Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Asta, Laiho"'
Autor:
Kimmo Kettunen, Julia Mathlin, Tarja Lamminen, Asta Laiho, Merja R. Häkkinen, Seppo Auriola, Laura L. Elo, Peter J. Boström, Matti Poutanen, Pekka Taimen
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105359- (2024)
Summary: Background: Bladder cancer is a highly over-represented disease in males. The involvement of sex steroids in bladder carcinogenesis and the utilisation of steroid hormone action as a therapeutic target have been frequently proposed. However,
Externí odkaz:
https://doaj.org/article/d13519fb20bb47958a821925404ff551
Autor:
Tanja Buchacher, Ankitha Shetty, Saara A. Koskela, Johannes Smolander, Riina Kaukonen, António G.G. Sousa, Sini Junttila, Asta Laiho, Olof Rundquist, Tapio Lönnberg, Alexander Marson, Omid Rasool, Laura L. Elo, Riitta Lahesmaa
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113469- (2023)
Summary: The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (i.e., PIM1, PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are downstream of several cytokine signaling pathways that drive immune-m
Externí odkaz:
https://doaj.org/article/3a090e9a93c647a8b4fb1957f69538cc
Autor:
Astrid Oras, Henna Kallionpää, Tomi Suomi, Satu Koskinen, Asta Laiho, Laura L. Elo, Mikael Knip, Riitta Lahesmaa, Alar Aints, Raivo Uibo
Publikováno v:
Heliyon, Vol 9, Iss 2, Pp e13147- (2023)
Background: In coeliac disease (CoD), the role of B-cells has mainly been considered to be production of antibodies. The functional role of B-cells has not been analysed extensively in CoD. Methods: We conducted a study to characterize gene expressio
Externí odkaz:
https://doaj.org/article/94febd692ccf486ebc7319ba6a3af836
Autor:
Johannes Smolander, Sofia Khan, Kalaimathy Singaravelu, Leni Kauko, Riikka J. Lund, Asta Laiho, Laura L. Elo
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Detection of copy number variations (CNVs) from high-throughput next-generation whole-genome sequencing (WGS) data has become a widely used research method during the recent years. However, only a little is known about the applica
Externí odkaz:
https://doaj.org/article/dc83a894cd3b4d2189a7798343171802
Autor:
Riikka Huhtaniemi, Petra Sipilä, Arttu Junnila, Riikka Oksala, Matias Knuuttila, Arfa Mehmood, Eija Aho, Teemu D. Laajala, Tero Aittokallio, Asta Laiho, Laura Elo, Claes Ohlsson, Malin Hagberg Thulin, Pekka Kallio, Sari Mäkelä, Mika V.J. Mustonen, Matti Poutanen
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104287- (2022)
Summary: Antiandrogen treatment resistance is a major clinical concern in castration-resistant prostate cancer (CRPC) treatment. Using xenografts of VCaP cells we showed that growth of antiandrogen resistant CRPC tumors were characterized by a higher
Externí odkaz:
https://doaj.org/article/125d518783f44b70a3bc79f19094057c
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Objective Visualization of sequencing data is an integral part of genomic data analysis. Although there are several tools to visualize sequencing data on genomic regions, they do not offer user-friendly ways to view simultaneously different
Externí odkaz:
https://doaj.org/article/9aa739ad4d75448aa229786fcc00958e
Autor:
Fu-Ping Zhang, Marjo Malinen, Arfa Mehmood, Tiina Lehtiniemi, Tiina Jääskeläinen, Einari A. Niskanen, Hanna Korhonen, Asta Laiho, Laura L. Elo, Claes Ohlsson, Noora Kotaja, Matti Poutanen, Petra Sipilä, Jorma J. Palvimo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
SUMOylation is known to regulate androgen receptor (AR) activity in cultured cells. Here, using SUMOylation-deficient AR knock-in mice, the authors demonstrate that SUMOylation is required for AR-related gene expression specifically in the epididymal
Externí odkaz:
https://doaj.org/article/7bfcbcb37546416dbab210522f05d0c2
Autor:
Alexandra Franziska Gülich, Ramona Rica, Caroline Tizian, Csilla Viczenczova, Kseniya Khamina, Thomas Faux, Daniela Hainberger, Thomas Penz, Remy Bosselut, Christoph Bock, Asta Laiho, Laura L. Elo, Andreas Bergthaler, Wilfried Ellmeier, Shinya Sakaguchi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The BTB zinc finger transcription factor MAZR (also known as PATZ1) controls, partially in synergy with the transcription factor Runx3, the development of CD8 lineage T cells. Here we explored the role of MAZR as well as combined activities of MAZR/R
Externí odkaz:
https://doaj.org/article/4b233b2a316e48e78a3000b1d9d5c593
Autor:
Liisa Andersen, Alexandra Franziska Gülich, Marlis Alteneder, Teresa Preglej, Maria Jonah Orola, Narendra Dhele, Valentina Stolz, Alexandra Schebesta, Patricia Hamminger, Anastasiya Hladik, Stefan Floess, Thomas Krausgruber, Thomas Faux, Syed Bilal Ahmad Andrabi, Jochen Huehn, Sylvia Knapp, Tim Sparwasser, Christoph Bock, Asta Laiho, Laura L. Elo, Omid Rasool, Riitta Lahesmaa, Shinya Sakaguchi, Wilfried Ellmeier
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4447-4459.e6 (2019)
Summary: Forkhead box protein P3+ (FOXP3+) regulatory T cells (Treg cells) play a key role in maintaining tolerance and immune homeostasis. Here, we report that a T cell-specific deletion of the transcription factor MAZR (also known as PATZ1) leads t
Externí odkaz:
https://doaj.org/article/974129bdad3742e980b60d2cd2ed4c8c
Autor:
Riikka J. Lund, Nelly Rahkonen, Maia Malonzo, Leni Kauko, Maheswara Reddy Emani, Virpi Kivinen, Elisa Närvä, Esko Kemppainen, Asta Laiho, Heli Skottman, Outi Hovatta, Omid Rasool, Matti Nykter, Harri Lähdesmäki, Riitta Lahesmaa
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1442-1454 (2017)
POLR3G is expressed at high levels in human pluripotent stem cells (hPSCs) and is required for maintenance of stem cell state through mechanisms not known in detail. To explore how POLR3G regulates stem cell state, we carried out deep-sequencing anal
Externí odkaz:
https://doaj.org/article/f5149f7793d441839007ecae5f814030