Výsledky vyhledávání - "Assunta Pelosi"

Akademický článek

BDNF/TrkB pathway activation in D1 receptor-expressing striatal projection neurons plays a protective role against L-DOPA-induced dyskinesia

Autor: Assunta Pelosi, Yukari Nakamura, Jean-Antoine Girault, Denis Hervé

Publikováno v: Neurobiology of Disease, Vol 185, Iss , Pp 106238- (2023)

L-DOPA-induced dyskinesia (LID) is a frequent adverse side effect of L-DOPA treatment in Parkinson's disease (PD). Understanding the mechanisms underlying the development of these motor disorders is needed to reduce or prevent them. We investigated t

Externí odkaz: https://doaj.org/article/d361d3c9e24f4e858b6df0062ca66e99

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Akademický článek

Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia

Autor: Hind Baba Aïssa, Romain W Sala, Elena Laura Georgescu Margarint, Jimena Laura Frontera, Andrés Pablo Varani, Fabien Menardy, Assunta Pelosi, Denis Hervé, Clément Léna, Daniela Popa

Publikováno v: eLife, Vol 11 (2022)

Dystonia is often associated with functional alterations in the cerebello-thalamic pathways, which have been proposed to contribute to the disorder by propagating pathological firing patterns to the forebrain. Here, we examined the function of the ce

Externí odkaz: https://doaj.org/article/391de5d281cd4f9eac4bcbc72f75cfef

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Akademický článek

fMRI detects bilateral brain network activation following unilateral chemogenetic activation of direct striatal projection neurons

Autor: Yuki Nakamura, Yukari Nakamura, Assunta Pelosi, Boucif Djemai, Clément Debacker, Denis Hervé, Jean-Antoine Girault, Tomokazu Tsurugizawa

Publikováno v: NeuroImage, Vol 220, Iss , Pp 117079- (2020)

Abnormal structural and functional connectivity in the striatum during neurological disorders has been reported using functional magnetic resonance imaging (fMRI), although the effects of cell-type specific neuronal stimulation on fMRI and related be

Externí odkaz: https://doaj.org/article/a4351e6d5cea48cfbe179300e52b9e8f

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Akademický článek

Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.

Autor: Assunta Pelosi, Jean-Antoine Girault, Denis Hervé

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0137185 (2015)

Grooming behaviour is the most common innate behaviour in animals. In rodents, it consists of sequences of movements organized in four phases, executed symmetrically on both sides of the animal and creating a syntactic chain of behavioural events. Th

Externí odkaz: https://doaj.org/article/bbf90234d3d3424f85fe6f49858da1c1

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Akademický článek

Identification of a novel gene product that promotes survival of Mycobacterium smegmatis in macrophages.

Autor: Assunta Pelosi, Danielle Smith, Rajini Brammananth, Agnieszka Topolska, Helen Billman-Jacobe, Phillip Nagley, Paul K Crellin, Ross L Coppel

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31788 (2012)

BACKGROUND: Bacteria of the suborder Corynebacterineae include significant human pathogens such as Mycobacterium tuberculosis and M. leprae. Drug resistance in mycobacteria is increasingly common making identification of new antimicrobials a priority

Externí odkaz: https://doaj.org/article/5ebb6d80aa06441c8cb035de2ce70b47

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Akademický článek

The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep.

Autor: Assunta Pelosi, David Piedrafita, Giorgio De Guzman, Robert Shepherd, John D Hamill, Els Meeusen, Amanda M Walmsley

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52907 (2012)

Antigen-specific antibody responses against a model antigen (the B subunit of the heat labile toxin of enterotoxigenic Escherichia coli, LTB) were studied in sheep following oral immunisation with plant-made and delivered vaccines. Delivery from a ro

Externí odkaz: https://doaj.org/article/ebbe4208f1ce4abda6262188e9d61a6b

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