Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Assaf Kacen"'
Autor:
Aaron Javitt, Merav D. Shmueli, Matthias P. Kramer, Aleksandra A. Kolodziejczyk, Ivan J. Cohen, Lihi Radomir, Daoud Sheban, Iris Kamer, Kevin Litchfield, Elizabeta Bab-Dinitz, Oranit Zadok, Vanessa Neiens, Adi Ulman, Hila Wolf-Levy, Avital Eisenberg-Lerner, Assaf Kacen, Michal Alon, Ana Toste Rêgo, Elvira Stacher-Priehse, Michael Lindner, Ina Koch, Jair Bar, Charles Swanton, Yardena Samuels, Yishai Levin, Paula C. A. da Fonseca, Eran Elinav, Nir Friedman, Silke Meiners, Yifat Merbl
Publikováno v:
Nature Cancer. 4:629-647
Autor:
Assaf Kacen, Aaron Javitt, Matthias P. Kramer, David Morgenstern, Tomer Tsaban, Merav D. Shmueli, Guo Ci Teo, Felipe da Veiga Leprevost, Eilon Barnea, Fengchao Yu, Arie Admon, Lea Eisenbach, Yardena Samuels, Ora Schueler-Furman, Yishai Levin, Alexey I. Nesvizhskii, Yifat Merbl
Publikováno v:
Nature Biotechnology. 41:239-251
Post-translational modification (PTM) of antigens provides an additional source of specificities targeted by immune responses to tumors or pathogens, but identifying antigen PTMs and assessing their role in shaping the immunopeptidome is challenging.
Autor:
Brianna Duncan-Lowey, Nitzan Tal, Alex G. Johnson, Shaun Rawson, Megan L. Mayer, Shany Doron, Adi Millman, Sarah Melamed, Taya Fedorenko, Assaf Kacen, Gil Amitai, Rotem Sorek, Philip J. Kranzusch
SummaryRADAR is a two-protein bacterial defense system which was reported to defend against phage by ‘editing’ messenger RNA. Here we determine cryo-EM structures of the RADAR defense complex, revealing RdrA as a heptameric, two-layered AAA+ ATPa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::517163ced1057ca0d47f415f233c25c2
https://doi.org/10.1101/2022.08.17.504323
https://doi.org/10.1101/2022.08.17.504323
Autor:
Adi Millman, Sarah Melamed, Azita Leavitt, Shany Doron, Aude Bernheim, Jens Hör, Jeremy Garb, Nathalie Bechon, Alexander Brandis, Anna Lopatina, Gal Ofir, Dina Hochhauser, Avigail Stokar-Avihail, Nitzan Tal, Saar Sharir, Maya Voichek, Zohar Erez, Jose Lorenzo M. Ferrer, Daniel Dar, Assaf Kacen, Gil Amitai, Rotem Sorek
Publikováno v:
Cell hostmicrobe. 30(11)
Bacterial anti-phage systems are frequently clustered in microbial genomes, forming defense islands. This property enabled the recent discovery of multiple defense systems based on their genomic co-localization with known systems, but the full arsena
Autor:
Adi Millman, Sarah Melamed, Azita Leavitt, Shany Doron, Aude Bernheim, Jens Hör, Anna Lopatina, Gal Ofir, Dina Hochhauser, Avigail Stokar-Avihail, Nitzan Tal, Saar Sharir, Maya Voichek, Zohar Erez, Jose Lorenzo M. Ferrer, Daniel Dar, Assaf Kacen, Gil Amitai, Rotem Sorek
Bacterial anti-phage defense systems are frequently clustered in microbial genomes, forming defense islands. This genomic property enabled the recent discovery of multiple defense systems based on their genomic co-localization with known systems, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d10facbfbe854430d95f6a2108fe4d17
https://doi.org/10.1101/2022.05.11.491447
https://doi.org/10.1101/2022.05.11.491447
Autor:
Brianna Duncan-Lowey, Nitzan Tal, Alex G. Johnson, Shaun Rawson, Megan L. Mayer, Shany Doron, Adi Millman, Sarah Melamed, Taya Fedorenko, Assaf Kacen, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek, Philip J. Kranzusch
Publikováno v:
Cell. 186:987-998.e15
Autor:
Charles Swanton, Assaf Kacen, Aleksandra A. Kolodziejczyk, Matthias P. Kramer, Ina Koch, Michael Lindner, Stacher-Priehse E, Cohen Ij, Silke Meiners, Yifat Merbl, Aaron Javitt, Hila Wolf-Levy, Nir Friedman, Michal Alon, Yardena Samuels, Avital Eisenberg-Lerner, Shmueli, Radomir L, Elizabeta Bab-Dinitz, Oranit Zadok, Neiens, Ana Toste Rêgo, Yishai Levin, Adi Ulman, Iris Kamer, Eran Elinav, Jair Bar, da Fonseca Pca, Kevin Litchfield
SummaryProtein degradation by proteasomes is important for the immune response against tumors. Antigens generated by the proteasome promote immune cell infiltration into tumors and improve tumors’ responses to immunotherapy. For example, immunoprot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d786dd3d01be39253a760d3002979d
https://doi.org/10.1101/2021.10.24.464690
https://doi.org/10.1101/2021.10.24.464690
Autor:
Yifat Merbl, Alexey I. Nesvizhskii, Yishai Levin, Gal Cafri, Arie Admon, Ora Schueler-Furman, Matthias P. Kramer, Aaron Javitt, Lea Eisenbach, Tomer Tsaban, Guo Ci Teo, Assaf Kacen, Eilon Barnea, Adam Solomon, Fengchao Yu, Felipe da Veiga Leprevost, David Morgenstern
Antigen processing and presentation are critical for modulating tumor-host interactions. While post-translational modifications (PTMs) can alter the binding and recognition of antigens, their identification remains challenging. Here we uncover the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::846e9e7b11e36d1a14f3e42b747210ec
https://doi.org/10.1101/2021.04.10.438991
https://doi.org/10.1101/2021.04.10.438991
Autor:
Daoud Sheban, Tom Shani, Roey Maor, Alejandro Aguilera-Castrejon, Nofar Mor, Bernardo Oldak, Merav D. Shmueli, Avital Eisenberg-Lerner, Jonathan Bayerl, Jakob Hebert, Sergey Viukov, Guoyun Chen, Assaf Kacen, Vladislav Krupalnik, Valeriya Chugaeva, Shadi Tarazi, Alejandra Rodríguez-delaRosa, Mirie Zerbib, Adi Ulman, Solaiman Masarwi, Meital Kupervaser, Yishai Levin, Efrat Shema, Yael David, Noa Novershtern, Jacob H. Hanna, Yifat Merbl
Publikováno v:
Molecular Cell
The fidelity of the early embryonic program is underlined by tight regulation of the chromatin. Yet, how the chromatin is organized to prohibit the reversal of the developmental program remains unclear. Specifically, the totipotency-to-pluripotency t
Autor:
Daniel, Cohen, Sarah, Melamed, Adi, Millman, Gabriela, Shulman, Yaara, Oppenheimer-Shaanan, Assaf, Kacen, Shany, Doron, Gil, Amitai, Rotem, Sorek
Publikováno v:
Nature. 574(7780)
The cyclic GMP-AMP synthase (cGAS)-STING pathway is a central component of the cell-autonomous innate immune system in animals