Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Assieh Saadatpour"'
Autor:
Guo-Cheng Yuan, Long Cai, Michael Elowitz, Tariq Enver, Guoping Fan, Guoji Guo, Rafael Irizarry, Peter Kharchenko, Junhyong Kim, Stuart Orkin, John Quackenbush, Assieh Saadatpour, Timm Schroeder, Ramesh Shivdasani, Itay Tirosh
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular information at the individual cell level. Development of single-cell technologies and computational methods has enabled systematic investigation of ce
Externí odkaz:
https://doaj.org/article/52a3f62434394e26b80ed3c3002e85e6
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1436-1445.e3 (2018)
Summary: Recent progress in single-cell technologies has enabled the identification of all major cell types in mouse. However, for most cell types, the regulatory mechanism underlying their identity remains poorly understood. By computational analysi
Externí odkaz:
https://doaj.org/article/a11365ecda2a46fa9214f5a4d216e497
Autor:
Tae-Hee Kim, Assieh Saadatpour, Guoji Guo, Madhurima Saxena, Alessia Cavazza, Niyati Desai, Unmesh Jadhav, Lan Jiang, Miguel N. Rivera, Stuart H. Orkin, Guo-Cheng Yuan, Ramesh A. Shivdasani
Publikováno v:
Cell Reports, Vol 16, Iss 8, Pp 2053-2060 (2016)
Lgr5+ intestinal stem cells (ISCs) drive epithelial self-renewal, and their immediate progeny—intestinal bipotential progenitors—produce absorptive and secretory lineages via lateral inhibition. To define features of early transit from the ISC co
Externí odkaz:
https://doaj.org/article/a4674e18cbf948c4ab793a6f860027fe
Autor:
Assieh Saadatpour, Rui-Sheng Wang, Aijun Liao, Xin Liu, Thomas P Loughran, István Albert, Réka Albert
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 11, p e1002267 (2011)
The blood cancer T cell large granular lymphocyte (T-LGL) leukemia is a chronic disease characterized by a clonal proliferation of cytotoxic T cells. As no curative therapy is yet known for this disease, identification of potential therapeutic target
Externí odkaz:
https://doaj.org/article/73dfc78eef484832819fefb52021181e
Autor:
Kai W. Wucherpfennig, Guo-Cheng Yuan, Benjamin Izar, Assieh Saadatpour, Archis Bagati, Adrienne Luoma, Johannes Melms, Sushil Kumar, Soumya Badrinath, Shengbao Suo, Adam N.R. Cartwright
Supplementary Table 1. Summary of proposed mechanisms of MDSC-mediated suppression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bc9c75ed7f4ab0dbdd06f9b35184a1
https://doi.org/10.1158/2326-6066.22543297.v1
https://doi.org/10.1158/2326-6066.22543297.v1
Autor:
Kai W. Wucherpfennig, Guo-Cheng Yuan, Benjamin Izar, Assieh Saadatpour, Archis Bagati, Adrienne Luoma, Johannes Melms, Sushil Kumar, Soumya Badrinath, Shengbao Suo, Adam N.R. Cartwright
Tumor-infiltrating myeloid-derived suppressor cells (MDSC) are associated with poor survival outcomes in many human cancers. MDSCs inhibit T cell–mediated tumor immunity in part because they strongly inhibit T-cell function. However, whether MDSCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c54f584b44e7bcab451f866c722f5d
https://doi.org/10.1158/2326-6066.c.6550204
https://doi.org/10.1158/2326-6066.c.6550204
Autor:
Kai W. Wucherpfennig, Guo-Cheng Yuan, Benjamin Izar, Assieh Saadatpour, Archis Bagati, Adrienne Luoma, Johannes Melms, Sushil Kumar, Soumya Badrinath, Shengbao Suo, Adam N.R. Cartwright
Supplementary Figures 1-8 with Legends included
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96346dd390062b69d63327f1d27d270
https://doi.org/10.1158/2326-6066.22543300
https://doi.org/10.1158/2326-6066.22543300
Autor:
Sherene Loi, Roberto Salgado, Peter Schmid, Javier Cortes, David W. Cescon, Eric P. Winer, Deborah L. Toppmeyer, Hope S. Rugo, Michelino De Laurentiis, Rita Nanda, Hiroji Iwata, Ahmad Awada, Antoinette R. Tan, Yuan Sun, Vassiliki Karantza, Anran Wang, Lingkang Huang, Assieh Saadatpour, Razvan Cristescu, Jennifer Yearley, Jared Lunceford, Petar Jelinic, Sylvia Adams
Publikováno v:
JCO Precision Oncology.
PURPOSE In the two-cohort phase II KEYNOTE-086 study (ClinicalTrials.gov identifier: NCT02447003 ), first-line and second-line or later pembrolizumab monotherapy demonstrated antitumor activity in metastatic triple-negative breast cancer (mTNBC; N =
Autor:
Petros Grivas, Blanca Homet Moreno, James Luke Godwin, Mohini Rajasagi, Junshui Ma, Andrey Loboda, Assieh Saadatpour, Jared Lunceford, Razvan Cristescu, Nicholas J. Vogelzang, Jacqueline Vuky, David I. Quinn, Howard Gurney, Winald Gerritsen, Stephane Culine, Toni K. Choueiri, Daniel Castellano, Arjun V. Balar, Dean F. Bajorin, Elizabeth R. Plimack, Thomas Powles, Peter H. O'Donnell, Cora N. Sternberg, Andrea Necchi, Lawrence Fong, Jae-Lyun Lee, Daniel P. Petrylak, Miguel A. Climent, Yves Fradet, Ronald de Wit, Joaquim Bellmunt
Purpose:In an exploratory analysis, we investigated the association between programmed death ligand 1 (PD-L1), tumor mutational burden (TMB), T-cell–inflamed gene expression profile (TcellinfGEP), and stromal signature with outcomes of pembrolizuma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c0b526adf25e6c0a35a819b7ea2c27
https://doi.org/10.1158/1078-0432.c.6532491
https://doi.org/10.1158/1078-0432.c.6532491
Autor:
Petros Grivas, Blanca Homet Moreno, James Luke Godwin, Mohini Rajasagi, Junshui Ma, Andrey Loboda, Assieh Saadatpour, Jared Lunceford, Razvan Cristescu, Nicholas J. Vogelzang, Jacqueline Vuky, David I. Quinn, Howard Gurney, Winald Gerritsen, Stephane Culine, Toni K. Choueiri, Daniel Castellano, Arjun V. Balar, Dean F. Bajorin, Elizabeth R. Plimack, Thomas Powles, Peter H. O'Donnell, Cora N. Sternberg, Andrea Necchi, Lawrence Fong, Jae-Lyun Lee, Daniel P. Petrylak, Miguel A. Climent, Yves Fradet, Ronald de Wit, Joaquim Bellmunt
Supplementary Data from Putative Biomarkers of Clinical Benefit With Pembrolizumab in Advanced Urothelial Cancer: Results from the KEYNOTE-045 and KEYNOTE-052 Landmark Trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9e78538f697754f5972aaf04722806
https://doi.org/10.1158/1078-0432.22487295.v1
https://doi.org/10.1158/1078-0432.22487295.v1