Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Assunta Imperato"'
Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse
Autor:
Assunta Imperato, G Cossu, Georg Andrees Bohme, Marc Parmentier, Walter Fratta, Liana Fattore, Catherine Ledent
Publikováno v:
Behavioural Brain Research. 118:61-65
The rewarding effects of morphine, cocaine, amphetamine and nicotine were evaluated in CB1 receptor knockout mice by means of an intravenous self-administration model. Experiments were carried out on drug-naive animals using a nose-poking response (N
Autor:
Jean-Marie Stutzmann, Marc Williams Debono, Alain Boireau, Arielle Genevois-Borella, Michel Cheve, Dominique Damour, Assunta Imperato, John Randle, Yves Ribeill, Jeremy Pratt, Serge Mignani, Patrick Jimonet, Marc Vuilhorgne, Georg Andrees Bohme
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:2211-2217
Water soluble 8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e]pyraz ine-4-one 4 represents a novel class of highly potent and selective AMPA receptors antagonists with in vivo activity. The dextrorotatory isomer (+)-4 was found to displa
Autor:
Walter Fratta, Assunta Imperato, Georg Andrees Bohme, G Cossu, M. C. Obinu, C. Ledent, Maria Stefania Mascia, M. Parmentier, Liana Fattore
Publikováno v:
Pharmacy and Pharmacology Communications. 6:281-285
It has been reported that, as well as morphine, the cannabinoid CB1 receptor agonist WIN 55,212-2 failed to induce intravenous self- administration in mutant CB1 receptor knockout (CB1(-/-)) mice but not in the corresponding wild type (CB1(+/+)) mice
Autor:
Jeremy Pratt, Arielle Genevois-Borella, Michel Cheve, Georg Andrees Bohme, Yves Ribeill, Franco Manfre, Patrick Jimonet, Jean Marie Stutzmann, Alain Boireau, S. Le Guern, A. Doble, John Randle, Serge Mignani, F. Herman, Dominique Damour, Assunta Imperato
Publikováno v:
Journal of Medicinal Chemistry. 43:2371-2381
Indeno[1,2-b]pyrazin-2,3-diones have been identified as a novel series of potent ligands on the glycine site of the NMDA receptor. To improve their in vivo activities, an acetic acid-type side chain was introduced to the 5-position, giving water-solu
Publikováno v:
Neuropharmacology. 39:1016-1020
Riluzole, has previously been shown to be protective in animal models of Parkinson's disease in vivo. In the present study the effects of riluzole on the intrastriatal formation and accumulation of MPP(+), after i.p. injection of MPTP were tested in
Autor:
Jean-Marie Stutzmann, Marc Vuilhorgne, Yves Ribeill, Serge Mignani, Jeremy Pratt, Patrick Jimonet, Dominique Damour, Alain Boireau, Marc Williams Debono, Georg Andrees Bohme, John Randle, Assunta Imperato, Arielle Genevois-Borella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1133-1137
A novel series of 2-substituted-4,5-dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazine derivatives was synthesised. One of them, Figure 1 , Scheme 1 Download : Download high-res image (100KB) Download : Download full-size image Figure 1 . Download
Autor:
Bernard Brugg, Assunta Imperato, Gerda Huber, Anne-Marie Haeberlé, Catherine Ribaut‐Barassin, Jean Mariani, Saliha Moussaoui, Yannick Bailly, Nicole Delhaye-Bouchaud
Publikováno v:
Synapse. 35:96-110
Healthy brain neurons co-express Alzheimer's disease (AD) related proteins presenilins (PS) and beta-amyloid precursor protein (beta-APP). Deposition of beta-amyloid and PS in the senile plaques of AD brain and their ability to interact in vitro sugg
Autor:
Yves Ribeill, John Randle, Michel Reibaud, Jeremy Pratt, Jean-Marie Stutzmann, J.‐C. Blanchard, Alain Boireau, Marie-Christine Dubroeucq, Arielle Genevois-Borella, Marc-Williams Debono, Serge Mignani, Dominique Damour, Jean-Claude Aloup, Patrick Jimonet, Assunta Imperato, Georg Andrees Bhme, Michel Barreau
Publikováno v:
Drug Development Research. 48:121-129
The excessive release of glutamate, a potent excitatory neurotransmitter, is thought to play an important role in a variety of acute and chronic neurological disorders. Consequently, excitatory amino acid antagonists may have an important therapeutic
Autor:
Mireille Meunier, Saliha Moussaoui, Pierre Dubedat, Francoise Bordier, Assunta Imperato, Madeleine Coimbra, Alain Boireau
Publikováno v:
Annals of the New York Academy of Sciences. 893:254-257
Autor:
Jean-Marie Stutzmann, John Randle, Assunta Imperato, Michel Cheve, Yves Ribeill, Jeremy Pratt, Dominique Damour, Arielle Genevois-Borella, Patrick Jimonet, Serge Mignani, Alain Boireau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2921-2926
Original spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives were synthesised and led to the identification of 3e which showed good affinities for both the AMPA and the NMDA glycine-site receptors, and displayed good anticonvulsant effects af