Zobrazeno 1 - 10
of 1 320
pro vyhledávání: '"Assay development"'
Autor:
Jay A. Fishman, Nicolas J. Mueller
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 7, Pp 1311-1318 (2024)
Xenotransplantation, transplantation into humans of vascularized organs or viable cells from nonhuman species, is a potential solution to shortages of transplantable human organs. Among challenges to application of clinical xenotransplantation are un
Externí odkaz:
https://doaj.org/article/c5b48b94db11409f981be107473b8ac8
Autor:
Michel Siegel, Aman Padamsey, Anna-Lena Bolender, Patrick Hargreaves, Johannes Fraidling, Axel Ducret, Katharina Hartman, Cary M. Looney, Cristina Bertinetti-Lapatki, Olivier Rohr, Timothy P. Hickling, Thomas E. Kraft, Céline Marban-Doran
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionImmunogenicity refers to the ability of a substance, such as a therapeutic drug, to elicit an immune response. While beneficial in vaccine development, undesirable immunogenicity can compromise the safety and efficacy of therapeutic prote
Externí odkaz:
https://doaj.org/article/7d40f92e19414c188759d42872e0dd4b
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/17dac23ea513494fa8cfbd02011bada7
Publikováno v:
SLAS Technology, Vol 29, Iss 1, Pp 100115- (2024)
This study aimed to develop a streamlined method for evaluating the dilution ratio of drug dose–response plates created by automated liquid handlers in the early stages of drug discovery. The quantitative techniques commonly used for this purpose h
Externí odkaz:
https://doaj.org/article/ca8bd8748feb4d679cd31686a0825e86
Autor:
Evan A. Elko, Heather L. Mead, Georgia A. Nelson, John A. Zaia, Jason T. Ladner, John A. Altin
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages of the Omicron variant rapidly became dominant in early 2022 and frequently cause human infections despite vaccination or prior infection with other variants. In addition t
Externí odkaz:
https://doaj.org/article/85f6027edcdb48be85135a982d242757
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 188-192 (2023)
Lymphocyte activation gene 3 (LAG-3) is a negative immune checkpoint and a key regulator of immune homeostasis with multiple biological activities related to T-cell functions. Fibrinogen-like protein 1 (FGL1) is a major LAG-3 functional ligand that i
Externí odkaz:
https://doaj.org/article/77fe2d52a1ea43f9b5af6ce3a1077694
Autor:
Maarten De Brauwer, Laurence J. Clarke, Anthony Chariton, Madalyn K. Cooper, Mark de Bruyn, Elise Furlan, Anna J. MacDonald, Meaghan L. Rourke, Craig D. H. Sherman, Leonie Suter, Cecilia Villacorta‐Rath, Anastasija Zaiko, Alejandro Trujillo‐González
Publikováno v:
Environmental DNA, Vol 5, Iss 3, Pp 417-423 (2023)
Abstract Environmental DNA (eDNA)‐based methods are increasingly used by government agencies to detect pests and threatened species, and for broader biodiversity monitoring. Given rapid technological advances and a growing number of commercial serv
Externí odkaz:
https://doaj.org/article/18e56ff551954af6adc0f22ce4e97518
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The genus Bartonella includes a group of species that are associated with a wide range of mammalian species, including human. It is challenging to detect all Bartonella species using a single molecular target due to its high genetic diversity. To sol
Externí odkaz:
https://doaj.org/article/a77cf8669c6f4b12b595d7be564f2995
Autor:
Jacob E. Larson, P. Brian Hardy, Noah K. Schomburg, Xiaodong Wang, Dmitri Kireev, Kent L. Rossman, Kenneth H. Pearce
Publikováno v:
SLAS Discovery, Vol 28, Iss 1, Pp 39-47 (2023)
Mutations in the small GTPase protein KRAS are one of the leading drivers of cancers including lung, pancreatic, and colorectal, as well as a group of developmental disorders termed “Rasopathies”. Recent breakthroughs in the development of mutant
Externí odkaz:
https://doaj.org/article/d51a173c0d3d402c8c67f70bb132faf6
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/c5597a9199f04713a8263a810399611b