Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia.

Autor: Adamo A; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Chin P; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Keane P; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Assi SA; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Potluri S; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Kellaway SG; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Coleman D; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Ames L; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Ptasinska A; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Delwel HR; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Cockerill PN; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK., Bonifer C; Institute of Cancer and Genomic Sciences, University of Birmingham, B152TT, Birmingham, UK. c.bonifer@bham.ac.uk.

Publikováno v: Leukemia [Leukemia] 2023 Jan; Vol. 37 (1), pp. 102-112. Date of Electronic Publication: 2022 Nov 04.

Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis.

Autor: Potluri S; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Kellaway SG; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Blood Cancer and Stem Cells, Centre for Cancer Sciences, School of Medicine, University of Nottingham, Nottingham, UK., Coleman DJL; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Keane P; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; School of Biosciences, University of Birmingham, Birmingham, UK., Imperato MR; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Assi SA; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Cockerill PN; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Bonifer C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. c.bonifer@bham.ac.uk.

Publikováno v: Leukemia [Leukemia] 2024 Feb; Vol. 38 (2), pp. 403-407. Date of Electronic Publication: 2024 Jan 04.

Transcriptional reprogramming by mutated IRF4 in lymphoma.

Autor: Schleussner N; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Cauchy P; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.; University Medical Center Freiburg, 79106, Freiburg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Franke V; Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück-Center, Berlin, Germany., Giefing M; Institute of Human Genetics, Polish Academy of Sciences, Poznan, 60-479, Poland.; Institute of Human Genetics, Christian-Albrechts-University Kiel, 24105, Kiel, Germany., Fornes O; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada., Vankadari N; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3000, Australia., Assi SA; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Costanza M; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Weniger MA; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, 45122, Essen, Germany., Akalin A; Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück-Center, Berlin, Germany., Anagnostopoulos I; Institute of Pathology, Universität Würzburg and Comprehensive Cancer Centre Mainfranken (CCCMF), Würzburg, Germany., Bukur T; TRON gGmbH - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany., Casarotto MG; Research School of Biology, The Australian National University, Canberra, ACT, Australia., Damm F; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany., Daumke O; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Structural Biology, 13125, Berlin, Germany., Edginton-White B; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Gebhardt JCM; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany., Grau M; Department of Physics, University of Marburg, 35052, Marburg, Germany.; Medical Department A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Grunwald S; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Structural Biology, 13125, Berlin, Germany., Hansmann ML; Frankfurt Institute of Advanced Studies, Frankfurt am Main, Germany.; Institute for Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Hartmann S; Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt, Frankfurt am Main, Germany., Huber L; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany., Kärgel E; Signal Transduction in Tumor Cells, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany., Lusatis S; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Noerenberg D; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany., Obier N; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Pannicke U; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany., Fischer A; Institute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany., Reisser A; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany., Rosenwald A; Institute of Pathology, Universität Würzburg and Comprehensive Cancer Centre Mainfranken (CCCMF), Würzburg, Germany., Schwarz K; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Württemberg-Hessen, Ulm, Germany., Sundararaj S; Research School of Biology, The Australian National University, Canberra, ACT, Australia., Weilemann A; Medical Department A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Winkler W; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Xu W; Medical Department A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Lenz G; Medical Department A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Rajewsky K; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Immune Regulation and Cancer, 13125, Berlin, Germany., Wasserman WW; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada., Cockerill PN; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Scheidereit C; Signal Transduction in Tumor Cells, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany., Siebert R; Institute of Human Genetics, Christian-Albrechts-University Kiel, 24105, Kiel, Germany.; Institute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany., Küppers R; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, 45122, Essen, Germany., Grosschedl R; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany., Janz M; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Bonifer C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Mathas S; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany. stephan.mathas@charite.de.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany. stephan.mathas@charite.de.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany. stephan.mathas@charite.de.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. stephan.mathas@charite.de.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 07; Vol. 14 (1), pp. 6947. Date of Electronic Publication: 2023 Nov 07.

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia.

Autor: Tirtakusuma R; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Szoltysek K; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Maria Sklodowska-Curie Institute, Oncology Center, Gliwice Branch, Gliwice, Poland., Milne P; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Grinev VV; Department of Genetics, the Faculty of Biology, Belarusian State University, Minsk, Republic of Belarus., Ptasinska A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Chin PS; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Meyer C; Institute of Pharmaceutical Biology/DCAL, Goethe-University, Frankfurt/Main, Germany., Nakjang S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Hehir-Kwa JY; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Williamson D; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Cauchy P; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Keane P; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Assi SA; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Ashtiani M; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Kellaway SG; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Imperato MR; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Vogiatzi F; ALL-BFM Study Group, Pediatric Hematology/Oncology, Christian Albrechts University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Germany., Schweighart EK; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Lin S; Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Wunderlich M; Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Stutterheim J; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Komkov A; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia., Zerkalenkova E; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia., Evans P; Haematological Malignancy Diagnostic Service, St James's University Hospital, Leeds, United Kingdom., McNeill H; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Elder A; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Martinez-Soria N; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Fordham SE; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Shi Y; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Russell LJ; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Pal D; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Smith A; Epidemiology and Cancer Statistics Group, University of York, York, United Kingdom., Kingsbury Z; Illumina Cambridge Ltd., Great Abington, United Kingdom., Becq J; Illumina Cambridge Ltd., Great Abington, United Kingdom., Eckert C; Department of Pediatric Oncology/Hematology, Charité Universitätsmedizin Berlin, Berlin, Germany., Haas OA; St Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Carey P; Department of Paediatric Haematology and Oncology, The Great North Children's Hospital, Newcastle upon Tyne, United Kingdom., Bailey S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Department of Paediatric Haematology and Oncology, The Great North Children's Hospital, Newcastle upon Tyne, United Kingdom., Skinner R; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Department of Paediatric Haematology and Oncology, The Great North Children's Hospital, Newcastle upon Tyne, United Kingdom., Miakova N; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia., Collin M; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Bigley V; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Haniffa M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.; Department of Dermatology and Newcastle National Institute of Health Research (NIHR), Newcastle Biomedical Research Centre, Newcastle Hospitals National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, United Kingdom., Marschalek R; Institute of Pharmaceutical Biology/DCAL, Goethe-University, Frankfurt/Main, Germany., Harrison CJ; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Cargo CA; Haematological Malignancy Diagnostic Service, St James's University Hospital, Leeds, United Kingdom., Schewe D; Department of Pediatrics, Otto von Guericke University Magdeburg, Magdeburg, Germany., Olshanskaya Y; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia., Thirman MJ; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL., Cockerill PN; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Mulloy JC; Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Blair HJ; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Vormoor J; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Allan JM; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Bonifer C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Heidenreich O; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Bomken S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Department of Paediatric Haematology and Oncology, The Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.

Publikováno v: Blood [Blood] 2022 Oct 27; Vol. 140 (17), pp. 1875-1890.

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.

Autor: Schnoeder TM; Innere Medizin C, Hämatologie, Onkologie, Stammzelltransplantation und Palliativmedizin, Universitätsmedizin Greifswald, Greifswald, Germany., Schwarzer A; Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, and.; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Jayavelu AK; Max-Planck-Institute of Biochemistry, Munich, Germany., Hsu CJ; Innere Medizin C, Hämatologie, Onkologie, Stammzelltransplantation und Palliativmedizin, Universitätsmedizin Greifswald, Greifswald, Germany., Kirkpatrick J; Leibniz Institute on Aging, Fritz-Lipmann Institute (FLI), Jena, Germany., Döhner K; Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany., Perner F; Innere Medizin C, Hämatologie, Onkologie, Stammzelltransplantation und Palliativmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.; Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard University, Boston, MA., Eifert T; Innere Medizin C, Hämatologie, Onkologie, Stammzelltransplantation und Palliativmedizin, Universitätsmedizin Greifswald, Greifswald, Germany., Huber N; Innere Medizin C, Hämatologie, Onkologie, Stammzelltransplantation und Palliativmedizin, Universitätsmedizin Greifswald, Greifswald, Germany., Arreba-Tutusaus P; Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tübingen, Tübingen, Germany., Dolnik A; Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany., Assi SA; Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Nafria M; Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Jiang L; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Dai YT; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Chen Z; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Chen SJ; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Kellaway SG; Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Ptasinska A; Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Ng ES; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia., Stanley EG; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia.; Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne Parkville, VIC, Australia., Elefanty AG; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia., Buschbeck M; Josep Carreras Leukemia Research Institute, Badalona, Spain., Bierhoff H; Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University, Jena, Germany., Brodt S; University Hospital Jena, Orthopaedic Department at Campus Eisenberg, Eisenberg, Germany., Matziolis G; University Hospital Jena, Orthopaedic Department at Campus Eisenberg, Eisenberg, Germany., Fischer KD; Institute for Cell Biology and Biochemistry, Otto-von-Guericke University, Magdeburg, Germany., Hochhaus A; Innere Medizin 2, Hämatologie und Onkologie, Universitätsklinikum Jena, Germany., Chen CW; Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA., Heidenreich O; Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, United Kingdom.; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands; and., Mann M; Max-Planck-Institute of Biochemistry, Munich, Germany., Lane SW; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Bullinger L; Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany., Ori A; Leibniz Institute on Aging, Fritz-Lipmann Institute (FLI), Jena, Germany., von Eyss B; Leibniz Institute on Aging, Fritz-Lipmann Institute (FLI), Jena, Germany., Bonifer C; Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Heidel FH; Innere Medizin C, Hämatologie, Onkologie, Stammzelltransplantation und Palliativmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.; Leibniz Institute on Aging, Fritz-Lipmann Institute (FLI), Jena, Germany.; Innere Medizin 2, Hämatologie und Onkologie, Universitätsklinikum Jena, Germany.

Publikováno v: Blood [Blood] 2022 Feb 17; Vol. 139 (7), pp. 1080-1097.