doi.org/10.2139/ssrn.3958859

Aspirin-mediated DKK-1 increase rescues Wnt-driven stem-like phenotype in human intestinal organoids

Autor: Kevin Myant, T. Jamieson, Dunbar K, Susan M. Farrington, Owen J. Sansom, Rajasekaran, Vinuela Pf, Mark J. Arends, Lima A, Malcolm G. Dunlop, Asta Valanciute, Ochocka-Fox A, Farhat V N Din, James P. Blackmur

Aspirin reduces the incidence and mortality of colorectal cancer (CRC). Wnt signalling drives CRC development from initiation to progression through regulation of epithelial-mesenchymal transition (EMT) and cancer stem cell populations (CSC). Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072c9f3e801df3745576843a56a18b65

Meet the science

Autor: Asta Valanciute, Covadonga Huidobro

Publikováno v: The Biochemist. 37:50

On the 22 September 2014, two researchers from the University of Edinburgh, Covadonga Huidobro and Asta Valanciute, arrived at the High School in Plateliai, Lithuania. There were plenty of educational resources, including bags of different coloured b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7866218d0329531686db176025c06e7
https://doi.org/10.1042/bio03701050