Výsledky vyhledávání - "Asser Bassyouni"

Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters

Autor: Stephen Jenkinson, Dingzhou Li, David J. MacEwan, Peter Kilfoil, Eric D. Watt, Derek J. Leishman, Parveen Sharma, Tiffany Lee, Asser Bassyouni, Shuyun Lily Feng

Publikováno v: European Journal of Pharmacology

Human induced pluripotent stem cell derived cardiomyocytes (hIPSC-CM's) play an increasingly important role in the safety profiling of candidate drugs. For such models to have utility a clear understanding of clinical translation is required. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354b5671ca62b0aeeb7522f5069bc852
https://pubmed.ncbi.nlm.nih.gov/34678241

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Cardiac sodium channel antagonism – Translation of preclinical in vitro assays to clinical QRS prolongation

Autor: Donglin Guo, Bernard Fermini, David S. Ramirez, Stephen Jenkinson, Asser Bassyouni, Jason Cordes, Todd Wisialowski, Sunny Z. Sun, David M. Potter, Jill Steidl-Nichols

Publikováno v: Journal of Pharmacological and Toxicological Methods. 89:9-18

Introduction Cardiac sodium channel antagonists have historically been used to treat cardiac arrhythmias by preventing the reentry of the electrical impulse that could occur following myocardial damage. However, clinical studies have highlighted a si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af8646dabdbc80e028ae938b088d883
https://doi.org/10.1016/j.vascn.2017.10.002

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L-type calcium channel antagonism – Translation from in vitro to in vivo

Autor: Asser Bassyouni, Sunny Z. Sun, Michelle Hemkens, Bernard Fermini, Todd Wisialowski, David S. Ramirez, Stephen Jenkinson

Publikováno v: Journal of Pharmacological and Toxicological Methods. 84:86-92

Introduction Although therapeutically beneficial in the treatment of certain diseases, L-type calcium channel antagonism can result in unwanted off-target pharmacology leading to adverse drug reactions and to the termination of the development of oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc60b802e3079ed6b76810c933766e1d
https://doi.org/10.1016/j.vascn.2016.11.002

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Ligand biological activity predicted by cleaning positive and negative chemical correlations

Autor: Alpha A. Lee, Xinjun Hou, Christopher Ryan Butler, Stephen Jenkinson, David Price, Asser Bassyouni, Qingyi Yang

Predicting ligand biological activity is a key challenge in drug discovery. Ligand-based statistical approaches are often hampered by noise due to undersampling: The number of molecules known to be active or inactive is vastly less than the number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe2f6f47f54c6ab25492ca66566beca

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Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints

Autor: Paul Butler, Susan M.G. Goody, Annie Otto-Bruc, Jamie K. DaSilva, Rhys M. Jones, Andy N. Mead, Asser Bassyouni, Stephen Jenkinson, Stephanie Duquennoy

Publikováno v: Journal of Pharmacological and Toxicological Methods. 104:106899

Introduction Building an understanding of in vivo efficacy based on the evaluation of in vitro affinity or potency is critical in expediting early decision making in drug discovery and can significantly reduce the need for animal studies. The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430ed02441c6880c6896f2d5be537453
https://doi.org/10.1016/j.vascn.2020.106899

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