Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Assaf Ganoth"'
Publikováno v:
Virus Research, Vol 342, Iss , Pp 199330- (2024)
The Middle East respiratory syndrome (MERS) is a severe respiratory disease with high fatality rates, caused by the Middle East respiratory syndrome coronavirus (MERS-CoV). The virus initiates infection by binding to the CD26 receptor (also known as
Externí odkaz:
https://doaj.org/article/d1a822487ed846c2a90b1b7757a79feb
Autor:
Yuval Bin Kanner, Qiu-Xu Teng, Assaf Ganoth, Dan Peer, Jing-Quan Wang, Zhe-Sheng Chen, Yossi Tsfadia
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Cancer is one of the leading causes of death worldwide, and the development of resistance to chemotherapy drugs is a major challenge in treating malignancies. In recent years, researchers have focused on understanding the mechanisms of multidrug resi
Externí odkaz:
https://doaj.org/article/40ab2f3d41d3461eaff5df8f603a74e4
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Dynamic conformational changes play a major role in the function of proteins, including the ATP-Binding Cassette (ABC) transporters. Multidrug Resistance Protein 1 (MRP1) is an ABC exporter that protects cells from toxic molecules. Overexpre
Externí odkaz:
https://doaj.org/article/9f35ae1891a940d4b2412cba4c56df47
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1007021 (2019)
[This corrects the article DOI: 10.1371/journal.pcbi.1006503.].
Externí odkaz:
https://doaj.org/article/a821d2357023473fab18dc410cd07b67
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 11, p e1006503 (2018)
Multiscale modeling provides a very powerful means of studying complex biological systems. An important component of this strategy involves coarse-grained (CG) simplifications of regions of the system, which allow effective exploration of complex sys
Externí odkaz:
https://doaj.org/article/5f1fe163e6e04cba8863a950558fc2d1
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Dynamic conformational changes play a major role in the function of proteins, including the ATP-Binding Cassette (ABC) transporters. Multidrug Resistance Protein 1 (MRP1) is an ABC exporter that protects tissues from toxic molecules. Overexpression o
Autor:
Shani Blanga-Kanfi, Assaf Ganoth, Ekaterina Lazdon, Limor Landsman, Dan Frenkel, Yossi Tsfadia, Guy Goldsmith, Lina Sakhneny, Hilit Levy-Barazany, Yuval Nash, Nofit Borenstein-Auerbach, Adi Kopelevich, Tali Benromano, Raphael Alhadeff, Katia Pozyuchenko
Publikováno v:
The FASEB Journal. 35
Inhibition of insulin-degrading enzyme (IDE) is a possible target for treating diabetes. However, it has not yet evolved into a medical intervention, mainly because most developed inhibitors target the zinc in IDE's catalytic site, potentially causin
Autor:
Or David Shahar, Ronen Gabizon, Oren Feine, Raphael Alhadeff, Assaf Ganoth, Liron Argaman, Elee Shimshoni, Assaf Friedler, Michal Goldberg
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78472 (2013)
Occurrence of DNA damage in a cell activates the DNA damage response, a survival mechanism that ensures genomics stability. Two key members of the DNA damage response are the tumor suppressor p53, which is the most frequently mutated gene in cancers,
Externí odkaz:
https://doaj.org/article/29113fee50ce49b59f507b6319c3c973
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26115 (2011)
Yersinia pestis, the bacterium that historically accounts for the Black Death epidemics, has nowadays gained new attention as a possible biological warfare agent. In this study, its Na⁺/H⁺ antiporter is investigated for the first time, by a combi
Externí odkaz:
https://doaj.org/article/9377b0edc1904d80b066ec144b7d1476
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25182 (2011)
The ability to discriminate between highly similar substrates is one of the remarkable properties of enzymes. For example, transporters and channels that selectively distinguish between various solutes enable living organisms to maintain and control
Externí odkaz:
https://doaj.org/article/a72e552f850c41a6afd34dccd3bed86e