Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Assia Shisheva"'
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204532 (2018)
PIKfyve, an evolutionarily conserved kinase synthesizing PtdIns5P and PtdIns(3,5)P2, is crucial for mammalian cell proliferation and viability. Accordingly, PIKfyve inhibitors are now in clinical trials as anti-cancer drugs. Among those, apilimod is
Externí odkaz:
https://doaj.org/article/8ff7ec8dfdaa44b1b82f0c9ffb9cf59b
Publikováno v:
Diabetes. 71
Obesity is a major risk factor for Type 2 Diabetes (T2D) yet the majority of obese subjects never develop T2D and their metabolic tissues never lose insulin sensitivity. This suggests a key role of genetic predisposition to T2D development in obesity
Publikováno v:
Toxicology and Applied Pharmacology. 356:151-158
PIKfyve phosphoinositide kinase produces PtdIns(3,5)P2 and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell proliferation. The latter entails rigorous investigation since the cytotoxicity of PIKfyve i
Autor:
Sreenivasa R. Chinni, Assia Shisheva, Barani Govindarajan, Diego Sbrissa, Louie Semaan, Michael L. Cher, Nicholas J. Caruthers, Seema Sethi, Yanfeng Li, Paul M. Stemmer, Ulka N. Vaishampayan
Publikováno v:
Oncogene
Chemokine signaling regulates cell migration and tumor metastasis. CXCL12, a member of the chemokine family, and its receptor, CXCR4, a G protein coupled receptor (GPCR), are key mediators of prostate-cancer (PC) bone metastasis. In PC cells androgen
Publikováno v:
Experimental Cell Research. 349:310-319
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes numerous post-translational modifications, which impart new function and influence intracellular location. For example, atypical PKC ι/λ phosphorylates GAPDH that locates to vesicular tubul
Publikováno v:
Molecular neurobiology. 56(12)
Charcot-Marie-Tooth disease type-4J (CMT4J), an autosomal recessively inherited peripheral neuropathy characterized by neuronal degeneration, segmental demyelination, and limb muscle weakness, is caused by compound heterozygous mutations in the SAC3/
Autor:
Xuequn Chen, Lauren M. Compton, Ellen J. Tisdale, Ognian C. Ikonomov, Assia Shisheva, Diego Sbrissa, Rita Kumar
Publikováno v:
Journal of Biological Chemistry. 290:28515-28529
The 5-phosphoinositide phosphatase Sac3, in which loss-of-function mutations are linked to neurodegenerative disorders, forms a stable cytosolic complex with the scaffolding protein ArPIKfyve. The ArPIKfyve-Sac3 heterodimer interacts with the phospho
Publikováno v:
Toxicology and Applied Pharmacology. 383:114771
Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cy
Publikováno v:
BioEssays. 37:267-277
Recently, we have presented data supporting the notion that PIKfyve not only produces the majority of constitutive phosphatidylinositol 5-phosphate (PtdIns5P) in mammalian cells but that it does so through direct synthesis from PtdIns. Another group,
Autor:
Cristiana F. Pires, Mafalda Lopes da Silva, Laura Cabrita-Santos, Assia Shisheva, Miguel C. Seabra, Ognian C. Ikonomov, Elsa Seixas, Duarte C. Barral, José S. Ramalho, Carolina Thieleke-Matos
Publikováno v:
Traffic. 15:1066-1082
Malaria parasites go through an obligatory liver stage before they infect erythrocytes and cause disease symptoms. In the host hepatocytes, the parasite is enclosed by a parasitophorous vacuole membrane (PVM). Here, we dissected the interaction betwe