Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues

Autor: Joshua C. Bis, Holger Kirsten, Wolfgang Rathmann, Albert Hofman, Shih-Jen Hwang, Stefan Weiss, Annette Peters, Oscar H. Franco, Klodian Dhana, Brenda W J H Penninx, Katharina Schramm, Christian Herder, Joseph F. Polak, Adrie Seldenrijk, Wolfgang Koenig, Markus Loeffler, Marcus Dörr, Andy B Castaneda, Petra Wolf, Frank Beutner, Christopher J. O’Donnell, Xiaoling Zhang, Jochen Seissler, Christa Meisinger, Joachim Thiery, Holger Prokisch, Rick Jansen, Joyce B. J. van Meurs, André G. Uitterlinden, Nora Franceshini, Jennifer E. Below, Georg Homuth, Paul S. de Vries, Daniel Levy, Marjolein J. Peters, Cohorts for Heart, Gerard van Grootheest, Abbas Dehghan, Markus Scholz, Ulf Schminke, Carola Marzi, Melanie Waldenberger, Knut Krohn, Claudia Giambartolomei, Lauren E. Petty, Maryam Kavousi, Henry Völzke

Publikováno v: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Subclinical Working Group 2022, ' Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues ', Human Molecular Genetics, vol. 31, no. 7, pp. 1171-1182 . https://doi.org/10.1093/hmg/ddab236, https://doi.org/10.1093/hmg/ddab236
Human Molecular Genetics, 31(7), 1171-1182. Oxford University Press
Hum Mol Genet

Carotid intima media thickness (cIMT) is a biomarker of subclinical atherosclerosis and a predictor of future cardiovascular events. Identifying associations between gene expression levels and cIMT may provide insight to atherosclerosis etiology. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fc58ef9e80951689e00a99b96d510b
https://pure.eur.nl/en/publications/d15b4fdb-5cf3-402f-9f22-00ca24fa6759

A genome-first approach to rare variants in hypertrophic cardiomyopathy genes MYBPC3 and MYH7 in a medical biobank

Autor: Michael G. Levin, Marylyn D. Ritchie, Sharlene M. Day, Joseph Park, Daniel J. Rader, Scott M. Damrauer, Renae Judy, Elizabeth A Packard

Publikováno v: Hum Mol Genet

‘Genome-first’ approaches to analyzing rare variants can reveal new insights into human biology and disease. Because pathogenic variants are often rare, new discovery requires aggregating rare coding variants into ‘gene burdens’ for sufficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2209122f94f8f922c4ebff991f36771
https://doi.org/10.1093/hmg/ddab249

Epigenome-wide association study of mitochondrial genome copy number

Autor: Penglong Wang, Kent D. Taylor, Xianbang Sun, Xiuqing Guo, Jie Yao, JoAnn E. Manson, Jeffrey Haessler, Yongmei Liu, Alexander P. Reiner, Daniel Levy, Eric Boerwinkle, Jennifer A. Smith, David Van Den Berg, Dan E. Arking, Tuuli Lappalainen, Jan Bressler, Lifang Hou, Christina A. Castellani, Stephen S. Rich, Wei Zhao, Tianxiao Huan, Silva Kasela, Megan L. Grove, Chunyu Liu, Patricia A. Peyser, Jerome I. Rotter, Lawrence F. Bielak, Joehanes Roby, Charles Kooperberg, Myriam Fornage, Ryan J. Longchamps

Publikováno v: Hum Mol Genet

We conducted cohort- and race-specific epigenome-wide association analyses of mitochondrial deoxyribonucleic acid (mtDNA) copy number (mtDNA CN) measured in whole blood from participants of African and European origins in five cohorts (n = 6182, mean

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114263bbc14adc19536a3453c0ee3b6c
https://doi.org/10.1093/hmg/ddab240

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL

Autor: Esteban J. Parra, Craig L. Hanis, Lisa Sanchez-Johnsen, Kristin L. Young, Misa Graff, Yujie Wang, Adán Valladares, Lauren E. Petty, Yii-Der Ida Chen, Xiuqing Guo, Mark O. Goodarzi, Miguel Cruz, Kari E. North, Anny H. Xiang, Leslie J. Raffel, Matthew A. Allison, Tamar Sofer, Yann C. Klimentidis, Shelly Ann Love, Anne E. Justice, Stephanie M. Gogarten, Fernando Pires Hartwig, Thomas A. Buchanan, Jennifer E. Below, Jingyi Tan, Jie Yao, Jerome I. Rotter, Willa A. Hsueh, Eli Ipp, Walter Palmas, Kent D. Taylor, Heather M. Highland, Carmen R. Isasi

Publikováno v: Human Molecular Genetics

Author(s): Justice, Anne E; Young, Kristin; Gogarten, Stephanie M; Sofer, Tamar; Graff, Misa; Love, Shelly Ann M; Wang, Yujie; Klimentidis, Yann C; Cruz, Miguel; Guo, Xiuqing; Hartwig, Fernando; Petty, Lauren; Yao, Jie; Allison, Matthew A; Below, Jen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15cac64361a0fc5f1a4eb230f0daa7c
https://doi.org/10.1093/hmg/ddab166

Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction

Autor: Vilmundur Gudnason, Solomon K. Musani, Yi-Ping Fu, Albert V. Smith, Yii-Der Ida Chen, Annapurna Kuppa, Xiuqing Guo, Matthew A. Allison, Sharon L.R. Kardia, Donald W. Bowden, Gudny Eirksdottir, Jill M. Norris, Jian Yang, Bratati Kahali, Yanhua Chen, Thomas H. Mosley, Elizabeth K. Speliotes, Lenore J. Launer, James G. Terry, Brian D. Halligan, Jerome I. Rotter, Matthew J. Budoff, Kent D. Taylor, Kathleen A. Ryan, Breland F. Crudup, Adolfo Correa, Lawrence F. Bielak, Jeffrey R. O'Connell, Michael A. Province, Patricia A. Peyser, Nicholette D. Palmer, Christopher J. O'Donnell, Mary F. Feitosa, Lynne E. Wagenknecht, J. Jeffrey Carr, Xiaomeng Du

Publikováno v: Human molecular genetics, vol 30, iss 15
Hum Mol Genet

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1410659c19fddb97f8c0e22ad4dda1
https://doi.org/10.1093/hmg/ddab096