Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

Autor: Roei D. Mazor, Nachum Nathan, Amit Gilboa, Liat Stoler-Barak, Lihee Moss, Inna Solomonov, Assaf Hanuna, Yalin Divinsky, Merav D. Shmueli, Hadas Hezroni, Irina Zaretsky, Michael Mor, Ofra Golani, Gad Sabah, Ariella Jakobson-Setton, Natalia Yanichkin, Meora Feinmesser, Daliah Tsoref, Lina Salman, Effi Yeoshoua, Eyal Peretz, Inna Erlich, Netta Mendelson Cohen, Jonathan M. Gershoni, Natalia Freund, Yifat Merbl, Gur Yaari, Ram Eitan, Irit Sagi, Ziv Shulman

Publikováno v: Cell

The tumor microenvironment hosts antibody-secreting cells (ASCs) associated with a favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic and therapeutic potential; yet, it remains unclear how antibodies gain autor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db70ec87b077ad74797e8d73a304e99

Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill.

Autor: Mohan, Vishnu¹ (AUTHOR) vishnu.mohan@weizmann.ac.il, Gaffney, Jean P.¹ (AUTHOR) jean.gaffney@baruch.cuny.edu, Solomonov, Inna¹ (AUTHOR) inna.solomonov@weizmann.ac.il, Levin, Maxim¹ (AUTHOR) maxim298@gmail.com, Klepfish, Mordehay¹ (AUTHOR) moty.kl@gmail.com, Akbareian, Sophia² (AUTHOR) sophieaelias@outlook.com, Grünwald, Barbara³ (AUTHOR) barbara.gruenwald@googlemail.com, Dym, Orly⁴ (AUTHOR) Orly.Dym@weizmann.ac.il, Eisenstein, Miriam⁵ (AUTHOR) miriam.eisenstein@weizmann.ac.il, Yu, Kenneth H.⁶ (AUTHOR) yuk1@mskcc.org, Kelsen, David P.⁶ (AUTHOR) kelsend@mskcc.org, Krüger, Achim³ (AUTHOR) achim.krueger@tum.de, Edwards, Dylan R.² (AUTHOR) dylan.edwards@uea.ac.uk, Sagi, Irit¹ (AUTHOR) irit.sagi@weizmann.ac.il, Mohammad, Ramzi M. (AUTHOR)

Publikováno v: Cancers. Apr2021, Vol. 13 Issue 7, p1679-1679. 1p.