Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Assam El‐Osta"'
Autor:
Maria Cristina Vinci, Sarah Costantino, Giulia Damiano, Erica Rurali, Raffaella Rinaldi, Vera Vigorelli, Annalisa Sforza, Ermes Carulli, Sergio Pirola, Giorgio Mastroiacovo, Angela Raucci, Assam El-Osta, Francesco Paneni, Giulio Pompilio
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-15 (2024)
Abstract Background Diabetes-induced trained immunity contributes to the development of atherosclerosis and its complications. This study aimed to investigate in humans whether epigenetic signals involved in immune cell activation and inflammation ar
Externí odkaz:
https://doaj.org/article/d3b11f884e50459ca0308cca65a3f79e
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/96fb49194aaa4e0f911fa258577dc84e
Autor:
Keith Al-Hasani, Safiya Naina Marikar, Harikrishnan Kaipananickal, Scott Maxwell, Jun Okabe, Ishant Khurana, Thomas Karagiannis, Julia J. Liang, Lina Mariana, Thomas Loudovaris, Thomas Kay, Assam El-Osta
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and release insulin. In type 1 diabetes (T1D), T-cells of the immune system selectively destroy the insulin-producing β-cells. Destruction of these cell
Externí odkaz:
https://doaj.org/article/a14c0d5910f4469ba3b5e5607fe3fe80
Autor:
Tom C. Karagiannis, Katherine Ververis, Julia J. Liang, Eleni Pitsillou, Evan A. Kagarakis, Debbie T. Z. Yi, Vivian Xu, Andrew Hung, Assam El-Osta
Publikováno v:
Molecules, Vol 29, Iss 15, p 3502 (2024)
In a landmark study, oleocanthal (OLC), a major phenolic in extra virgin olive oil (EVOO), was found to possess anti-inflammatory activity similar to ibuprofen, involving inhibition of cyclooxygenase (COX) enzymes. EVOO is a rich source of bioactive
Externí odkaz:
https://doaj.org/article/29ec5c7a362745bcae6755908e6074a7
Autor:
Tom C. Karagiannis, Katherine Ververis, Julia J. Liang, Eleni Pitsillou, Siyao Liu, Sarah M. Bresnehan, Vivian Xu, Stevano J. Wijoyo, Xiaofei Duan, Ken Ng, Andrew Hung, Erik Goebel, Assam El-Osta
Publikováno v:
Molecules, Vol 29, Iss 11, p 2446 (2024)
The Mediterranean diet well known for its beneficial health effects, including mood enhancement, is characterised by the relatively high consumption of extra virgin olive oil (EVOO), which is rich in bioactive phenolic compounds. Over 200 phenolic co
Externí odkaz:
https://doaj.org/article/e6fa27c2e71d42b0a3b170c21eb59163
Autor:
Safiya Naina Marikar, Keith Al-Hasani, Ishant Khurana, Harikrishnan Kaipananickal, Jun Okabe, Scott Maxwell, Assam El-Osta
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Therapeutic replacement of pancreatic endocrine β-cells is key to improving hyperglycaemia caused by insulin-dependent diabetes . Whilst the pool of ductal progenitors, which give rise to the endocrine cells, are active during de
Externí odkaz:
https://doaj.org/article/f768a6415bfc4ac8bcef572e3bf4fbf6
Autor:
Shira Perez, Anat Lavi-Itzkovitz, Moriah Gidoni, Tom Domovitz, Roba Dabour, Ishant Khurana, Ateret Davidovich, Ana Tobar, Alejandro Livoff, Evgeny Solomonov, Yaakov Maman, Assam El-Osta, Yishan Tsai, Ming-Lung Yu, Salomon M. Stemmer, Izhak Haviv, Gur Yaari, Meital Gal-Tanamy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 1, Pp 63-81 (2023)
Background & Aims: Hepatocellular carcinoma (HCC) is a model of a diverse spectrum of cancers because it is induced by well-known etiologies, mainly hepatitis C virus (HCV) and hepatitis B virus. Here, we aimed to identify HCV-specific mutational sig
Externí odkaz:
https://doaj.org/article/2504d44cdec5437d864285de9108428c
Autor:
Eleni Pitsillou, Alexander N. O. Logothetis, Julia J. Liang, Assam El-Osta, Andrew Hung, Asmaa S. AbuMaziad, Tom C. Karagiannis
Publikováno v:
Molecules, Vol 28, Iss 24, p 7946 (2023)
Genetic abnormalities have been associated with primary aldosteronism, a major cause of secondary hypertension. This includes mutations in the KCNJ5 gene, which encodes G protein-gated inwardly rectifying K+ channel 4 (GIRK4). For example, the substi
Externí odkaz:
https://doaj.org/article/1dffc6bc833241229cccb4868d521a98
Autor:
Keith Al-Hasani, Ishant Khurana, Lina Mariana, Thomas Loudovaris, Scott Maxwell, K. N. Harikrishnan, Jun Okabe, Mark E. Cooper, Assam El-Osta
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys insulin-producing β-cells in the pancreas. An unmet need in diabetes management, current therapy is focussed on transplantation. While the reprogramming of progenitor
Externí odkaz:
https://doaj.org/article/f66d28f2b6e44e479456526aaa0db345
Autor:
Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sørine Birkelund, Anna Syreeni, Carol Forsblom, Jun Okabe, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Anne Jørgensen, Keith Al-Hasani, Merlin C. Thomas, Guozhi Jiang, Andrea O.Y. Luk, Heung Man Lee, Yu Huang, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Thep Himathongkam, Christopher Fogarty, Rachel Njeim, Assaad Eid, Tine Willum Hansen, Nete Tofte, Evy C. Ottesen, Ronald C.W. Ma, Juliana C.N. Chan, Mark E. Cooper, Peter Rossing, Per-Henrik Groop, Assam El-Osta
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the prevailing genomic view to dist
Externí odkaz:
https://doaj.org/article/64117e1fe4b8440bb9cf852ef9a65858